protein

Showing entry for Inhibitor of nuclear factor kappa-B kinase subunit alpha

General Target Information
BXGT Id	BXGT015995
Protein Name	Inhibitor of nuclear factor kappa-B kinase subunit alpha
Uniport Id	Q60680
Gene	Chuk
Gene Id
Domain	IKBKB_SDD; IKKbetaNEMObind; Pkinase
Pfam	PF18397 PF12179 PF00069
Organism	Mus musculus (Mouse)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0071276	cellular response to cadmium ion
Biological Process	GO:0034614	cellular response to reactive oxygen species
Biological Process	GO:0071356	cellular response to tumor necrosis factor
Biological Process	GO:0098586	cellular response to virus
Biological Process	GO:0051607	defense response to virus
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling
Biological Process	GO:0007252	I-kappaB phosphorylation
Biological Process	GO:0007595	lactation
Biological Process	GO:0060749	mammary gland alveolus development
Biological Process	GO:0033598	mammary gland epithelial cell proliferation
Biological Process	GO:0002011	morphogenesis of an epithelial sheet
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity
Biological Process	GO:0038061	NIK/NF-kappaB signaling
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth
Biological Process	GO:0030316	osteoclast differentiation
Biological Process	GO:0018105	peptidyl-serine phosphorylation
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process	GO:0032727	positive regulation of interferon-alpha production
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity
Biological Process	GO:0045893	positive regulation of transcription, DNA-templated
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0006468	protein phosphorylation
Biological Process	GO:0061847	response to cholecystokinin
Biological Process	GO:0032496	response to lipopolysaccharide
Biological Process	GO:0035994	response to muscle stretch
Biological Process	GO:0010033	response to organic substance
Biological Process	GO:0007266	Rho protein signal transduction
Biological Process	GO:0051146	striated muscle cell differentiation
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway
molecular function	GO:0005524	ATP binding
molecular function	GO:0008384	IkappaB kinase activity
molecular function	GO:0044877	protein-containing complex binding
molecular function	GO:0046982	protein heterodimerization activity
molecular function	GO:0042803	protein homodimerization activity
molecular function	GO:0004672	protein kinase activity
molecular function	GO:0004674	protein serine/threonine kinase activity
molecular function	GO:0097110	scaffold protein binding
molecular function	GO:1990459	transferrin receptor binding
cellular component	GO:0035631	CD40 receptor complex
cellular component	GO:0005737	cytoplasm
cellular component	GO:0009898	cytoplasmic side of plasma membrane
cellular component	GO:0005829	cytosol
cellular component	GO:0008385	IkappaB kinase complex
cellular component	GO:0043231	intracellular membrane-bounded organelle
cellular component	GO:0005654	nucleoplasm

Reactome

Pathway Id	Pathway Name

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0040364	Artesunate		384.18

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}