Showing entry for Retinol dehydrogenase 11


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT018793
Protein NameRetinol dehydrogenase 11
Uniport IdQ8TC12
GeneRDH11
Gene Id51109
Domainadh_short
Pfam PF00106  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00830 Retinol metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0110095 cellular detoxification of aldehyde
Biological Process GO:0042574 retinal metabolic process
Biological Process GO:0001523 retinoid metabolic process
Biological Process GO:0042572 retinol metabolic process
molecular function GO:0052650 NADP-retinol dehydrogenase activity
molecular function GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
molecular function GO:0004745 retinol dehydrogenase activity
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0016021 integral component of membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-162582 Signal Transduction
R-HSA-196854 Metabolism of vitamins and cofactors
R-HSA-2187338 Visual phototransduction
R-HSA-2453902 The canonical retinoid cycle in rods (twilight vision)
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-418594 G alpha (i) signalling events
R-HSA-5362517 Signaling by Retinoic Acid
R-HSA-5365859 RA biosynthesis pathway
R-HSA-6806667 Metabolism of fat-soluble vitamins
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-975634 Retinoid metabolism and transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024636 BXGD001793 Malocclusion Stomatognathic Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0042842 BXGD003005 Vitamin A Deficiency Nutritional and Metabolic Diseases
C0278134 BXGD006498 Absence of sensation Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0349588 BXGD007933 Short stature
C0423109 BXGD008470 Upward slant of palpebral fissure
C0424230 BXGD008522 Motor retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0557874 BXGD009444 Global developmental delay
C0854723 BXGD011026 Retinal Dystrophies Eye Diseases
C0860439 BXGD011224 Mottled pigmentation Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0936223 BXGD011477 Metastatic Prostate Carcinoma Neoplasms; Male Urogenital Diseases
C1282496 BXGD012147 Metastasis from malignant tumor of prostate
C1844813 BXGD014679 Widely spaced teeth
C1858085 BXGD015770 Malar flattening
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2919142 BXGD017867 Short Stature, CTCAE
C4015242 BXGD020196 RETINAL DYSTROPHY, JUVENILE CATARACTS, AND SHORT STATURE SYNDROME
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0047568 Retinol 286.23
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein