Showing entry for Krueppel-like factor 4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT015999
Protein NameKrueppel-like factor 4
Uniport IdQ60793
GeneKlf4
Gene Id16600
Domainzf-C2H2
Pfam PF00096  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0060070 canonical Wnt signaling pathway
Biological Process GO:0030154 cell differentiation
Biological Process GO:0071409 cellular response to cycloheximide
Biological Process GO:0071363 cellular response to growth factor stimulus
Biological Process GO:0070301 cellular response to hydrogen peroxide
Biological Process GO:0071499 cellular response to laminar fluid shear stress
Biological Process GO:1990830 cellular response to leukemia inhibitory factor
Biological Process GO:1901653 cellular response to peptide
Biological Process GO:0071300 cellular response to retinoic acid
Biological Process GO:0009913 epidermal cell differentiation
Biological Process GO:0048730 epidermis morphogenesis
Biological Process GO:0045444 fat cell differentiation
Biological Process GO:0016525 negative regulation of angiogenesis
Biological Process GO:0030336 negative regulation of cell migration
Biological Process GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production
Biological Process GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process GO:0043433 negative regulation of DNA-binding transcription factor activity
Biological Process GO:0070373 negative regulation of ERK1 and ERK2 cascade
Biological Process GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0034115 negative regulation of heterotypic cell-cell adhesion
Biological Process GO:0032717 negative regulation of interleukin-8 production
Biological Process GO:1904998 negative regulation of leukocyte adhesion to arterial endothelial cell
Biological Process GO:0014740 negative regulation of muscle hyperplasia
Biological Process GO:0032088 negative regulation of NF-kappaB transcription factor activity
Biological Process GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
Biological Process GO:0051898 negative regulation of protein kinase B signaling
Biological Process GO:0060761 negative regulation of response to cytokine stimulus
Biological Process GO:0048662 negative regulation of smooth muscle cell proliferation
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0032270 positive regulation of cellular protein metabolic process
Biological Process GO:1904798 positive regulation of core promoter binding
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0046985 positive regulation of hemoglobin biosynthetic process
Biological Process GO:0045429 positive regulation of nitric oxide biosynthetic process
Biological Process GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
Biological Process GO:0051247 positive regulation of protein metabolic process
Biological Process GO:1903672 positive regulation of sprouting angiogenesis
Biological Process GO:0051973 positive regulation of telomerase activity
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0031077 post-embryonic camera-type eye development
Biological Process GO:0035166 post-embryonic hemopoiesis
Biological Process GO:0048679 regulation of axon regeneration
Biological Process GO:0120222 regulation of blastocyst development
Biological Process GO:0045595 regulation of cell differentiation
Biological Process GO:0042127 regulation of cell population proliferation
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0010033 response to organic substance
Biological Process GO:0032526 response to retinoic acid
Biological Process GO:0019827 stem cell population maintenance
Biological Process GO:0006351 transcription, DNA-templated
molecular function GO:0008013 beta-catenin binding
molecular function GO:0000987 cis-regulatory region sequence-specific DNA binding
molecular function GO:0003677 DNA binding
molecular function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
molecular function GO:0003700 DNA-binding transcription factor activity
molecular function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
molecular function GO:0003690 double-stranded DNA binding
molecular function GO:0042826 histone deacetylase binding
molecular function GO:0046872 metal ion binding
molecular function GO:0035014 phosphatidylinositol 3-kinase regulator activity
molecular function GO:1990841 promoter-specific chromatin binding
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
molecular function GO:0001010 RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity
molecular function GO:0001085 RNA polymerase II transcription factor binding
molecular function GO:0043565 sequence-specific DNA binding
molecular function GO:1990837 sequence-specific double-stranded DNA binding
molecular function GO:0001221 transcription cofactor binding
molecular function GO:0008134 transcription factor binding
molecular function GO:0000976 transcription regulatory region sequence-specific DNA binding
cellular component GO:0000785 chromatin
cellular component GO:0005737 cytoplasm
cellular component GO:0000790 nuclear chromatin
cellular component GO:0005719 nuclear euchromatin
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005667 transcription regulator complex
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein