Showing entry for Indian hedgehog protein


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013490
Protein NameIndian hedgehog protein
Uniport IdQ14623
GeneIHH
Gene Id3549
DomainHH_signal; Hint
Pfam PF01085   PF01079  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04340 Hedgehog signaling pathway
6. Human Diseases 6.1 Cancers: Overview hsa05205 Proteoglycans in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0045453 bone resorption
Biological Process GO:0001569 branching involved in blood vessel morphogenesis
Biological Process GO:0060220 camera-type eye photoreceptor cell fate commitment
Biological Process GO:0051216 cartilage development
Biological Process GO:0007267 cell-cell signaling
Biological Process GO:0001708 cell fate specification
Biological Process GO:0048469 cell maturation
Biological Process GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis
Biological Process GO:0035988 chondrocyte proliferation
Biological Process GO:0048596 embryonic camera-type eye morphogenesis
Biological Process GO:0048557 embryonic digestive tract morphogenesis
Biological Process GO:0042733 embryonic digit morphogenesis
Biological Process GO:0009880 embryonic pattern specification
Biological Process GO:0072498 embryonic skeletal joint development
Biological Process GO:0090136 epithelial cell-cell adhesion
Biological Process GO:0003382 epithelial cell morphogenesis
Biological Process GO:0060323 head morphogenesis
Biological Process GO:0001947 heart looping
Biological Process GO:0016539 intein-mediated protein splicing
Biological Process GO:0001701 in utero embryonic development
Biological Process GO:0097421 liver regeneration
Biological Process GO:0060135 maternal process involved in female pregnancy
Biological Process GO:0035264 multicellular organism growth
Biological Process GO:0046639 negative regulation of alpha-beta T cell differentiation
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0048074 negative regulation of eye pigmentation
Biological Process GO:0033088 negative regulation of immature T cell proliferation in thymus
Biological Process GO:0033085 negative regulation of T cell differentiation in thymus
Biological Process GO:0048666 neuron development
Biological Process GO:0001649 osteoblast differentiation
Biological Process GO:0031016 pancreas development
Biological Process GO:0046638 positive regulation of alpha-beta T cell differentiation
Biological Process GO:0032967 positive regulation of collagen biosynthetic process
Biological Process GO:0050679 positive regulation of epithelial cell proliferation
Biological Process GO:0002053 positive regulation of mesenchymal cell proliferation
Biological Process GO:0045880 positive regulation of smoothened signaling pathway
Biological Process GO:0033089 positive regulation of T cell differentiation in thymus
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0016540 protein autoprocessing
Biological Process GO:0006029 proteoglycan metabolic process
Biological Process GO:0010468 regulation of gene expression
Biological Process GO:0040008 regulation of growth
Biological Process GO:0032355 response to estradiol
Biological Process GO:0009612 response to mechanical stimulus
Biological Process GO:0003406 retinal pigment epithelium development
Biological Process GO:0001501 skeletal system development
Biological Process GO:0007224 smoothened signaling pathway
Biological Process GO:0048745 smooth muscle tissue development
Biological Process GO:0061053 somite development
Biological Process GO:0030704 vitelline membrane formation
molecular function GO:0005509 calcium ion binding
molecular function GO:0005113 patched binding
molecular function GO:0008233 peptidase activity
cellular component GO:0031012 extracellular matrix
cellular component GO:0005615 extracellular space
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-212436 Generic Transcription Pathway
R-HSA-372790 Signaling by GPCR
R-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-500792 GPCR ligand binding
R-HSA-5358346 Hedgehog ligand biogenesis
R-HSA-5358346 Hedgehog ligand biogenesis
R-HSA-5358351 Signaling by Hedgehog
R-HSA-5358351 Signaling by Hedgehog
R-HSA-5362798 Release of Hh-Np from the secreting cell
R-HSA-5362798 Release of Hh-Np from the secreting cell
R-HSA-5387390 Hh mutants abrogate ligand secretion
R-HSA-5632681 Ligand-receptor interactions
R-HSA-5632681 Ligand-receptor interactions
R-HSA-5632684 Hedgehog 'on' state
R-HSA-5632684 Hedgehog 'on' state
R-HSA-5635838 Activation of SMO
R-HSA-5658034 HHAT G278V abrogates palmitoylation of Hh-Np
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-8878166 Transcriptional regulation by RUNX2
R-HSA-8941284 RUNX2 regulates chondrocyte maturation
R-HSA-8941326 RUNX2 regulates bone development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001430 BXGD000054 Adenoma Neoplasms
C0005890 BXGD000345 Body Height
C0005940 BXGD000352 Bone Diseases Musculoskeletal Diseases
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0008479 BXGD000544 Chondrosarcoma Neoplasms
C0009081 BXGD000581 Congenital clubfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010093 BXGD000652 Corpus Luteum Cyst Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0010278 BXGD000660 Craniosynostosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0016842 BXGD001083 Congenital pectus excavatum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0019569 BXGD001337 Hirschsprung Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0024003 BXGD001726 Lordosis Musculoskeletal Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025160 BXGD001827 Megacolon Digestive System Diseases
C0025995 BXGD001885 Micromelia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027709 BXGD002026 Nephrocalcinosis Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029422 BXGD002142 Osteochondrodysplasias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0029423 BXGD002143 Cartilaginous exostosis Neoplasms; Musculoskeletal Diseases
C0029927 BXGD002182 Ovarian Cysts Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0030297 BXGD002204 Pancreatic Neoplasm Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0032580 BXGD002362 Adenomatous Polyposis Coli Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms
C0033375 BXGD002405 Prolactinoma Neoplasms; Nervous System Diseases; Endocrine System Diseases
C0035344 BXGD002541 Retinopathy of Prematurity Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0149782 BXGD003365 Squamous cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0149955 BXGD003394 Annular pancreas Digestive System Diseases
C0152021 BXGD003520 Congenital heart disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0157946 BXGD003873 Osteoarthrosis, localized, not specified whether primary or secondary Musculoskeletal Diseases
C0158731 BXGD003902 Congenital pectus carinatum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0162809 BXGD003981 Kallmann Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0206637 BXGD004202 Mesenchymal Chondrosarcoma Neoplasms
C0221355 BXGD004447 Macrocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0221357 BXGD004449 Brachydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0234362 BXGD004651 Synkinesis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0238198 BXGD004893 Gastrointestinal Stromal Tumors Digestive System Diseases; Neoplasms
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0239138 BXGD004966 Hip joint varus deformity - observation Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0263523 BXGD005320 Micronychia (disorder) Skin and Connective Tissue Diseases
C0264142 BXGD005368 Spade-like hand Musculoskeletal Diseases
C0269102 BXGD006053 Endometrioma Female Urogenital Diseases and Pregnancy Complications
C0302142 BXGD006831 Deformity Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0333983 BXGD006975 Hyperplastic Polyp Pathological Conditions, Signs and Symptoms
C0342384 BXGD007470 Idiopathic hypogonadotropic hypogonadism Endocrine System Diseases
C0345375 BXGD007730 Congenital hypoplasia of femur Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0349588 BXGD007933 Short stature
C0399352 BXGD008236 Developmental absence of tooth Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0399526 BXGD008251 Class III malocclusion Stomatognathic Diseases
C0410528 BXGD008430 Skeletal dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0410530 BXGD008432 Metachondromatosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Musculoskeletal Diseases
C0426789 BXGD008576 Short thorax
C0426790 BXGD008577 Narrow thorax
C0426817 BXGD008585 Short ribs
C0431890 BXGD008712 Hypoplasia of thumb Musculoskeletal Diseases
C0432282 BXGD008763 Dysplasia epiphysealis hemimelica Musculoskeletal Diseases
C0541764 BXGD009259 Delayed bone age
C0544755 BXGD009310 Genu varum Musculoskeletal Diseases
C0553580 BXGD009399 Ewings sarcoma Neoplasms
C0575827 BXGD009523 Small finger
C0576226 BXGD009527 Short foot
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0685381 BXGD009809 Congenital hypoplasia of radius Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0750952 BXGD010263 Biliary Tract Cancer Digestive System Diseases; Neoplasms
C0878659 BXGD011380 Disproportionate short stature Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C1184923 BXGD011800 Lumbar hyperlordosis Musculoskeletal Diseases
C1302401 BXGD012303 Adenoma of large intestine Digestive System Diseases; Neoplasms
C1608408 BXGD013434 Malignant transformation
C1832117 BXGD013798 Short humerus
C1832590 BXGD013858 Craniosynostosis, Philadelphia Type Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1836184 BXGD014088 Short femoral neck
C1837084 BXGD014195 Short metacarpal
C1839829 BXGD014413 Short distal phalanx of finger
C1841684 BXGD014481 Delayed ossification of carpal bones
C1842229 BXGD014505 Broad metacarpals
C1843096 BXGD014554 Acrocapitofemoral Dysplasia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1843105 BXGD014555 Enlargement of the distal femoral epiphysis
C1843108 BXGD014556 Short palm
C1843112 BXGD014557 Broad nail
C1844709 BXGD014667 Radial deviation of the 2nd finger
C1846157 BXGD014789 Cone-shaped capital femoral epiphysis
C1846950 BXGD014848 Short middle phalanx of finger
C1848673 BXGD014963 Hypoplastic feet
C1849075 BXGD015002 Relative macrocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1849937 BXGD015091 Disproportionate short-limb short stature
C1850049 BXGD015101 Clinodactyly of the 5th finger
C1850259 BXGD015125 Short tibia
C1855091 BXGD015456 Short proximal phalanx of thumb
C1855239 BXGD015477 Cone-shaped metacarpal epiphyses
C1855665 BXGD015524 Ovoid vertebral bodies
C1860606 BXGD015989 Short proximal phalanx of finger
C1860614 BXGD015992 ULNAR HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1861349 BXGD016037 Absent distal interphalangeal creases
C1861380 BXGD016042 Syndactyly, Type I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1862151 BXGD016110 BRACHYDACTYLY, TYPE A1 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1862157 BXGD016111 Proportionate shortening of all digits
C1862158 BXGD016112 Terminal symphalangism of hands Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1862159 BXGD016113 Short proximal phalanx of hallux
C1863307 BXGD016161 Acropectorovertebral Dysplasia, F-Form Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1864298 BXGD016222 Fibular overgrowth
C1865027 BXGD016287 Hypoplastic iliac wing
C1865037 BXGD016289 Cone-shaped epiphysis
C1865039 BXGD016291 Cupped ribs
C1865841 BXGD016343 Flared iliac wings
C1865992 BXGD016359 Short hallux
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2919142 BXGD017867 Short Stature, CTCAE
C3179349 BXGD018550 Gastrointestinal Stromal Sarcoma Digestive System Diseases; Neoplasms
C3266843 BXGD018604 47, XYY syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C3888239 BXGD019962 HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 1
C4021251 BXGD020597 Dysplasia of the femoral head
C4024106 BXGD021289 Cone-shaped epiphysis of the 1st metacarpal
C4024345 BXGD021321 Radial deviation of the 3rd finger
C4024473 BXGD021325 Radial deviation of the 4th finger
C4025077 BXGD021544 Slender metacarpals
C4025079 BXGD021546 Thin proximal phalanges with broad epiphyses of the hand
C4025088 BXGD021551 Broad metacarpal epiphyses
C4025240 BXGD021602 Flattened metatarsal heads
C4225399 BXGD022262 SHORT STATURE WITH NONSPECIFIC SKELETAL ABNORMALITIES
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0003533 Carbonate 60.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein