Showing entry for Neuronal acetylcholine receptor subunit alpha-2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013602
Protein NameNeuronal acetylcholine receptor subunit alpha-2
Uniport IdQ15822
GeneCHRNA2
Gene Id1135
DomainNeur_chan_LBD; Neur_chan_memb
Pfam PF02931   PF02932  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0034220 ion transmembrane transport
Biological Process GO:0006811 ion transport
Biological Process GO:0050877 nervous system process
Biological Process GO:0042391 regulation of membrane potential
Biological Process GO:0035094 response to nicotine
Biological Process GO:0007165 signal transduction
Biological Process GO:0007271 synaptic transmission, cholinergic
molecular function GO:0042166 acetylcholine binding
molecular function GO:0022848 acetylcholine-gated cation-selective channel activity
molecular function GO:0015464 acetylcholine receptor activity
molecular function GO:0008144 drug binding
molecular function GO:0030594 neurotransmitter receptor activity
molecular function GO:0044877 protein-containing complex binding
cellular component GO:0005892 acetylcholine-gated channel complex
cellular component GO:0016021 integral component of membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0043005 neuron projection
cellular component GO:0005886 plasma membrane
cellular component GO:0045211 postsynaptic membrane
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-181431 Acetylcholine binding and downstream events
R-HSA-622323 Presynaptic nicotinic acetylcholine receptors
R-HSA-622327 Postsynaptic nicotinic acetylcholine receptors
R-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
R-HSA-629597 Highly calcium permeable nicotinic acetylcholine receptors
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0006012 BXGD000360 Borderline Personality Disorder Mental Disorders
C0006287 BXGD000390 Bronchopulmonary Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0009676 BXGD000619 Confusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0028043 BXGD002066 Nicotine Dependence Chemically-Induced Disorders; Mental Disorders
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036973 BXGD002647 Shivering
C0085541 BXGD003180 Epilepsy, Frontal Lobe Nervous System Diseases
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0853193 BXGD010968 Bipolar I disorder Mental Disorders
C1510472 BXGD013170 Drug Dependence Chemically-Induced Disorders; Mental Disorders
C1835905 BXGD014066 Epilepsy, Nocturnal Frontal Lobe, Type 4 Nervous System Diseases; Mental Disorders
C3160814 BXGD018477 Cannabis use
C3696898 BXGD019348 Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Nervous System Diseases
C4692954 BXGD023592 SEIZURES, BENIGN FAMILIAL INFANTILE, 6
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000434 Ethanol 46.07
BXGC0000982 L-Homocysteine 135.19
BXGC0002796 Nicotine 162.23
BXGC0005874 Racemethionine 149.21
BXGC0006183 L-Cystine 240.3
BXGC0042462 Cysteine 121.02
BXGC0042510 Fluoxetine 309.13
BXGC0046653 (+/-)Nicotine 162.12
BXGC0050754 Cytisine 190.11
BXGC0052646 Tubocurarine 609.3
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein