Showing entry for Obscurin


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT015886
Protein NameObscurin
Uniport IdQ5VST9
GeneOBSCN
Gene Id84033
Domainfn3; I-set; IQ; Pkinase; RhoGEF
Pfam PF00041   PF07679   PF00612   PF00069   PF00621  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0007275 multicellular organism development
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0036309 protein localization to M-band
Biological Process GO:0051056 regulation of small GTPase mediated signal transduction
Biological Process GO:0045214 sarcomere organization
molecular function GO:0030506 ankyrin binding
molecular function GO:0005524 ATP binding
molecular function GO:0005516 calmodulin binding
molecular function GO:0005085 guanyl-nucleotide exchange factor activity
molecular function GO:0046872 metal ion binding
molecular function GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
molecular function GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
molecular function GO:0032266 phosphatidylinositol-3-phosphate binding
molecular function GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
molecular function GO:0070273 phosphatidylinositol-4-phosphate binding
molecular function GO:0010314 phosphatidylinositol-5-phosphate binding
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:0008307 structural constituent of muscle
molecular function GO:0031432 titin binding
cellular component GO:0005829 cytosol
cellular component GO:0031430 M band
cellular component GO:0030016 myofibril
cellular component GO:0016604 nuclear body
cellular component GO:0005886 plasma membrane
cellular component GO:0042383 sarcolemma
cellular component GO:0030018 Z disc
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-193648 NRAGE signals death through JNK
R-HSA-193704 p75 NTR receptor-mediated signalling
R-HSA-194315 Signaling by Rho GTPases
R-HSA-194840 Rho GTPase cycle
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-73887 Death Receptor Signalling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007193 BXGD000451 Cardiomyopathy, Dilated Cardiovascular Diseases
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0016052 BXGD001040 Fibromuscular Dysplasia Cardiovascular Diseases
C0017654 BXGD001136 Glomerular Filtration Rate
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0023269 BXGD001627 leiomyosarcoma Neoplasms
C0026654 BXGD001914 Moyamoya Disease Nervous System Diseases; Cardiovascular Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0026850 BXGD001942 Muscular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0036202 BXGD002581 Sarcoidosis Hemic and Lymphatic Diseases
C0238198 BXGD004893 Gastrointestinal Stromal Tumors Digestive System Diseases; Neoplasms
C0349588 BXGD007933 Short stature
C0349788 BXGD007956 Arrhythmogenic Right Ventricular Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0429087 BXGD008647 Electrocardiogram: P-R interval
C0751336 BXGD010392 Distal Muscular Dystrophies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C2931384 BXGD018014 Moyamoya disease 1 Nervous System Diseases; Cardiovascular Diseases
C3853540 BXGD019820 Aspirin exacerbated respiratory disease Pathological Conditions, Signs and Symptoms; Infections; Respiratory Tract Diseases; Immune System Diseases; Chemically-Induced Disorders; Otorhinolaryngologic Diseases
C4551472 BXGD023303 Hypertrophic obstructive cardiomyopathy Cardiovascular Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein