Showing entry for Estrogen receptor beta


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT016053
Protein NameEstrogen receptor beta
Uniport IdQ62986
GeneEsr2
Gene Id25149
DomainERbeta_N; Hormone_recep; zf-C4
Pfam PF12497   PF00104   PF00105  
OrganismRattus norvegicus (Rat)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0021764 amygdala development
Biological Process GO:0001662 behavioral fear response
Biological Process GO:0007420 brain development
Biological Process GO:0035690 cellular response to drug
Biological Process GO:0071392 cellular response to estradiol stimulus
Biological Process GO:0071259 cellular response to magnetism
Biological Process GO:0071407 cellular response to organic cyclic compound
Biological Process GO:0021549 cerebellum development
Biological Process GO:0060743 epithelial cell maturation involved in prostate gland development
Biological Process GO:0044849 estrous cycle
Biological Process GO:0008585 female gonad development
Biological Process GO:0008628 hormone-mediated apoptotic signaling pathway
Biological Process GO:0021854 hypothalamus development
Biological Process GO:0030520 intracellular estrogen receptor signaling pathway
Biological Process GO:0030518 intracellular steroid hormone receptor signaling pathway
Biological Process GO:0007611 learning or memory
Biological Process GO:0008584 male gonad development
Biological Process GO:0060766 negative regulation of androgen receptor signaling pathway
Biological Process GO:0048521 negative regulation of behavior
Biological Process GO:0060548 negative regulation of cell death
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0050680 negative regulation of epithelial cell proliferation
Biological Process GO:2000252 negative regulation of feeding behavior
Biological Process GO:1901215 negative regulation of neuron death
Biological Process GO:2000378 negative regulation of reactive oxygen species metabolic process
Biological Process GO:0048662 negative regulation of smooth muscle cell proliferation
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0001764 neuron migration
Biological Process GO:0001541 ovarian follicle development
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0097755 positive regulation of blood vessel diameter
Biological Process GO:0051091 positive regulation of DNA-binding transcription factor activity
Biological Process GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0030850 prostate gland development
Biological Process GO:0060740 prostate gland epithelium morphogenesis
Biological Process GO:0042127 regulation of cell population proliferation
Biological Process GO:0043523 regulation of neuron apoptotic process
Biological Process GO:0014823 response to activity
Biological Process GO:1903925 response to bisphenol A
Biological Process GO:0071548 response to dexamethasone
Biological Process GO:0042493 response to drug
Biological Process GO:0032355 response to estradiol
Biological Process GO:0043627 response to estrogen
Biological Process GO:0045471 response to ethanol
Biological Process GO:0033595 response to genistein
Biological Process GO:0009725 response to hormone
Biological Process GO:0044752 response to human chorionic gonadotropin
Biological Process GO:0017085 response to insecticide
Biological Process GO:0031667 response to nutrient levels
Biological Process GO:0014070 response to organic cyclic compound
Biological Process GO:1902074 response to salt
Biological Process GO:0033574 response to testosterone
Biological Process GO:0009414 response to water deprivation
Biological Process GO:0060009 Sertoli cell development
Biological Process GO:0060011 Sertoli cell proliferation
Biological Process GO:0060065 uterus development
Biological Process GO:0060068 vagina development
molecular function GO:0003677 DNA binding
molecular function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
molecular function GO:0008144 drug binding
molecular function GO:0019899 enzyme binding
molecular function GO:1903924 estradiol binding
molecular function GO:0030284 estrogen receptor activity
molecular function GO:0034056 estrogen response element binding
molecular function GO:0042562 hormone binding
molecular function GO:0042802 identical protein binding
molecular function GO:0004879 nuclear receptor activity
molecular function GO:0042975 peroxisome proliferator activated receptor binding
molecular function GO:1990841 promoter-specific chromatin binding
molecular function GO:0070491 repressing transcription factor binding
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
molecular function GO:0043565 sequence-specific DNA binding
molecular function GO:0005496 steroid binding
molecular function GO:1990239 steroid hormone binding
molecular function GO:0003707 steroid hormone receptor activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0005929 cilium
cellular component GO:0005737 cytoplasm
cellular component GO:0005739 mitochondrion
cellular component GO:0043025 neuronal cell body
cellular component GO:0043005 neuron projection
cellular component GO:0005634 nucleus
cellular component GO:0043204 perikaryon
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0005886 plasma membrane
cellular component GO:0032993 protein-DNA complex
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000130 Estradiol 272.38
BXGC0001325 Progesterone 314.46
BXGC0001899 Daidzein 254.24
BXGC0002627 17alpha-ethynylestradiol 296.4
BXGC0003707 Estrogen 268.36
BXGC0003773 Estriol 288.38
BXGC0005502 Coumestrol 268.22
BXGC0005624 Genistein 270.24
BXGC0006362 Estrone 270.37
BXGC0019164 Raloxifene 473.17
BXGC0020800 Testosterone 288.21
BXGC0049447 acetate 59.01
BXGC0051184 Calycosin 284.07
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein