Showing entry for Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019382
Protein NamePhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
Uniport IdQ92835
GeneINPP5D
Gene Id3635
DomainExo_endo_phos; SH2
Pfam PF03372   PF00017  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.1 Carbohydrate metabolism hsa00562 Inositol phosphate metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04070 Phosphatidylinositol signaling system
5. Organismal Systems 5.1 Immune system hsa04662 B cell receptor signaling pathway
5. Organismal Systems 5.1 Immune system hsa04664 Fc epsilon RI signaling pathway
5. Organismal Systems 5.1 Immune system hsa04666 Fc gamma R-mediated phagocytosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006915 apoptotic process
Biological Process GO:0019221 cytokine-mediated signaling pathway
Biological Process GO:0008340 determination of adult lifespan
Biological Process GO:0016064 immunoglobulin mediated immune response
Biological Process GO:0043647 inositol phosphate metabolic process
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0050900 leukocyte migration
Biological Process GO:0030889 negative regulation of B cell proliferation
Biological Process GO:0045779 negative regulation of bone resorption
Biological Process GO:0050777 negative regulation of immune response
Biological Process GO:0032715 negative regulation of interleukin-6 production
Biological Process GO:0045656 negative regulation of monocyte differentiation
Biological Process GO:0045659 negative regulation of neutrophil differentiation
Biological Process GO:0045671 negative regulation of osteoclast differentiation
Biological Process GO:0009968 negative regulation of signal transduction
Biological Process GO:0006796 phosphate-containing compound metabolic process
Biological Process GO:0006661 phosphatidylinositol biosynthetic process
Biological Process GO:0046856 phosphatidylinositol dephosphorylation
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0045579 positive regulation of B cell differentiation
Biological Process GO:0045648 positive regulation of erythrocyte differentiation
Biological Process GO:0007165 signal transduction
Biological Process GO:0050852 T cell receptor signaling pathway
molecular function GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
molecular function GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity
molecular function GO:0004445 inositol-polyphosphate 5-phosphatase activity
molecular function GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
molecular function GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
molecular function GO:0017124 SH3 domain binding
cellular component GO:0005856 cytoskeleton
cellular component GO:0005829 cytosol
cellular component GO:0045121 membrane raft
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1280218 Adaptive Immune System
R-HSA-1430728 Metabolism
R-HSA-1483249 Inositol phosphate metabolism
R-HSA-1483255 PI Metabolism
R-HSA-1483257 Phospholipid metabolism
R-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-168256 Immune System
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol
R-HSA-202403 TCR signaling
R-HSA-202424 Downstream TCR signaling
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-210990 PECAM1 interactions
R-HSA-449147 Signaling by Interleukins
R-HSA-451927 Interleukin-2 family signaling
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-556833 Metabolism of lipids
R-HSA-912526 Interleukin receptor SHC signaling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0006840 BXGD000409 Candidiasis Infections
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0009090 BXGD000586 Cluttering Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009928 BXGD000637 Contrast Sensitivity
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0018133 BXGD001176 Graft-vs-Host Disease Immune System Diseases
C0020877 BXGD001471 Ileitis Digestive System Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023290 BXGD001631 Leishmaniasis, Visceral Infections
C0023418 BXGD001642 leukemia Neoplasms
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023465 BXGD001656 Acute monocytic leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024232 BXGD001751 Lymphatic Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027022 BXGD001962 Myeloproliferative disease Hemic and Lymphatic Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028860 BXGD002093 Oculocerebrorenal Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Nervous System Diseases
C0029401 BXGD002135 Osteitis Deformans Musculoskeletal Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0031099 BXGD002282 Periodontitis Stomatognathic Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0035126 BXGD002509 Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085669 BXGD003233 Acute leukemia Pathological Conditions, Signs and Symptoms; Neoplasms
C0149896 BXGD003382 Primary gout Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0156147 BXGD003838 Crohn's disease of large bowel Digestive System Diseases
C0200638 BXGD004043 Eosinophil count procedure
C0200641 BXGD004044 Blood basophil count (lab test)
C0232849 BXGD004565 Bladder pain Pathological Conditions, Signs and Symptoms
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0241910 BXGD005123 Autoimmune Chronic Hepatitis Digestive System Diseases; Immune System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0266929 BXGD005722 Chronic Periodontitis Stomatognathic Diseases
C0268398 BXGD005933 Familial lichen amyloidosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0276496 BXGD006426 Familial Alzheimer Disease (FAD) Nervous System Diseases; Mental Disorders
C0276680 BXGD006443 Infection by Candida albicans Infections
C0280321 BXGD006739 Squamous cell carcinoma of the hypopharynx
C0280449 BXGD006746 secondary acute myeloid leukemia Neoplasms
C0282488 BXGD006804 Interstitial Cystitis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0349639 BXGD007943 Juvenile Myelomonocytic Leukemia Neoplasms; Hemic and Lymphatic Diseases
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0494463 BXGD009029 Alzheimer Disease, Late Onset Nervous System Diseases; Mental Disorders
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0546126 BXGD009328 Acute Confusional Senile Dementia Nervous System Diseases; Mental Disorders
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0596887 BXGD009648 mathematical ability
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600040 BXGD009684 Chronic interstitial cystitis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0750900 BXGD010241 Alzheimer's Disease, Focal Onset Nervous System Diseases; Mental Disorders
C0750901 BXGD010242 Alzheimer Disease, Early Onset Nervous System Diseases; Mental Disorders
C0856825 BXGD011118 Acute GVH disease Immune System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1292769 BXGD012230 Precursor B-cell lymphoblastic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1292778 BXGD012237 Chronic myeloproliferative disorder Neoplasms; Hemic and Lymphatic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1318020 BXGD012391 Stromal keratitis Eye Diseases
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1527304 BXGD013266 Allergic Reaction Immune System Diseases
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1961099 BXGD016672 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1998028 BXGD016865 Photoreceptor degeneration Eye Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2363741 BXGD017100 HIV-1 infection
C2609253 BXGD017172 Macrovascular disease
C3160917 BXGD018499 Bladder pain syndrome
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3544347 BXGD019116 Intestinal fibrosis
C4521042 BXGD023055 Complete Trisomy 21 Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4721555 BXGD023755 Autoimmune hepatitis Digestive System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0018772 Pseudoephedrine 165.12
BXGC0030109 Ephedrine 165.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein