Showing entry for Receptor-type tyrosine-protein phosphatase-like N


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013680
Protein NameReceptor-type tyrosine-protein phosphatase-like N
Uniport IdQ16849
GenePTPRN
Gene Id5798
DomainReceptor_IA-2; RESP18; Y_phosphatase
Pfam PF11548   PF14948   PF00102  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04940 Type I diabetes mellitus
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0019221 cytokine-mediated signaling pathway
Biological Process GO:1990502 dense core granule maturation
Biological Process GO:0030073 insulin secretion
Biological Process GO:0035773 insulin secretion involved in cellular response to glucose stimulus
Biological Process GO:0001553 luteinization
Biological Process GO:0035335 peptidyl-tyrosine dephosphorylation
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:1904692 positive regulation of type B pancreatic cell proliferation
Biological Process GO:0051591 response to cAMP
Biological Process GO:0043627 response to estrogen
Biological Process GO:0032868 response to insulin
Biological Process GO:0000302 response to reactive oxygen species
molecular function GO:0051020 GTPase binding
molecular function GO:0030507 spectrin binding
molecular function GO:0008134 transcription factor binding
molecular function GO:0044389 ubiquitin-like protein ligase binding
cellular component GO:0043679 axon terminus
cellular component GO:0005768 endosome
cellular component GO:0005794 Golgi apparatus
cellular component GO:0016021 integral component of membrane
cellular component GO:0043025 neuronal cell body
cellular component GO:0005634 nucleus
cellular component GO:0043204 perikaryon
cellular component GO:0005886 plasma membrane
cellular component GO:0030141 secretory granule
cellular component GO:0045202 synapse
cellular component GO:0030658 transport vesicle membrane
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0007095 BXGD000423 Carcinoid Tumor Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011880 BXGD000759 Diabetic Ketoacidosis Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014378 BXGD000912 Enterovirus Infections Infections
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0021670 BXGD001509 insulinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0085207 BXGD003140 Gestational Diabetes Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0205734 BXGD004115 Diabetes, Autoimmune Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0206161 BXGD004167 Reticulocyte count (procedure)
C0232197 BXGD004536 Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0342276 BXGD007449 Maturity onset diabetes mellitus in young Nutritional and Metabolic Diseases; Endocrine System Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C1305855 BXGD012348 Body mass index
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein