Showing entry for [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT016122
Protein Name[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
Uniport IdQ64536
GenePdk2
Gene Id81530
DomainBCDHK_Adom3; HATPase_c
Pfam PF10436   PF02518  
OrganismRattus norvegicus (Rat)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0031670 cellular response to nutrient
Biological Process GO:0034614 cellular response to reactive oxygen species
Biological Process GO:0042593 glucose homeostasis
Biological Process GO:0006006 glucose metabolic process
Biological Process GO:0008286 insulin receptor signaling pathway
Biological Process GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
Biological Process GO:1904183 negative regulation of pyruvate dehydrogenase activity
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate
Biological Process GO:0050848 regulation of calcium-mediated signaling
Biological Process GO:0010565 regulation of cellular ketone metabolic process
Biological Process GO:0006111 regulation of gluconeogenesis
Biological Process GO:0010906 regulation of glucose metabolic process
Biological Process GO:0006885 regulation of pH
molecular function GO:0005524 ATP binding
molecular function GO:0042802 identical protein binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity
cellular component GO:0005967 mitochondrial pyruvate dehydrogenase complex
cellular component GO:0005739 mitochondrion
cellular component GO:0045254 pyruvate dehydrogenase complex
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0002591 Potassium 39.1
BXGC0013795 phenylglyoxylic acid 150.03
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein