Showing entry for Leukotriene C4 synthase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013684
Protein NameLeukotriene C4 synthase
Uniport IdQ16873
GeneLTC4S
Gene Id4056
DomainMAPEG
Pfam PF01124  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00590 Arachidonic acid metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0019370 leukotriene biosynthetic process
Biological Process GO:0006691 leukotriene metabolic process
Biological Process GO:2001301 lipoxin biosynthetic process
Biological Process GO:0019372 lipoxygenase pathway
Biological Process GO:0042759 long-chain fatty acid biosynthetic process
molecular function GO:0008047 enzyme activator activity
molecular function GO:0004602 glutathione peroxidase activity
molecular function GO:0004364 glutathione transferase activity
molecular function GO:0042802 identical protein binding
molecular function GO:0004464 leukotriene-C4 synthase activity
molecular function GO:0008289 lipid binding
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0005635 nuclear envelope
cellular component GO:0031965 nuclear membrane
cellular component GO:0005640 nuclear outer membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-2142688 Synthesis of 5-eicosatetraenoic acids
R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-HSA-2142700 Synthesis of Lipoxins (LX)
R-HSA-2142753 Arachidonic acid metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-8978868 Fatty acid metabolism
R-HSA-9018677 Biosynthesis of DHA-derived SPMs
R-HSA-9018678 Biosynthesis of specialized proresolving mediators (SPMs)
R-HSA-9026395 Biosynthesis of DHA-derived sulfido conjugates
R-HSA-9026762 Biosynthesis of maresin conjugates in tissue regeneration (MCTR)
R-HSA-9026766 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002792 BXGD000129 anaphylaxis Immune System Diseases
C0004059 BXGD000250 aspirin intolerance
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004099 BXGD000253 Asthma, Exercise-Induced Respiratory Tract Diseases; Immune System Diseases
C0004135 BXGD000257 Ataxia Telangiectasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007787 BXGD000487 Transient Ischemic Attack Nervous System Diseases; Cardiovascular Diseases
C0007820 BXGD000491 Cerebrovascular Disorders Nervous System Diseases; Cardiovascular Diseases
C0007965 BXGD000508 Chediak-Higashi Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Immune System Diseases; Hemic and Lymphatic Diseases
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0013182 BXGD000803 Drug Allergy Immune System Diseases; Chemically-Induced Disorders
C0017658 BXGD001138 Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0018790 BXGD001221 Cardiac Arrest Cardiovascular Diseases
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027430 BXGD001988 Nasal Polyps Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0031117 BXGD002285 Peripheral Neuropathy Nervous System Diseases
C0035204 BXGD002511 Respiration Disorders Respiratory Tract Diseases
C0035242 BXGD002521 Respiratory Tract Diseases Respiratory Tract Diseases
C0037199 BXGD002671 Sinusitis Infections; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0042109 BXGD002957 Urticaria Skin and Connective Tissue Diseases; Immune System Diseases
C0085129 BXGD003128 Bronchial Hyperreactivity Respiratory Tract Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0155877 BXGD003830 Allergic asthma Respiratory Tract Diseases; Immune System Diseases
C0162557 BXGD003956 Liver Failure, Acute Digestive System Diseases
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0341106 BXGD007389 Eosinophilic esophagitis Digestive System Diseases; Immune System Diseases; Hemic and Lymphatic Diseases
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0543699 BXGD009293 ASA intolerant asthma Respiratory Tract Diseases; Immune System Diseases
C0557874 BXGD009444 Global developmental delay
C0578870 BXGD009553 Chronic idiopathic urticaria Skin and Connective Tissue Diseases; Immune System Diseases
C0600260 BXGD009701 Lung Diseases, Obstructive Respiratory Tract Diseases
C0741250 BXGD010028 aspirin sensitivity
C0856716 BXGD011107 Asthma aspirin-sensitive Respiratory Tract Diseases; Immune System Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1319853 BXGD012418 Asthma, Aspirin-Induced Respiratory Tract Diseases; Immune System Diseases; Chemically-Induced Disorders
C1335029 BXGD012754 Non-Neoplastic Peripheral Nervous System Disorder Nervous System Diseases
C1827849 BXGD013780 IgE-mediated allergic asthma Immune System Diseases
C1858430 BXGD015792 Death in infancy
C1861172 BXGD016016 Venous Thromboembolism Cardiovascular Diseases
C1867873 BXGD016473 Failure to thrive in infancy
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2607914 BXGD017148 Allergic rhinitis (disorder) Respiratory Tract Diseases; Immune System Diseases; Otorhinolaryngologic Diseases
C3203537 BXGD018565 Chronic hyperplastic eosinophilic sinusitis
C3279662 BXGD018768 Leukotriene C4 Synthase Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000989 Glutathione 307.32
BXGC0002825 Hexadecenoic acid 254.41
BXGC0005513 Hexadecanoic acid 256.42
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein