protein

Showing entry for ATP-sensitive inward rectifier potassium channel 12

　　　　　　　　　　　　

General Target Information
BXGT Id	BXGT013477
Protein Name	ATP-sensitive inward rectifier potassium channel 12
Uniport Id	Q14500
Gene	KCNJ12
Gene Id	3768
Domain	IRK; IRK_C; IRK_N
Pfam	PF01007 PF17655 PF08466
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
5. Organismal Systems	5.6 Nervous system	hsa04725	Cholinergic synapse
5. Organismal Systems	5.2 Endocrine system	hsa04921	Oxytocin signaling pathway

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0061337	cardiac conduction
Biological Process	GO:0006936	muscle contraction
Biological Process	GO:1990573	potassium ion import across plasma membrane
Biological Process	GO:0006813	potassium ion transport
Biological Process	GO:0051289	protein homotetramerization
Biological Process	GO:0008016	regulation of heart contraction
Biological Process	GO:0034765	regulation of ion transmembrane transport
molecular function	GO:0005242	inward rectifier potassium channel activity
cellular component	GO:0016021	integral component of membrane
cellular component	GO:0031224	intrinsic component of membrane
cellular component	GO:0005886	plasma membrane

Reactome

Pathway Id	Pathway Name
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315	Transmission across Chemical Synapses
R-HSA-112316	Neuronal System
R-HSA-1296041	Activation of G protein gated Potassium channels
R-HSA-1296053	Classical Kir channels
R-HSA-1296059	G protein gated Potassium channels
R-HSA-1296065	Inwardly rectifying K+ channels
R-HSA-1296071	Potassium Channels
R-HSA-397014	Muscle contraction
R-HSA-5576886	Phase 4 - resting membrane potential
R-HSA-5576891	Cardiac conduction
R-HSA-977443	GABA receptor activation
R-HSA-977444	GABA B receptor activation
R-HSA-991365	Activation of GABAB receptors
R-HSA-997272	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0005890	BXGD000345	Body Height
C0014772	BXGD000948	Red Blood Cell Count measurement
C0017923	BXGD001154	Glycogen Storage Disease Type IV	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0019569	BXGD001337	Hirschsprung Disease	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0027651	BXGD002009	Neoplasms	Neoplasms
C0205682	BXGD004105	Waist-Hip Ratio
C0340427	BXGD007329	Familial dilated cardiomyopathy	Cardiovascular Diseases
C0489786	BXGD009018	Height
C1449563	BXGD013086	Cardiomyopathy, Familial Idiopathic	Cardiovascular Diseases
C1563715	BXGD013389	Andersen Syndrome	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0046755	Yohimbine		354.19

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}