protein

Showing entry for E3 ubiquitin-protein ligase CBL-B

General Target Information
BXGT Id	BXGT014523
Protein Name	E3 ubiquitin-protein ligase CBL-B
Uniport Id	Q3TTA7
Gene	Cblb
Gene Id	208650
Domain	Cbl_N; Cbl_N2; Cbl_N3; Prok-RING_4
Pfam	PF02262 PF02761 PF02762
Organism	Mus musculus (Mouse)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0006955	immune response
Biological Process	GO:0035556	intracellular signal transduction
Biological Process	GO:0046642	negative regulation of alpha-beta T cell proliferation
Biological Process	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity
Biological Process	GO:0050860	negative regulation of T cell receptor signaling pathway
Biological Process	GO:0018193	peptidyl-amino acid modification
Biological Process	GO:0045732	positive regulation of protein catabolic process
Biological Process	GO:0031398	positive regulation of protein ubiquitination
Biological Process	GO:0002669	positive regulation of T cell anergy
Biological Process	GO:0030155	regulation of cell adhesion
Biological Process	GO:0043087	regulation of GTPase activity
Biological Process	GO:2000583	regulation of platelet-derived growth factor receptor-alpha signaling pathway
Biological Process	GO:0043393	regulation of protein binding
Biological Process	GO:0050856	regulation of T cell receptor signaling pathway
Biological Process	GO:0007165	signal transduction
Biological Process	GO:0042110	T cell activation
Biological Process	GO:0050852	T cell receptor signaling pathway
molecular function	GO:0005509	calcium ion binding
molecular function	GO:0001784	phosphotyrosine residue binding
molecular function	GO:0019901	protein kinase binding
molecular function	GO:0030971	receptor tyrosine kinase binding
molecular function	GO:0017124	SH3 domain binding
molecular function	GO:0061630	ubiquitin protein ligase activity
cellular component	GO:0005829	cytosol
cellular component	GO:0045121	membrane raft
cellular component	GO:0005654	nucleoplasm
cellular component	GO:0005886	plasma membrane

Reactome

Pathway Id	Pathway Name

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0002586	Calcium		40.08
BXGC0003705	Chloride		35.45

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}