Showing entry for Eukaryotic translation initiation factor 4H


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013529
Protein NameEukaryotic translation initiation factor 4H
Uniport IdQ15056
GeneEIF4H
Gene Id7458
DomainRRM_1
Pfam PF00076  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002181 cytoplasmic translation
Biological Process GO:0048589 developmental growth
Biological Process GO:0097010 eukaryotic translation initiation factor 4F complex assembly
Biological Process GO:0001731 formation of translation preinitiation complex
Biological Process GO:0006446 regulation of translational initiation
Biological Process GO:0019953 sexual reproduction
Biological Process GO:0006413 translational initiation
Biological Process GO:0016032 viral process
molecular function GO:0045296 cadherin binding
molecular function GO:0043024 ribosomal small subunit binding
molecular function GO:0003723 RNA binding
molecular function GO:0033592 RNA strand annealing activity
molecular function GO:0034057 RNA strand-exchange activity
molecular function GO:0008135 translation factor activity, RNA binding
molecular function GO:0003743 translation initiation factor activity
cellular component GO:0005829 cytosol
cellular component GO:0016281 eukaryotic translation initiation factor 4F complex
cellular component GO:0016020 membrane
cellular component GO:0048471 perinuclear region of cytoplasm
Reactome
Pathway Id Pathway Name
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-392499 Metabolism of proteins
R-HSA-72613 Eukaryotic Translation Initiation
R-HSA-72649 Translation initiation complex formation
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72737 Cap-dependent Translation Initiation
R-HSA-72766 Translation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0019348 BXGD001325 Herpes Simplex Infections Infections; Skin and Connective Tissue Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0175702 BXGD004008 Williams Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Cardiovascular Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1519689 BXGD013245 Tumor Promotion Pathological Conditions, Signs and Symptoms; Neoplasms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0004322 xi-3-Hydroxy-5-phenylpentanoic acid O-beta-D-Glucopyranoside 356.37
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein