Showing entry for Gamma-interferon-inducible protein 16


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013654
Protein NameGamma-interferon-inducible protein 16
Uniport IdQ16666
GeneIFI16
Gene Id3428
DomainHIN; PYRIN
Pfam PF02760   PF02758  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04621 NOD-like receptor signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0097202 activation of cysteine-type endopeptidase activity
Biological Process GO:0002218 activation of innate immune response
Biological Process GO:0006914 autophagy
Biological Process GO:0042149 cellular response to glucose starvation
Biological Process GO:0035458 cellular response to interferon-beta
Biological Process GO:0071479 cellular response to ionizing radiation
Biological Process GO:0051607 defense response to virus
Biological Process GO:0006954 inflammatory response
Biological Process GO:0045087 innate immune response
Biological Process GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
Biological Process GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Biological Process GO:0030224 monocyte differentiation
Biological Process GO:0030099 myeloid cell differentiation
Biological Process GO:2000117 negative regulation of cysteine-type endopeptidase activity
Biological Process GO:0043392 negative regulation of DNA binding
Biological Process GO:0045824 negative regulation of innate immune response
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0045071 negative regulation of viral genome replication
Biological Process GO:0001819 positive regulation of cytokine production
Biological Process GO:0032731 positive regulation of interleukin-1 beta production
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0032481 positive regulation of type I interferon production
Biological Process GO:0010506 regulation of autophagy
Biological Process GO:0040029 regulation of gene expression, epigenetic
molecular function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
molecular function GO:0003690 double-stranded DNA binding
molecular function GO:0042802 identical protein binding
molecular function GO:0003723 RNA binding
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
molecular function GO:0008134 transcription factor binding
cellular component GO:0005829 cytosol
cellular component GO:0016020 membrane
cellular component GO:0016607 nuclear speck
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-1834941 STING mediated induction of host immune responses
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA
R-HSA-3270619 IRF3-mediated induction of type I IFN
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003723 BXGD000217 Arbovirus Infections Infections
C0003872 BXGD000235 Arthritis, Psoriatic Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004943 BXGD000297 Behcet Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0008055 BXGD000514 Chikungunya Fever Infections
C0008479 BXGD000544 Chondrosarcoma Neoplasms
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0010823 BXGD000690 Cytomegalovirus Infections Infections
C0011644 BXGD000744 Scleroderma Skin and Connective Tissue Diseases
C0014060 BXGD000882 Encephalitis, St. Louis Infections; Nervous System Diseases
C0017086 BXGD001091 Gangrene Pathological Conditions, Signs and Symptoms
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019342 BXGD001322 Genital Herpes Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0019348 BXGD001325 Herpes Simplex Infections Infections; Skin and Connective Tissue Diseases
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0020097 BXGD001360 HTLV-I Infections Infections; Immune System Diseases
C0021053 BXGD001476 Immune System Diseases Immune System Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0023524 BXGD001681 Leukoencephalopathy, Progressive Multifocal Infections; Nervous System Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024131 BXGD001736 Lupus Vulgaris Infections; Skin and Connective Tissue Diseases
C0024138 BXGD001738 Lupus Erythematosus, Discoid Skin and Connective Tissue Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027708 BXGD002025 Nephroblastoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0031090 BXGD002280 Periodontal Diseases Stomatognathic Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0035369 BXGD002543 Retroviridae Infections Infections
C0036220 BXGD002587 Kaposi Sarcoma Neoplasms; Infections
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0037284 BXGD002679 Skin lesion Skin and Connective Tissue Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0042769 BXGD002999 Virus Diseases Infections
C0085253 BXGD003144 Adult-Onset Still Disease Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0151450 BXGD003420 Secondary Sjögren's syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C0151517 BXGD003431 Complete atrioventricular block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0162701 BXGD003978 Polysomnography
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206138 BXGD004158 CREST Syndrome Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases; Cardiovascular Diseases
C0262985 BXGD005277 Psoriasiform eczema Skin and Connective Tissue Diseases
C0263641 BXGD005337 Epithelial hyperplasia of skin Pathological Conditions, Signs and Symptoms
C0266929 BXGD005722 Chronic Periodontitis Stomatognathic Diseases
C0276199 BXGD006406 Canarypox (disorder)
C0276289 BXGD006418 Zika Virus Infection Infections
C0276609 BXGD006431 Acute type B viral hepatitis Digestive System Diseases; Infections
C0333516 BXGD006957 Tumor necrosis Pathological Conditions, Signs and Symptoms
C0343641 BXGD007636 Human papilloma virus infection Infections
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0409974 BXGD008401 Lupus Erythematosus Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Immune System Diseases
C0524587 BXGD009232 Mean Corpuscular Volume (result)
C0524909 BXGD009247 Hepatitis B, Chronic Digestive System Diseases; Infections
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0796154 BXGD010805 SIMPSON-GOLABI-BEHMEL SYNDROME, TYPE 1 Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases; Mental Disorders; Behavior and Behavior Mechanisms; Cardiovascular Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1258104 BXGD011823 Diffuse Scleroderma Skin and Connective Tissue Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1527336 BXGD013271 Sjogren's Syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2363741 BXGD017100 HIV-1 infection
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C2985280 BXGD018223 Blood Protein Measurement
C3714514 BXGD019409 Infection Infections
C3850141 BXGD019810 Acute-On-Chronic Liver Failure Digestive System Diseases
C4048329 BXGD021904 Immunosuppression
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
BXGC0006368 Formic acid 46.03
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein