protein

Showing entry for Toll-like receptor 9

General Target Information
BXGT Id	BXGT013987
Protein Name	Toll-like receptor 9
Uniport Id	Q2EEY0
Gene	TLR9
Gene Id	100009693
Domain	LRR_12; LRR_6; LRR_8; TIR
Pfam	PF18837 PF13516 PF13855 PF01582
Organism	Equus caballus (Horse)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0002218	activation of innate immune response
Biological Process	GO:1902350	cellular response to chloroquine
Biological Process	GO:0051607	defense response to virus
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling
Biological Process	GO:0006955	immune response
Biological Process	GO:0006954	inflammatory response
Biological Process	GO:0045087	innate immune response
Biological Process	GO:0030277	maintenance of gastrointestinal epithelium
Biological Process	GO:0002755	MyD88-dependent toll-like receptor signaling pathway
Biological Process	GO:0032715	negative regulation of interleukin-6 production
Biological Process	GO:0050871	positive regulation of B cell activation
Biological Process	GO:0030890	positive regulation of B cell proliferation
Biological Process	GO:0002639	positive regulation of immunoglobulin production
Biological Process	GO:0050729	positive regulation of inflammatory response
Biological Process	GO:0032727	positive regulation of interferon-alpha production
Biological Process	GO:0032728	positive regulation of interferon-beta production
Biological Process	GO:0032729	positive regulation of interferon-gamma production
Biological Process	GO:0032733	positive regulation of interleukin-10 production
Biological Process	GO:0032735	positive regulation of interleukin-12 production
Biological Process	GO:0032741	positive regulation of interleukin-18 production
Biological Process	GO:0032755	positive regulation of interleukin-6 production
Biological Process	GO:0032757	positive regulation of interleukin-8 production
Biological Process	GO:0043410	positive regulation of MAPK cascade
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process
Biological Process	GO:0034165	positive regulation of toll-like receptor 9 signaling pathway
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production
Biological Process	GO:0045577	regulation of B cell differentiation
Biological Process	GO:0050707	regulation of cytokine secretion
Biological Process	GO:0002730	regulation of dendritic cell cytokine production
Biological Process	GO:0002237	response to molecule of bacterial origin
Biological Process	GO:0034162	toll-like receptor 9 signaling pathway
Biological Process	GO:0002224	toll-like receptor signaling pathway
Biological Process	GO:0032640	tumor necrosis factor production
molecular function	GO:0042802	identical protein binding
molecular function	GO:0038187	pattern recognition receptor activity
molecular function	GO:0042803	protein homodimerization activity
molecular function	GO:0035197	siRNA binding
molecular function	GO:0004888	transmembrane signaling receptor activity
molecular function	GO:0045322	unmethylated CpG binding
cellular component	GO:0005737	cytoplasm
cellular component	GO:0032009	early phagosome
cellular component	GO:0036019	endolysosome
cellular component	GO:0005789	endoplasmic reticulum membrane
cellular component	GO:0016021	integral component of membrane
cellular component	GO:0005764	lysosome
cellular component	GO:0005634	nucleus
cellular component	GO:0045335	phagocytic vesicle
cellular component	GO:0005886	plasma membrane

Reactome

Pathway Id	Pathway Name

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0000436	Glycerol		92.09
BXGC0002588	Magnesium		24.31

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}