Showing entry for Ubiquitin thioesterase OTU1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT015888
Protein NameUbiquitin thioesterase OTU1
Uniport IdQ5VVQ6
GeneYOD1
Gene Id55432
DomainOTU
Pfam PF02338  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa04141 Protein processing in endoplasmic reticulum
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030968 endoplasmic reticulum unfolded protein response
Biological Process GO:0016236 macroautophagy
Biological Process GO:1904153 negative regulation of retrograde protein transport, ER to cytosol
Biological Process GO:0016579 protein deubiquitination
Biological Process GO:0035871 protein K11-linked deubiquitination
Biological Process GO:1990167 protein K27-linked deubiquitination
Biological Process GO:0035523 protein K29-linked deubiquitination
Biological Process GO:1990168 protein K33-linked deubiquitination
Biological Process GO:0071108 protein K48-linked deubiquitination
Biological Process GO:0070536 protein K63-linked deubiquitination
Biological Process GO:0030433 ubiquitin-dependent ERAD pathway
molecular function GO:1990380 Lys48-specific deubiquitinase activity
molecular function GO:0061578 Lys63-specific deubiquitinase activity
molecular function GO:0046872 metal ion binding
molecular function GO:0004843 thiol-dependent ubiquitin-specific protease activity
molecular function GO:0031625 ubiquitin protein ligase binding
molecular function GO:0101005 ubiquitinyl hydrolase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
Reactome
Pathway Id Pathway Name
R-HSA-392499 Metabolism of proteins
R-HSA-5688426 Deubiquitination
R-HSA-5689896 Ovarian tumor domain proteases
R-HSA-597592 Post-translational protein modification
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0005890 BXGD000345 Body Height
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031099 BXGD002282 Periodontitis Stomatognathic Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0428883 BXGD008639 Diastolic blood pressure
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0596887 BXGD009648 mathematical ability
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002588 Magnesium 24.31
BXGC0002722 Nitrate 62
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein