Showing entry for Histone deacetylase 7


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT018992
Protein NameHistone deacetylase 7
Uniport IdQ8WUI4
GeneHDAC7
Gene Id51564
DomainHist_deacetyl
Pfam PF00850  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.5 Substance dependence hsa05034 Alcoholism
6. Human Diseases 6.1 Cancers: Overview hsa05203 Viral carcinogenesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007043 cell-cell junction assembly
Biological Process GO:0032703 negative regulation of interleukin-2 production
Biological Process GO:1901223 negative regulation of NIK/NF-kappaB signaling
Biological Process GO:0045668 negative regulation of osteoblast differentiation
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
Biological Process GO:0006476 protein deacetylation
Biological Process GO:0001570 vasculogenesis
molecular function GO:0071889 14-3-3 protein binding
molecular function GO:0033613 activating transcription factor binding
molecular function GO:0003682 chromatin binding
molecular function GO:0046872 metal ion binding
molecular function GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
molecular function GO:0033558 protein deacetylase activity
molecular function GO:0019901 protein kinase binding
molecular function GO:0005080 protein kinase C binding
molecular function GO:0070491 repressing transcription factor binding
molecular function GO:0003714 transcription corepressor activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0000118 histone deacetylase complex
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-157118 Signaling by NOTCH
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-1980143 Signaling by NOTCH1
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-212436 Generic Transcription Pathway
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer
R-HSA-2644603 Signaling by NOTCH1 in Cancer
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-2990846 SUMOylation
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
R-HSA-350054 Notch-HLH transcription pathway
R-HSA-392499 Metabolism of proteins
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-597592 Post-translational protein modification
R-HSA-6807070 PTEN Regulation
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-8943724 Regulation of PTEN gene transcription
R-HSA-9006925 Intracellular signaling by second messengers
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0005823 BXGD000339 Blood Pressure
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006413 BXGD000397 Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0008313 BXGD000528 Cholangitis, Sclerosing Digestive System Diseases
C0008479 BXGD000544 Chondrosarcoma Neoplasms
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030297 BXGD002204 Pancreatic Neoplasm Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0030848 BXGD002261 Peyronie Disease Skin and Connective Tissue Diseases; Male Urogenital Diseases
C0032181 BXGD002332 Platelet Count measurement
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0038013 BXGD002725 Ankylosing spondylitis Musculoskeletal Diseases
C0042345 BXGD002977 Varicosity Cardiovascular Diseases
C0079773 BXGD003100 Lymphoma, T-Cell, Cutaneous Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0200635 BXGD004041 Lymphocyte Count measurement
C0206139 BXGD004159 Lichen Planus, Oral Skin and Connective Tissue Diseases; Stomatognathic Diseases
C0206694 BXGD004245 Mucoepidermoid Carcinoma Neoplasms
C0206701 BXGD004251 Cystadenocarcinoma, Serous Neoplasms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0278764 BXGD006581 Adult Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0278879 BXGD006610 Childhood Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0281361 BXGD006774 Adenocarcinoma of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0409959 BXGD008400 Osteoarthritis, Knee Musculoskeletal Diseases
C0428883 BXGD008639 Diastolic blood pressure
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0566602 BXGD009489 Primary sclerosing cholangitis Digestive System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0730328 BXGD009959 Central Serous Chorioretinopathy Eye Diseases
C0741260 BXGD010029 Adult onset asthma
C0854248 BXGD011010 Pneumonia due to Gram negative bacteria Infections; Respiratory Tract Diseases
C0871470 BXGD011316 Systolic Pressure
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1261502 BXGD011856 Finding of Mean Corpuscular Hemoglobin
C1266025 BXGD011935 Traditional Serrated Adenoma Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1275278 BXGD012074 Extraskeletal Myxoid Chondrosarcoma Neoplasms
C1290884 BXGD012198 Inflammatory disorder Pathological Conditions, Signs and Symptoms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1510885 BXGD013178 Angiogenic Switch
C1527304 BXGD013266 Allergic Reaction Immune System Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C3149841 BXGD018287 POLYCYSTIC KIDNEY DISEASE 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000076 p-Coumaroyl tartaric acid glucosidic ester 150.09
BXGC0000099 3,4-Dihydroxyphenylacetic acid 168.15
BXGC0000504 Vanillic acid 168.15
BXGC0000528 Salicylic acid 138.12
BXGC0000539 Anthranilic acid 137.14
BXGC0000843 3-Methylbutanoic acid 102.13
BXGC0001273 Hippuric acid 179.17
BXGC0001380 Succinic acid 118.09
BXGC0001545 Harmine 212.25
BXGC0001857 Caffeic acid 180.16
BXGC0001860 Neochlorogenic acid 354.31
BXGC0001879 Chlorogenic acid 354.31
BXGC0001887 m-Coumaric acid 164.16
BXGC0001918 3,5-Di-O-caffeoylquinic acid 516.45
BXGC0002244 Doconexent 328.49
BXGC0002394 Pentanoic acid 102.13
BXGC0002427 2-Methylpropanoic acid 88.11
BXGC0002591 Potassium 39.1
BXGC0003205 (+)-Valine 117.15
BXGC0004269 Propanoic acid 74.08
BXGC0004588 trans-Cinnamic acid 148.16
BXGC0004647 3-(3,4-Dihydroxyphenyl)propanoic acid 182.17
BXGC0004665 4-Aminobutyric acid 103.12
BXGC0005624 Genistein 270.24
BXGC0005796 Butanoic acid 88.11
BXGC0005898 2,3-Dihydroxybenzoic acid 154.12
BXGC0005982 Curcumin 368.38
BXGC0006198 Citric acid 192.12
BXGC0006366 trans-Ferulic acid 194.18
BXGC0007028 beta-Thujaplicin 164.2
BXGC0013582 Curcumin 368.13
BXGC0013952 (2Z)-2-[(4-Chlorophenyl)Methylidene]-1-Benzofuran-3-One 256.03
BXGC0014602 Kojic Acid 142.03
BXGC0020680 Mandelic Acid 152.05
BXGC0023330 Methylconiferylaldehyde 192.08
BXGC0025617 Aureusidin 286.05
BXGC0026480 Osajin 404.16
BXGC0033112 Acetylcysteine 163.03
BXGC0034421 n.a 530.14
BXGC0034778 Artemisinin 282.15
BXGC0034783 Doxorubicin 543.17
BXGC0037070 Epicoccolide B 358.07
BXGC0037722 Pomiferin 420.16
BXGC0042127 Oxyquinoline 145.05
BXGC0042413 Calcitriol 416.33
BXGC0046518 Chloroquine 319.18
BXGC0047088 Ursolic Acid 456.36
BXGC0047529 2-hydroxybutyric acid 104.05
BXGC0047692 Gefitinib 446.15
BXGC0048689 Sorbic Acid 112.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein