Showing entry for Frizzled-2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013462
Protein NameFrizzled-2
Uniport IdQ14332
GeneFZD2
Gene Id2535
DomainFrizzled; Fz
Pfam PF01534   PF01392  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04150 mTOR signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04310 Wnt signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04390 Hippo signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04550 Signaling pathways regulating pluripotency of stem cells
5. Organismal Systems 5.2 Endocrine system hsa04916 Melanogenesis
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04934 Cushing syndrome
6. Human Diseases 6.9 Infectious diseases: Viral hsa05165 Human papillomavirus infection
6. Human Diseases 6.1 Cancers: Overview hsa05200 Pathways in cancer
6. Human Diseases 6.1 Cancers: Overview hsa05205 Proteoglycans in cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05217 Basal cell carcinoma
6. Human Diseases 6.2 Cancers: Specific types hsa05224 Breast cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05225 Hepatocellular carcinoma
6. Human Diseases 6.2 Cancers: Specific types hsa05226 Gastric cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:1904886 beta-catenin destruction complex disassembly
Biological Process GO:0060070 canonical Wnt signaling pathway
Biological Process GO:0090103 cochlea morphogenesis
Biological Process GO:0030855 epithelial cell differentiation
Biological Process GO:0060022 hard palate development
Biological Process GO:0060119 inner ear receptor cell development
Biological Process GO:0003149 membranous septum morphogenesis
Biological Process GO:0003150 muscular septum morphogenesis
Biological Process GO:0030182 neuron differentiation
Biological Process GO:0003151 outflow tract morphogenesis
Biological Process GO:0090179 planar cell polarity pathway involved in neural tube closure
Biological Process GO:0051091 positive regulation of DNA-binding transcription factor activity
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0007608 sensory perception of smell
Biological Process GO:0016055 Wnt signaling pathway
Biological Process GO:0007223 Wnt signaling pathway, calcium modulating pathway
Biological Process GO:0060071 Wnt signaling pathway, planar cell polarity pathway
molecular function GO:0004930 G protein-coupled receptor activity
molecular function GO:0030165 PDZ domain binding
molecular function GO:0042813 Wnt-activated receptor activity
molecular function GO:0017147 Wnt-protein binding
cellular component GO:0030669 clathrin-coated endocytic vesicle membrane
cellular component GO:0005737 cytoplasm
cellular component GO:0005925 focal adhesion
cellular component GO:0016021 integral component of membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-195721 Signaling by WNT
R-HSA-195721 Signaling by WNT
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-372790 Signaling by GPCR
R-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-3858494 Beta-catenin independent WNT signaling
R-HSA-3858494 Beta-catenin independent WNT signaling
R-HSA-4086398 Ca2+ pathway
R-HSA-4086398 Ca2+ pathway
R-HSA-4086400 PCP/CE pathway
R-HSA-4608870 Asymmetric localization of PCP proteins
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-HSA-500792 GPCR ligand binding
R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001815 BXGD000078 Primary Myelofibrosis Hemic and Lymphatic Diseases
C0002170 BXGD000105 Alopecia Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0010606 BXGD000677 Adenoid Cystic Carcinoma Neoplasms
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0014588 BXGD000937 Epispadias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0015300 BXGD000973 Exophthalmos Eye Diseases
C0016842 BXGD001083 Congenital pectus excavatum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0019288 BXGD001313 Hernia, Femoral Pathological Conditions, Signs and Symptoms
C0019294 BXGD001314 Hernia, Inguinal Pathological Conditions, Signs and Symptoms
C0020534 BXGD001421 Orbital separation excessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0020608 BXGD001443 Hypodontia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0023234 BXGD001622 Legg-Calve-Perthes Disease Musculoskeletal Diseases
C0023267 BXGD001626 Fibroid Tumor Neoplasms
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0025995 BXGD001885 Micromelia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0026987 BXGD001957 Myelofibrosis Pathological Conditions, Signs and Symptoms; Neoplasms; Hemic and Lymphatic Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029422 BXGD002142 Osteochondrodysplasias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0032580 BXGD002362 Adenomatous Polyposis Coli Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0040457 BXGD002867 Tooth, Supernumerary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0042133 BXGD002960 Uterine Fibroids Neoplasms
C0149721 BXGD003349 Left Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0153349 BXGD003621 Malignant neoplasm of tongue Neoplasms; Stomatognathic Diseases
C0158731 BXGD003902 Congenital pectus carinatum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0206733 BXGD004278 Strawberry nevus of skin Neoplasms
C0221352 BXGD004444 Syndactyly of fingers Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases
C0221354 BXGD004446 Frontal bossing Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0221355 BXGD004447 Macrocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0221357 BXGD004449 Brachydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0235833 BXGD004775 Congenital diaphragmatic hernia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0239137 BXGD004965 Coxa valga Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0239138 BXGD004966 Hip joint varus deformity - observation Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0239234 BXGD004974 Low set ears
C0265205 BXGD005462 Robinow Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases; Male Urogenital Diseases; Endocrine System Diseases
C0265563 BXGD005550 Congenital dislocation of radial head Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0265677 BXGD005564 Congenital hemivertebra Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0266061 BXGD005618 Open Bite Stomatognathic Diseases
C0266111 BXGD005620 Bifid tongue Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0266362 BXGD005657 Ambiguous Genitalia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0266435 BXGD005668 Congenital hypoplasia of penis Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0266617 BXGD005700 Congenital anomaly of face Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0341787 BXGD007422 Bifid scrotum
C0346957 BXGD007836 Disseminated Malignant Neoplasm Neoplasms
C0349566 BXGD007928 Squamous cell carcinoma of tongue Neoplasms; Stomatognathic Diseases
C0349588 BXGD007933 Short stature
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376480 BXGD007998 Gingival Overgrowth Stomatognathic Diseases
C0399352 BXGD008236 Developmental absence of tooth Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0409348 BXGD008384 Flexion contracture of proximal interphalangeal joint
C0410528 BXGD008430 Skeletal dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0423109 BXGD008470 Upward slant of palpebral fissure
C0423110 BXGD008471 Downward slant of palpebral fissure
C0426421 BXGD008561 Wide nose
C0426428 BXGD008563 Bifid nasal tip
C0426848 BXGD008590 Sacral dimple Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0431380 BXGD008680 Cortical Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0431478 BXGD008692 Posteriorly rotated ear
C0521525 BXGD009139 Short neck
C0542514 BXGD009277 Blue sclera Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0557874 BXGD009444 Global developmental delay
C0558353 BXGD009451 Tongue Carcinoma Neoplasms; Stomatognathic Diseases
C0559483 BXGD009472 Pentalogy of Cantrell Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0566899 BXGD009494 Small labia majora
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678230 BXGD009750 Congenital Epicanthus
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0848558 BXGD010882 Hypospadias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1303001 BXGD012317 Congenital euryblepharon
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306503 BXGD012363 Congenital exomphalos Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1328407 BXGD012465 Hip Dysplasia Musculoskeletal Diseases; Wounds and Injuries
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1387005 BXGD012953 Penis agenesis Male Urogenital Diseases
C1442965 BXGD013064 Avascular necrosis of the capital femoral epiphysis Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1832117 BXGD013798 Short humerus
C1836542 BXGD014129 Depressed nasal bridge
C1837260 BXGD014214 Prominent forehead
C1837404 BXGD014229 High, narrow palate
C1840077 BXGD014434 Anteverted nostril
C1843108 BXGD014556 Short palm
C1844527 BXGD014640 Clitoral hypoplasia
C1849295 BXGD015031 Hypoplastic labia minora
C1849311 BXGD015034 Short 1st metacarpal
C1849340 BXGD015039 Long palpebral fissure
C1849367 BXGD015046 Nasal bridge wide
C1849392 BXGD015047 Ridged fingernail
C1850049 BXGD015101 Clinodactyly of the 5th finger
C1853242 BXGD015322 Midface retrusion
C1853738 BXGD015357 Long eyelashes
C1854114 BXGD015383 Short nose
C1854409 BXGD015398 Naevus flammeus of the eyelid Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1858085 BXGD015770 Malar flattening
C1861324 BXGD016029 Short philtrum
C1865014 BXGD016282 Long philtrum
C1866195 BXGD016385 Downturned corners of mouth
C1866730 BXGD016419 Rhizomelia
C1968605 BXGD016719 Limited elbow flexion/extension
C1968607 BXGD016721 Hypoplastic distal humeri
C1969532 BXGD016779 Rhizomelic arm shortening
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2673670 BXGD017220 Curly eyelashes
C2750355 BXGD017657 Omodysplasia 2 Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C2750604 BXGD017672 Median cleft lip and palate
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3494422 BXGD018966 Retrognathia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3888788 BXGD019984 Minimal hepatic encephalopathy
C4020952 BXGD020505 Fingernail dysplasia
C4022477 BXGD020902 Onychogryposis of fingernail
C4025790 BXGD021791 Specific learning disability
C4082304 BXGD022090 Oligodontia
C4225164 BXGD022165 ROBINOW SYNDROME, AUTOSOMAL DOMINANT 3
C4225363 BXGD022241 ROBINOW SYNDROME, AUTOSOMAL DOMINANT 2
C4510897 BXGD022990 Omodysplasia
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002825 Hexadecenoic acid 254.41
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein