Showing entry for Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013396
Protein NameEctonucleotide pyrophosphatase/phosphodiesterase family member 2
Uniport IdQ13822
GeneENPP2
Gene Id5168
DomainEndonuclease_NS; Phosphodiest; Somatomedin_B
Pfam PF01223   PF01663   PF01033  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00565 Ether lipid metabolism
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0048870 cell motility
Biological Process GO:0006935 chemotaxis
Biological Process GO:0006955 immune response
Biological Process GO:0034638 phosphatidylcholine catabolic process
Biological Process GO:0009395 phospholipid catabolic process
Biological Process GO:0010634 positive regulation of epithelial cell migration
Biological Process GO:2000394 positive regulation of lamellipodium morphogenesis
Biological Process GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
Biological Process GO:0045765 regulation of angiogenesis
Biological Process GO:0030334 regulation of cell migration
Biological Process GO:0030149 sphingolipid catabolic process
molecular function GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity
molecular function GO:0005509 calcium ion binding
molecular function GO:0016787 hydrolase activity
molecular function GO:0004622 lysophospholipase activity
molecular function GO:0003676 nucleic acid binding
molecular function GO:0004551 nucleotide diphosphatase activity
molecular function GO:0004528 phosphodiesterase I activity
molecular function GO:0030247 polysaccharide binding
molecular function GO:0005044 scavenger receptor activity
molecular function GO:0008134 transcription factor binding
molecular function GO:0008270 zinc ion binding
cellular component GO:0005615 extracellular space
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors
R-HSA-196854 Metabolism of vitamins and cofactors
R-HSA-199220 Vitamin B5 (pantothenate) metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004135 BXGD000257 Ataxia Telangiectasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0005411 BXGD000313 Biliary Atresia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0005612 BXGD000317 Birth Weight Pathological Conditions, Signs and Symptoms
C0005758 BXGD000335 Bulla Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0005779 BXGD000336 Blood Coagulation Disorders Hemic and Lymphatic Diseases
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006635 BXGD000402 Cadmium poisoning Chemically-Induced Disorders
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0011644 BXGD000744 Scleroderma Skin and Connective Tissue Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0016037 BXGD001035 Fibrodysplasia Ossificans Progressiva Musculoskeletal Diseases
C0016053 BXGD001041 Fibromyalgia Musculoskeletal Diseases; Nervous System Diseases
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019829 BXGD001350 Hodgkin Disease Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020550 BXGD001429 Hyperthyroidism Endocrine System Diseases
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0037274 BXGD002676 Dermatologic disorders Skin and Connective Tissue Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0042834 BXGD003004 Vital capacity
C0085138 BXGD003132 Choroid Plexus Neoplasms Neoplasms; Nervous System Diseases
C0151468 BXGD003424 Thyroid Gland Follicular Adenoma Neoplasms; Endocrine System Diseases
C0160390 BXGD003921 Injury of liver Digestive System Diseases; Wounds and Injuries
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205824 BXGD004128 Liposarcoma, Dedifferentiated Neoplasms
C0206682 BXGD004237 Follicular thyroid carcinoma Neoplasms
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0239981 BXGD005011 Hypoalbuminemia Hemic and Lymphatic Diseases
C0242339 BXGD005150 Dyslipidemias Nutritional and Metabolic Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0267375 BXGD005742 Chronic colitis Digestive System Diseases
C0278488 BXGD006515 Carcinoma breast stage IV
C0279606 BXGD006647 Childhood Hepatocellular Carcinoma Digestive System Diseases; Neoplasms
C0279607 BXGD006648 Adult Hepatocellular Carcinoma Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0521158 BXGD009130 Recurrent tumor
C0524910 BXGD009248 Hepatitis C, Chronic Digestive System Diseases; Infections
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0595921 BXGD009626 Intraocular pressure disorder Eye Diseases
C0595936 BXGD009628 Aqueous Humor Disorders Eye Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0752125 BXGD010673 Spinocerebellar Ataxia Type 7 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0856169 BXGD011096 Endothelial dysfunction
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1261473 BXGD011855 Sarcoma Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1300682 BXGD012281 Acute and chronic colitis Digestive System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1704272 BXGD013537 Benign Prostatic Hyperplasia Male Urogenital Diseases
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2826323 BXGD017790 Refractory Cytopenia of Childhood
C2919828 BXGD017881 Chronic ulcerative colitis Digestive System Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3839280 BXGD019772 High grade serous carcinoma
C4049711 BXGD021949 Lepidic Predominant Adenocarcinoma Neoplasms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4277682 BXGD022376 Chemical and Drug Induced Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4520983 BXGD023052 Congenital atresia of extrahepatic bile duct Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C4551687 BXGD023392 Sarcoma of soft tissue Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0002588 Magnesium 24.31
BXGC0002591 Potassium 39.1
BXGC0003705 Chloride 35.45
BXGC0005659 Arachidonic acid 304.47
BXGC0018397 beta-1,4-mannan 180.06
BXGC0027462 Damnacanthal 282.05
BXGC0045817 Congo Red 650.1
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein