Showing entry for Potassium voltage-gated channel subfamily B member 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013502
Protein NamePotassium voltage-gated channel subfamily B member 1
Uniport IdQ14721
GeneKCNB1
Gene Id3745
DomainBTB_2; Ion_trans; Kv2channel
Pfam PF02214   PF00520   PF03521  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0001508 action potential
Biological Process GO:0071333 cellular response to glucose stimulus
Biological Process GO:0031669 cellular response to nutrient levels
Biological Process GO:0042593 glucose homeostasis
Biological Process GO:0007215 glutamate receptor signaling pathway
Biological Process GO:0046676 negative regulation of insulin secretion
Biological Process GO:0045956 positive regulation of calcium ion-dependent exocytosis
Biological Process GO:0033605 positive regulation of catecholamine secretion
Biological Process GO:1900454 positive regulation of long-term synaptic depression
Biological Process GO:0010701 positive regulation of norepinephrine secretion
Biological Process GO:0090314 positive regulation of protein targeting to membrane
Biological Process GO:0071805 potassium ion transmembrane transport
Biological Process GO:0051260 protein homooligomerization
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:0098900 regulation of action potential
Biological Process GO:0050796 regulation of insulin secretion
Biological Process GO:0034765 regulation of ion transmembrane transport
Biological Process GO:2000671 regulation of motor neuron apoptotic process
Biological Process GO:0006904 vesicle docking involved in exocytosis
molecular function GO:0005251 delayed rectifier potassium channel activity
molecular function GO:0044325 ion channel binding
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0005249 voltage-gated potassium channel activity
cellular component GO:0030424 axon
cellular component GO:0030425 dendrite
cellular component GO:0032590 dendrite membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0016328 lateral plasma membrane
cellular component GO:0032809 neuronal cell body membrane
cellular component GO:0043204 perikaryon
cellular component GO:0005886 plasma membrane
cellular component GO:0045211 postsynaptic membrane
cellular component GO:0042383 sarcolemma
cellular component GO:0008076 voltage-gated potassium channel complex
Reactome
Pathway Id Pathway Name
R-HSA-112316 Neuronal System
R-HSA-1296071 Potassium Channels
R-HSA-1296072 Voltage gated Potassium channels
R-HSA-1430728 Metabolism
R-HSA-163685 Integration of energy metabolism
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-422356 Regulation of insulin secretion
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0005890 BXGD000345 Body Height
C0006325 BXGD000393 Bruxism Stomatognathic Diseases
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013384 BXGD000826 Dyskinetic syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0017168 BXGD001101 Gastroesophageal reflux disease Digestive System Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0019284 BXGD001312 Diaphragmatic Hernia Pathological Conditions, Signs and Symptoms
C0020608 BXGD001443 Hypodontia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0021125 BXGD001483 Impulsive Behavior Behavior and Behavior Mechanisms
C0021704 BXGD001510 Intelligence Behavior and Behavior Mechanisms
C0023976 BXGD001724 Long QT Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026837 BXGD001937 Muscle Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026946 BXGD001951 Mycoses Infections
C0027066 BXGD001966 Myoclonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0035304 BXGD002528 Retinal Degeneration Eye Diseases
C0035372 BXGD002544 Rett Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0085207 BXGD003140 Gestational Diabetes Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0149721 BXGD003349 Left Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0231686 BXGD004508 Gait, Unsteady Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0232466 BXGD004543 Feeding difficulties
C0234533 BXGD004687 Generalized seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0235659 BXGD004763 Reduced fetal movement Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0235946 BXGD004789 Cerebral atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0239676 BXGD004989 High forehead
C0311394 BXGD006884 Difficulty walking Pathological Conditions, Signs and Symptoms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0349588 BXGD007933 Short stature
C0423110 BXGD008471 Downward slant of palpebral fissure
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0428883 BXGD008639 Diastolic blood pressure
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0521857 BXGD009185 Increased drug resistance
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0543888 BXGD009300 Epileptic encephalopathy Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0596887 BXGD009648 mathematical ability
C0684276 BXGD009793 Hypsarrhythmia Nervous System Diseases
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1836038 BXGD014073 Poor head control Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1836830 BXGD014165 Developmental regression Mental Disorders
C1838391 BXGD014313 Limb hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1842581 BXGD014525 Abnormal corpus callosum morphology Pathological Conditions, Signs and Symptoms
C1843367 BXGD014576 Poor school performance
C1854882 BXGD015439 Absent speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1857704 BXGD015741 Abnormal myelination
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2919142 BXGD017867 Short Stature, CTCAE
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4015119 BXGD020185 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 26
C4022901 BXGD021032 Low CSF 5-methyltetrahydrofolate
C4023512 BXGD021207 Myoclonic absences
C4023687 BXGD021243 EEG with multifocal slow activity
C4025846 BXGD021826 Abnormality of vision
C4553743 BXGD023548 Spasticity, CTCAE
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0047867 Dalfampridine 94.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein