Showing entry for Neuroligin-4, X-linked


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT018492
Protein NameNeuroligin-4, X-linked
Uniport IdQ8N0W4
GeneNLGN4X
Gene Id57502
DomainCOesterase
Pfam PF00135  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04514 Cell adhesion molecules (CAMs)
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030534 adult behavior
Biological Process GO:0003360 brainstem development
Biological Process GO:0045216 cell-cell junction organization
Biological Process GO:0021549 cerebellum development
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0007612 learning
Biological Process GO:0050804 modulation of chemical synaptic transmission
Biological Process GO:0090394 negative regulation of excitatory postsynaptic potential
Biological Process GO:0007158 neuron cell-cell adhesion
Biological Process GO:0030182 neuron differentiation
Biological Process GO:0035265 organ growth
Biological Process GO:0097104 postsynaptic membrane assembly
Biological Process GO:0099054 presynapse assembly
Biological Process GO:0097105 presynaptic membrane assembly
Biological Process GO:0035176 social behavior
Biological Process GO:0050808 synapse organization
Biological Process GO:0048488 synaptic vesicle endocytosis
Biological Process GO:0071625 vocalization behavior
molecular function GO:0050839 cell adhesion molecule binding
molecular function GO:0031404 chloride ion binding
molecular function GO:0042043 neurexin family protein binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0097110 scaffold protein binding
molecular function GO:0038023 signaling receptor activity
cellular component GO:0098985 asymmetric, glutamatergic, excitatory synapse
cellular component GO:0009986 cell surface
cellular component GO:0030425 dendrite
cellular component GO:0060076 excitatory synapse
cellular component GO:0016021 integral component of membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0098839 postsynaptic density membrane
cellular component GO:0098793 presynapse
cellular component GO:0089717 spanning component of membrane
cellular component GO:0098983 symmetric, GABA-ergic, inhibitory synapse
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-112316 Neuronal System
R-HSA-112316 Neuronal System
R-HSA-6794361 Neurexins and neuroligins
R-HSA-6794361 Neurexins and neuroligins
R-HSA-6794362 Protein-protein interactions at synapses
R-HSA-6794362 Protein-protein interactions at synapses
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0004936 BXGD000295 Mental disorders Mental Disorders
C0006111 BXGD000369 Brain Diseases Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0020757 BXGD001466 Ichthyoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0020758 BXGD001467 Congenital ichthyosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0025362 BXGD001866 Mental Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026351 BXGD001900 Moderate intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0027651 BXGD002009 Neoplasms Neoplasms
C0030421 BXGD002218 Paraganglioma Neoplasms
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038271 BXGD002742 Stereotyped Behavior Behavior and Behavior Mechanisms
C0038273 BXGD002743 Stereotypic Movement Disorder Mental Disorders
C0040517 BXGD002872 Gilles de la Tourette syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0079588 BXGD003084 Ichthyosis, X-Linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0151611 BXGD003447 Electroencephalogram abnormal Nervous System Diseases
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0338986 BXGD007219 Atypical autism Mental Disorders
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0524528 BXGD009229 Pervasive Development Disorder Mental Disorders
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0751265 BXGD010370 Learning Disabilities Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0856975 BXGD011127 Autistic behavior Behavior and Behavior Mechanisms
C0877243 BXGD011344 Increased serum serotonin
C1136249 BXGD011715 Mental Retardation, X-Linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1837352 BXGD014223 Childhood onset
C1837649 BXGD014253 Impaired ability to form peer relationships Mental Disorders
C1837650 BXGD014254 Lack of spontaneous play Behavior and Behavior Mechanisms
C1837653 BXGD014255 Inflexible adherence to routines or rituals Behavior and Behavior Mechanisms
C1845334 BXGD014740 ASPERGER SYNDROME, X-LINKED, SUSCEPTIBILITY TO, 2 (finding)
C1845337 BXGD014742 Lack of peer relationships Mental Disorders
C1845539 BXGD014751 AUTISM, X-LINKED, SUSCEPTIBILITY TO, 2 (finding)
C1853237 BXGD015319 Isolated cases
C3501611 BXGD019023 Mental Retardation, X-Linked Nonsyndromic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4021798 BXGD020788 Impaired use of nonverbal behaviors Mental Disorders
C4021799 BXGD020789 Restrictive behavior
C4551683 BXGD023389 Adrenal Gland Pheochromocytoma Neoplasms; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein