Showing entry for Cyclin-dependent kinase 13


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013435
Protein NameCyclin-dependent kinase 13
Uniport IdQ14004
GeneCDK13
Gene Id8621
DomainPkinase
Pfam PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0000380 alternative mRNA splicing, via spliceosome
Biological Process GO:0030097 hemopoiesis
Biological Process GO:0007275 multicellular organism development
Biological Process GO:2000737 negative regulation of stem cell differentiation
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0070816 phosphorylation of RNA polymerase II C-terminal domain
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0007088 regulation of mitotic nuclear division
Biological Process GO:0006368 transcription elongation from RNA polymerase II promoter
Biological Process GO:0016032 viral process
molecular function GO:0005524 ATP binding
molecular function GO:0030332 cyclin binding
molecular function GO:0004693 cyclin-dependent protein serine/threonine kinase activity
molecular function GO:0004672 protein kinase activity
molecular function GO:0019901 protein kinase binding
molecular function GO:0003723 RNA binding
molecular function GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity
cellular component GO:0005694 chromosome
cellular component GO:0008024 cyclin/CDK positive transcription elongation factor complex
cellular component GO:0000307 cyclin-dependent protein kinase holoenzyme complex
cellular component GO:0002945 cyclin K-CDK13 complex
cellular component GO:0005829 cytosol
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:1904813 ficolin-1-rich granule lumen
cellular component GO:0005794 Golgi apparatus
cellular component GO:0000790 nuclear chromatin
cellular component GO:0019908 nuclear cyclin-dependent protein kinase holoenzyme complex
cellular component GO:0016607 nuclear speck
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-212436 Generic Transcription Pathway
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-HSA-6798695 Neutrophil degranulation
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0000772 BXGD000009 Multiple congenital anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0004045 BXGD000249 Asphyxia Neonatorum Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004106 BXGD000254 Astigmatism Eye Diseases
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0006325 BXGD000393 Bruxism Stomatognathic Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0008073 BXGD000518 Developmental Disabilities Mental Disorders
C0009081 BXGD000581 Congenital clubfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0009676 BXGD000619 Confusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0010034 BXGD000640 Corneal Diseases Eye Diseases
C0010200 BXGD000653 Coughing Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0013144 BXGD000800 Drowsiness Mental Disorders
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0018798 BXGD001223 Congenital Heart Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018817 BXGD001235 Atrial Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018818 BXGD001236 Ventricular Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0020224 BXGD001366 Polyhydramnios Female Urogenital Diseases and Pregnancy Complications
C0020458 BXGD001393 Hyperhidrosis disorder Skin and Connective Tissue Diseases
C0020534 BXGD001421 Orbital separation excessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0020580 BXGD001435 Hypesthesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0026034 BXGD001887 Microstomia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0026826 BXGD001935 Muscle Hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027092 BXGD001971 Myopia Eye Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0037317 BXGD002689 Sleep disturbances Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0086437 BXGD003282 Joint laxity Musculoskeletal Diseases
C0151818 BXGD003480 Opisthotonus Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0156394 BXGD003856 Hypertrophy of clitoris Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0162316 BXGD003936 Iron deficiency anemia Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0221358 BXGD004450 Long narrow head
C0221369 BXGD004453 Acquired Camptodactyly
C0231274 BXGD004490 Intolerant of heat
C0231471 BXGD004494 Abnormal posture Nervous System Diseases
C0232466 BXGD004543 Feeding difficulties
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0234853 BXGD004697 Facial grimacing
C0235991 BXGD004802 Small for gestational age (disorder) Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0239234 BXGD004974 Low set ears
C0239815 BXGD004996 Hand clenching
C0239998 BXGD005012 Recurrent infections Pathological Conditions, Signs and Symptoms; Infections; Musculoskeletal Diseases
C0241726 BXGD005110 Delayed ability to walk
C0265610 BXGD005555 Clinodactyly of fingers Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0266449 BXGD005670 Congenital anomaly of brain Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Nervous System Diseases
C0272386 BXGD006361 Hypertrophy of tonsils Pathological Conditions, Signs and Symptoms
C0338502 BXGD007192 Hypoplasia of the optic nerve Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0410264 BXGD008423 Contracture of tendo achilles
C0423109 BXGD008470 Upward slant of palpebral fissure
C0423112 BXGD008472 Short palpebral fissure
C0423798 BXGD008510 Increased tendency to bruise Wounds and Injuries
C0423808 BXGD008512 Brachyonychia
C0426886 BXGD008594 Tapering fingers (finding)
C0427086 BXGD008605 Involuntary Movements Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0431478 BXGD008692 Posteriorly rotated ear
C0432072 BXGD008718 Dysmorphic features
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0476217 BXGD008980 Head movements abnormal Nervous System Diseases
C0497202 BXGD009055 Abnormal ocular motility
C0544008 BXGD009306 Chandler syndrome Eye Diseases
C0549629 BXGD009393 Abnormal delivery
C0557874 BXGD009444 Global developmental delay
C0558165 BXGD009449 Curly hair (finding)
C0563243 BXGD009479 Poor coordination Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0575158 BXGD009515 Kyphoscoliosis deformity of spine Musculoskeletal Diseases
C0575802 BXGD009521 Small hand
C0578531 BXGD009548 Skin dimple
C0678230 BXGD009750 Congenital Epicanthus
C0685409 BXGD009810 Congenital Camptodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0740852 BXGD010011 Upper airway obstruction
C0741916 BXGD010044 Cardiac defects
C0751093 BXGD010317 Dystonia, Limb Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0850703 BXGD010905 Frequent falls Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0856975 BXGD011127 Autistic behavior Behavior and Behavior Mechanisms
C1264195 BXGD011913 Refractory anemia with ringed sideroblasts Hemic and Lymphatic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1562689 BXGD013376 Congenital hereditary endothelial dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1827524 BXGD013773 Wide spaced nipples
C1832160 BXGD013803 Abnormality of temperature regulation
C1835807 BXGD014051 Prominent fingertip pads
C1836038 BXGD014073 Poor head control Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1836830 BXGD014165 Developmental regression Mental Disorders
C1837404 BXGD014229 High, narrow palate
C1840077 BXGD014434 Anteverted nostril
C1848673 BXGD014963 Hypoplastic feet
C1849075 BXGD015002 Relative macrocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1849367 BXGD015046 Nasal bridge wide
C1850048 BXGD015100 Absent proximal finger flexion creases
C1850049 BXGD015101 Clinodactyly of the 5th finger
C1853241 BXGD015321 Flat face
C1854113 BXGD015382 Prominent nasal bridge
C1854114 BXGD015383 Short nose
C1854882 BXGD015439 Absent speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1855650 BXGD015521 Birth length less than 3rd percentile
C1856644 BXGD015625 Absent/hypoplastic coccyx
C1857569 BXGD015717 CORNEAL ENDOTHELIAL DYSTROPHY 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1857572 BXGD015718 CORNEAL DYSTROPHY AND PERCEPTIVE DEAFNESS Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1858565 BXGD015807 Duplicated collecting system
C1860247 BXGD015973 Prominent glabella
C1861324 BXGD016029 Short philtrum
C1865017 BXGD016283 Thin upper lip vermilion
C1865304 BXGD016309 Overfolding of the superior helices
C1868571 BXGD016508 Highly arched eyebrow
C1956257 BXGD016623 Pulmonary Stenosis Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2315100 BXGD017021 Pediatric failure to thrive Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Mental Disorders
C2700617 BXGD017474 Irritation - emotion Behavior and Behavior Mechanisms
C2751480 BXGD017716 Hypoplastic coccygeal vertebrae
C2826330 BXGD017791 Refractory anemia with ring sideroblasts associated with marked thrombocytosis Hemic and Lymphatic Diseases
C3278923 BXGD018748 Dilated ventricles (finding)
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3806467 BXGD019513 Respiratory insufficiency due to muscle weakness Respiratory Tract Diseases
C3808403 BXGD019546 Large fleshy ears
C3809827 BXGD019614 Staring gaze
C4021161 BXGD020568 Multiple suture craniosynostosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C4022490 BXGD020906 Prominent coccyx
C4022735 BXGD020971 Cerebral white matter atrophy Pathological Conditions, Signs and Symptoms
C4023342 BXGD021158 Gastrostomy tube feeding in infancy
C4024946 BXGD021493 Focal white matter lesions Pathological Conditions, Signs and Symptoms
C4049796 BXGD021951 Abnormality of cardiovascular system morphology Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4072903 BXGD022020 Primary Caesarian section
C4281993 BXGD022418 Neonatal respiratory distress Respiratory Tract Diseases
C4479246 BXGD022928 CONGENITAL HEART DEFECTS, DYSMORPHIC FACIAL FEATURES, AND INTELLECTUAL DEVELOPMENTAL DISORDER
C4551485 BXGD023312 Clinodactyly
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0040305 Indirubin 262.07
BXGC0047692 Gefitinib 446.15
BXGC0050099 (2E,5S,6S,8Z,11S)-5,6,15-Trihydroxy-17-Methoxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),2,8,15,17-Pentaene-7,13-Dione 362.14
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein