Showing entry for DNA topoisomerase 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT017229
Protein NameDNA topoisomerase 1
Uniport IdQ7YR26
GeneTOP1
Gene Id
Domain-
Pfam PF14370   PF01028   PF02919  
OrganismChlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0032922 circadian regulation of gene expression
Biological Process GO:0006265 DNA topological change
molecular function GO:0003682 chromatin binding
molecular function GO:0003677 DNA binding
molecular function GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
cellular component GO:0005694 chromosome
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0016470 Camptothecin 348.11
BXGC0034783 Doxorubicin 543.17
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein