Showing entry for Translation initiation factor eIF-2B subunit alpha


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013457
Protein NameTranslation initiation factor eIF-2B subunit alpha
Uniport IdQ14232
GeneEIF2B1
Gene Id1967
DomainIF-2B
Pfam PF01008  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.2 Translation hsa03013 RNA transport
6. Human Diseases 6.9 Infectious diseases: Viral hsa05168 Herpes simplex virus 1 infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0014003 oligodendrocyte development
Biological Process GO:0006446 regulation of translational initiation
Biological Process GO:0009749 response to glucose
Biological Process GO:0009408 response to heat
Biological Process GO:0043434 response to peptide hormone
Biological Process GO:0050852 T cell receptor signaling pathway
Biological Process GO:0006413 translational initiation
molecular function GO:0042802 identical protein binding
molecular function GO:0003743 translation initiation factor activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005851 eukaryotic translation initiation factor 2B complex
cellular component GO:0016020 membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-392499 Metabolism of proteins
R-HSA-72613 Eukaryotic Translation Initiation
R-HSA-72731 Recycling of eIF2:GDP
R-HSA-72737 Cap-dependent Translation Initiation
R-HSA-72766 Translation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0006111 BXGD000369 Brain Diseases Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0008073 BXGD000518 Developmental Disabilities Mental Disorders
C0011253 BXGD000706 Delusions Behavior and Behavior Mechanisms
C0011644 BXGD000744 Scleroderma Skin and Connective Tissue Diseases
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0017639 BXGD001133 Gliosis Pathological Conditions, Signs and Symptoms
C0023281 BXGD001628 Leishmaniasis Infections; Skin and Connective Tissue Diseases
C0023380 BXGD001640 Lethargy Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0023520 BXGD001678 Leukodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0025322 BXGD001863 Premature Menopause Female Urogenital Diseases and Pregnancy Complications
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0085215 BXGD003141 Ovarian Failure, Premature Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0085633 BXGD003216 Mood swings Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0206062 BXGD004148 Lung Diseases, Interstitial Respiratory Tract Diseases
C0221355 BXGD004447 Macrocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0231686 BXGD004508 Gait, Unsteady Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0232939 BXGD004568 Primary physiologic amenorrhea Pathological Conditions, Signs and Symptoms
C0232940 BXGD004569 Secondary physiologic amenorrhea Pathological Conditions, Signs and Symptoms
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0240735 BXGD005052 Personality Change Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0270612 BXGD006081 Leukoencephalopathy Nervous System Diseases
C0338474 BXGD007183 Central nervous system demyelination
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0425957 BXGD008555 Secondary amenorrhea Pathological Conditions, Signs and Symptoms
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0542476 BXGD009276 Forgetful Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0575081 BXGD009512 Gait abnormality Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1258104 BXGD011823 Diffuse Scleroderma Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1836830 BXGD014165 Developmental regression Mental Disorders
C1847967 BXGD014898 OVARIOLEUKODYSTROPHY Female Urogenital Diseases and Pregnancy Complications; Nervous System Diseases; Endocrine System Diseases
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1858991 BXGD015841 Childhood Ataxia with Central Nervous System Hypomyelinization Nervous System Diseases
C1858995 BXGD015842 Decreased circulating progesterone
C1859014 BXGD015843 Primary gonadal insufficiency
C1963167 BXGD016686 Memory Impairment, CTCAE 3.0
C2677328 BXGD017371 Cerebral hypomyelination
C2960129 BXGD018198 Vanishing white matter disease Nervous System Diseases
C4025319 BXGD021642 Cessation of head growth
C4521042 BXGD023055 Complete Trisomy 21 Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4551915 BXGD023441 Gait Disturbance, CTCAE
C4553743 BXGD023548 Spasticity, CTCAE
C4553765 BXGD023551 Memory Impairment, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein