Showing entry for Rho-associated protein kinase 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT016047
Protein NameRho-associated protein kinase 2
Uniport IdQ62868
GeneRock2
Gene Id25537
DomainPkinase; Rho_Binding
Pfam PF00069   PF08912  
OrganismRattus norvegicus (Rat)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0031032 actomyosin structure organization
Biological Process GO:1905145 cellular response to acetylcholine
Biological Process GO:0071394 cellular response to testosterone stimulus
Biological Process GO:0051298 centrosome duplication
Biological Process GO:0030261 chromosome condensation
Biological Process GO:0030866 cortical actin cytoskeleton organization
Biological Process GO:0048813 dendrite morphogenesis
Biological Process GO:0048598 embryonic morphogenesis
Biological Process GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
Biological Process GO:0007249 I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0000281 mitotic cytokinesis
Biological Process GO:0061157 mRNA destabilization
Biological Process GO:0016525 negative regulation of angiogenesis
Biological Process GO:1903347 negative regulation of bicellular tight junction assembly
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0035509 negative regulation of myosin-light-chain-phosphatase activity
Biological Process GO:0045019 negative regulation of nitric oxide biosynthetic process
Biological Process GO:0150033 negative regulation of protein localization to lysosome
Biological Process GO:0001843 neural tube closure
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0018107 peptidyl-threonine phosphorylation
Biological Process GO:1902004 positive regulation of amyloid-beta formation
Biological Process GO:1902993 positive regulation of amyloid precursor protein catabolic process
Biological Process GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
Biological Process GO:0010613 positive regulation of cardiac muscle hypertrophy
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:0010825 positive regulation of centrosome duplication
Biological Process GO:0032723 positive regulation of connective tissue growth factor production
Biological Process GO:1905205 positive regulation of connective tissue replacement
Biological Process GO:0010595 positive regulation of endothelial cell migration
Biological Process GO:0090271 positive regulation of fibroblast growth factor production
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0043410 positive regulation of MAPK cascade
Biological Process GO:1902966 positive regulation of protein localization to early endosome
Biological Process GO:0001934 positive regulation of protein phosphorylation
Biological Process GO:0051496 positive regulation of stress fiber assembly
Biological Process GO:0098974 postsynaptic actin cytoskeleton organization
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0110061 regulation of angiotensin-activated signaling pathway
Biological Process GO:0097746 regulation of blood vessel diameter
Biological Process GO:1901888 regulation of cell junction assembly
Biological Process GO:1900037 regulation of cellular response to hypoxia
Biological Process GO:0042752 regulation of circadian rhythm
Biological Process GO:1903140 regulation of establishment of endothelial barrier
Biological Process GO:0045616 regulation of keratinocyte differentiation
Biological Process GO:0031644 regulation of nervous system process
Biological Process GO:0051246 regulation of protein metabolic process
Biological Process GO:1990776 response to angiotensin
Biological Process GO:0002931 response to ischemia
Biological Process GO:0071559 response to transforming growth factor beta
Biological Process GO:0007266 Rho protein signal transduction
Biological Process GO:0048511 rhythmic process
Biological Process GO:0006939 smooth muscle contraction
Biological Process GO:0039694 viral RNA genome replication
molecular function GO:0005524 ATP binding
molecular function GO:0017049 GTP-Rho binding
molecular function GO:0016301 kinase activity
molecular function GO:0046872 metal ion binding
molecular function GO:0004672 protein kinase activity
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:0072518 Rho-dependent protein serine/threonine kinase activity
cellular component GO:0005813 centrosome
cellular component GO:0005737 cytoplasm
cellular component GO:0036464 cytoplasmic ribonucleoprotein granule
cellular component GO:0005856 cytoskeleton
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0098685 Schaffer collateral - CA1 synapse
cellular component GO:0031616 spindle pole centrosome
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0005683 Quercetin 302.24
BXGC0034256 Rottlerin 516.18
BXGC0045254 Sb-202190 331.11
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein