Showing entry for Phosphomevalonate kinase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013544
Protein NamePhosphomevalonate kinase
Uniport IdQ15126
GenePMVK
Gene Id10654
DomainP-mevalo_kinase
Pfam PF04275  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.9 Metabolism of terpenoids and polyketides hsa00900 Terpenoid backbone biosynthesis
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
4. Cellular Processes 4.1 Transport and catabolism hsa04146 Peroxisome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006695 cholesterol biosynthetic process
Biological Process GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway
Biological Process GO:0045540 regulation of cholesterol biosynthetic process
Biological Process GO:0070723 response to cholesterol
Biological Process GO:0016126 sterol biosynthetic process
molecular function GO:0005524 ATP binding
molecular function GO:0004631 phosphomevalonate kinase activity
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0016020 membrane
cellular component GO:0005777 peroxisome
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-HSA-191273 Cholesterol biosynthesis
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-556833 Metabolism of lipids
R-HSA-8957322 Metabolism of steroids
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0030436 BXGD002221 Parakeratosis Skin and Connective Tissue Diseases
C0033774 BXGD002419 Pruritus Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0037286 BXGD002681 Skin Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0162839 BXGD003991 Porokeratosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0268155 BXGD005840 Deficiency of galactokinase Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0302319 BXGD006838 Porokeratosis, Linear Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0342731 BXGD007535 Deficiency of mevalonate kinase Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Nervous System Diseases; Hemic and Lymphatic Diseases
C0349506 BXGD007912 Photosensitivity of skin Skin and Connective Tissue Diseases
C0521707 BXGD009166 Bilateral cataracts (disorder) Eye Diseases
C0870082 BXGD011309 Hyperkeratosis Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0949506 BXGD011577 Porokeratosis of Mibelli Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1611743 BXGD013456 Familial (FPAH)
C1969363 BXGD016773 Middle age onset
C4024737 BXGD021397 Aplasia/Hypoplasia of the skin
C4551705 BXGD023397 Abnormality of chromosome stability
C4553962 BXGD023553 Hyperkeratosis, CTCAE
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0037687 (4S)-2-methylpentane-2,4-diol 118.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein