Showing entry for Glutamate receptor ionotropic, kainate 5


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013630
Protein NameGlutamate receptor ionotropic, kainate 5
Uniport IdQ16478
GeneGRIK5
Gene Id2901
DomainANF_receptor; Lig_chan; Lig_chan-Glu_bd
Pfam PF01094   PF00060   PF10613  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.6 Nervous system hsa04724 Glutamatergic synapse
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0071333 cellular response to glucose stimulus
Biological Process GO:0051649 establishment of localization in cell
Biological Process GO:0060079 excitatory postsynaptic potential
Biological Process GO:0050804 modulation of chemical synaptic transmission
Biological Process GO:0043525 positive regulation of neuron apoptotic process
Biological Process GO:0006621 protein retention in ER lumen
Biological Process GO:0043113 receptor clustering
Biological Process GO:0031630 regulation of synaptic vesicle fusion to presynaptic active zone membrane
Biological Process GO:0035249 synaptic transmission, glutamatergic
molecular function GO:0008066 glutamate receptor activity
molecular function GO:0042802 identical protein binding
molecular function GO:0015277 kainate selective glutamate receptor activity
molecular function GO:0015276 ligand-gated ion channel activity
molecular function GO:0030165 PDZ domain binding
molecular function GO:0017124 SH3 domain binding
molecular function GO:0038023 signaling receptor activity
molecular function GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
cellular component GO:0030425 dendrite
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0098686 hippocampal mossy fiber to CA3 synapse
cellular component GO:0099056 integral component of presynaptic membrane
cellular component GO:0032983 kainate selective glutamate receptor complex
cellular component GO:0005654 nucleoplasm
cellular component GO:0043204 perikaryon
cellular component GO:0005886 plasma membrane
cellular component GO:0014069 postsynaptic density
cellular component GO:0045211 postsynaptic membrane
cellular component GO:0043195 terminal bouton
Reactome
Pathway Id Pathway Name
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-451306 Ionotropic activity of kainate receptors
R-HSA-451308 Activation of Ca-permeable Kainate Receptor
R-HSA-451326 Activation of kainate receptors upon glutamate binding
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0014556 BXGD000932 Epilepsy, Temporal Lobe Nervous System Diseases
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0035126 BXGD002509 Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0270824 BXGD006113 Visual seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006162 L-Glutamic acid 147.13
BXGC0025199 (S)-Willardiine 199.06
BXGC0036476 D-Glutamate 147.05
BXGC0049516 Kainic Acid 213.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein