Showing entry for Estradiol 17-beta-dehydrogenase 8


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019352
Protein NameEstradiol 17-beta-dehydrogenase 8
Uniport IdQ92506
GeneHSD17B8
Gene Id7923
Domainadh_short_C2
Pfam -  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00061 Fatty acid biosynthesis
1. Metabolism 1.3 Lipid metabolism hsa00140 Steroid hormone biosynthesis
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
1. Metabolism 1.0 Global and overview maps hsa01212 Fatty acid metabolism
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0008209 androgen metabolic process
Biological Process GO:0006703 estrogen biosynthetic process
Biological Process GO:0006633 fatty acid biosynthetic process
Biological Process GO:0046949 fatty-acyl-CoA biosynthetic process
Biological Process GO:0055114 oxidation-reduction process
Biological Process GO:0051290 protein heterotetramerization
molecular function GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity
molecular function GO:0004303 estradiol 17-beta-dehydrogenase activity
molecular function GO:0070404 NADH binding
molecular function GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
molecular function GO:0048038 quinone binding
molecular function GO:0047035 testosterone dehydrogenase (NAD+) activity
cellular component GO:0005740 mitochondrial envelope
cellular component GO:0005759 mitochondrial matrix
cellular component GO:0005886 plasma membrane
molecular function GO:0047025 3-oxoacyl-acyl-carrier-protein reductase (NADH) activity
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-75105 Fatty acyl-CoA biosynthesis
R-HSA-8978868 Fatty acid metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0027651 BXGD002009 Neoplasms Neoplasms
C0041296 BXGD002903 Tuberculosis Infections
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C2315100 BXGD017021 Pediatric failure to thrive Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Mental Disorders
C3887638 BXGD019906 Failure to thrive in infant Pathological Conditions, Signs and Symptoms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein