Showing entry for Deoxynucleoside triphosphate triphosphohydrolase SAMHD1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT015996
Protein NameDeoxynucleoside triphosphate triphosphohydrolase SAMHD1
Uniport IdQ60710
GeneSamhd1
Gene Id56045
DomainHD; SAM_2
Pfam PF01966   PF07647  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006974 cellular response to DNA damage stimulus
Biological Process GO:0046061 dATP catabolic process
Biological Process GO:0051607 defense response to virus
Biological Process GO:0009264 deoxyribonucleotide catabolic process
Biological Process GO:0006203 dGTP catabolic process
Biological Process GO:0110025 DNA strand resection involved in replication fork processing
Biological Process GO:0000724 double-strand break repair via homologous recombination
Biological Process GO:0045087 innate immune response
Biological Process GO:0060339 negative regulation of type I interferon-mediated signaling pathway
Biological Process GO:0051289 protein homotetramerization
Biological Process GO:0045088 regulation of innate immune response
Biological Process GO:0016446 somatic hypermutation of immunoglobulin genes
molecular function GO:0008832 dGTPase activity
molecular function GO:0032567 dGTP binding
molecular function GO:0005525 GTP binding
molecular function GO:0042802 identical protein binding
molecular function GO:0003676 nucleic acid binding
molecular function GO:0004540 ribonuclease activity
molecular function GO:0003723 RNA binding
molecular function GO:0003697 single-stranded DNA binding
molecular function GO:0016793 triphosphoric monoester hydrolase activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0035861 site of double-strand break
cellular component GO:0097197 tetraspanin-enriched microdomain
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein