Showing entry for Far upstream element-binding protein 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019397
Protein NameFar upstream element-binding protein 2
Uniport IdQ92945
GeneKHSRP
Gene Id8570
DomainDUF1897; KH_1
Pfam PF09005   PF00013  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0061158 3'-UTR-mediated mRNA destabilization
Biological Process GO:0071345 cellular response to cytokine stimulus
Biological Process GO:0010586 miRNA metabolic process
Biological Process GO:0006402 mRNA catabolic process
Biological Process GO:0006397 mRNA processing
Biological Process GO:0051028 mRNA transport
Biological Process GO:0010989 negative regulation of low-density lipoprotein particle clearance
Biological Process GO:0045019 negative regulation of nitric oxide biosynthetic process
Biological Process GO:0061014 positive regulation of mRNA catabolic process
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0010468 regulation of gene expression
Biological Process GO:2000628 regulation of miRNA metabolic process
Biological Process GO:0043488 regulation of mRNA stability
Biological Process GO:0008380 RNA splicing
Biological Process GO:0000375 RNA splicing, via transesterification reactions
molecular function GO:0003677 DNA binding
molecular function GO:0035925 mRNA 3'-UTR AU-rich region binding
molecular function GO:0003729 mRNA binding
molecular function GO:0003723 RNA binding
cellular component GO:0005737 cytoplasm
cellular component GO:0010494 cytoplasmic stress granule
cellular component GO:0005829 cytosol
cellular component GO:0016020 membrane
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-380994 ATF4 activates genes in response to endoplasmic reticulum stress
R-HSA-381042 PERK regulates gene expression
R-HSA-381119 Unfolded Protein Response (UPR)
R-HSA-392499 Metabolism of proteins
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements
R-HSA-450604 KSRP (KHSRP) binds and destabilizes mRNA
R-HSA-450604 KSRP (KHSRP) binds and destabilizes mRNA
R-HSA-8953854 Metabolism of RNA
R-HSA-8953854 Metabolism of RNA
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0005587 BXGD000316 Depression, Bipolar Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007112 BXGD000429 Adenocarcinoma of prostate Neoplasms; Male Urogenital Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0007959 BXGD000507 Charcot-Marie-Tooth Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0008487 BXGD000545 Chordoma Neoplasms
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013473 BXGD000845 Eating Disorders Mental Disorders
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014378 BXGD000912 Enterovirus Infections Infections
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0016057 BXGD001042 Fibrosarcoma Neoplasms
C0017075 BXGD001089 Ganglioneuroma Neoplasms
C0017150 BXGD001095 Gastrinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0017658 BXGD001138 Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0019829 BXGD001350 Hodgkin Disease Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020445 BXGD001386 Hypercholesterolemia, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020474 BXGD001397 Hyperlipidemia, Familial Combined Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020615 BXGD001445 Hypoglycemia Nutritional and Metabolic Diseases
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023470 BXGD001659 Myeloid Leukemia Neoplasms
C0023492 BXGD001671 Leukemia, T-Cell Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0026847 BXGD001940 Spinal Muscular Atrophy Nervous System Diseases
C0026936 BXGD001950 Mycoplasma Infections Infections
C0027022 BXGD001962 Myeloproliferative disease Hemic and Lymphatic Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027809 BXGD002040 Neurilemmoma Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0027868 BXGD002053 Neuromuscular Diseases Nervous System Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030319 BXGD002208 Panic Disorder Mental Disorders
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0032227 BXGD002336 Pleural effusion disorder Respiratory Tract Diseases
C0035335 BXGD002540 Retinoblastoma Neoplasms; Eye Diseases
C0035455 BXGD002554 Rhinitis Infections; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0036349 BXGD002604 Paranoid Schizophrenia Mental Disorders
C0038013 BXGD002725 Ankylosing spondylitis Musculoskeletal Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0085669 BXGD003233 Acute leukemia Pathological Conditions, Signs and Symptoms; Neoplasms
C0086132 BXGD003264 Depressive Symptoms Behavior and Behavior Mechanisms
C0149521 BXGD003328 Pancreatitis, Chronic Digestive System Diseases
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0151825 BXGD003481 Bone pain Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206623 BXGD004189 Adenosquamous carcinoma Neoplasms
C0206663 BXGD004225 Neuroectodermal Tumor, Primitive Neoplasms
C0206718 BXGD004264 Ganglioneuroblastoma Neoplasms
C0234251 BXGD004645 Inflammatory pain Pathological Conditions, Signs and Symptoms
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0240066 BXGD005016 Iron deficiency Nutritional and Metabolic Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278595 BXGD006545 Adult Fibrosarcoma Neoplasms
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0280220 BXGD006722 stage, ovarian epithelial cancer
C0282513 BXGD006808 Primary Progressive Aphasia (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0339543 BXGD007267 Epiretinal Membrane Eye Diseases
C0341747 BXGD007421 Detrusor and sphincter dyssynergia
C0341858 BXGD007425 Endometriosis of uterus Female Urogenital Diseases and Pregnancy Complications
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0345967 BXGD007756 Malignant mesothelioma Neoplasms; Respiratory Tract Diseases
C0346396 BXGD007821 Retinoma Neoplasms
C0349566 BXGD007928 Squamous cell carcinoma of tongue Neoplasms; Stomatognathic Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376544 BXGD008001 Hematopoietic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0549493 BXGD009385 Alveolitis Skin and Connective Tissue Diseases; Respiratory Tract Diseases
C0555198 BXGD009432 Malignant Glioma Neoplasms
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0595989 BXGD009632 Carcinoma of larynx Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0685938 BXGD009829 Malignant neoplasm of gastrointestinal tract Digestive System Diseases; Neoplasms
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0745103 BXGD010114 Hyperlipoproteinemia Type IIa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0850666 BXGD010901 Infection caused by Helicobacter pylori Infections
C1266186 BXGD011992 Retinoblastoma, spontaneously regressed Neoplasms
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1275126 BXGD012062 TNF receptor-associated periodic fever syndrome (TRAPS) Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1334953 BXGD012746 Neuroblastic tumors Neoplasms
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1522378 BXGD013254 Leukemia, Large Granular Lymphocytic Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1568363 BXGD013422 Tendinosis Musculoskeletal Diseases; Wounds and Injuries
C1608408 BXGD013434 Malignant transformation
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1845050 BXGD014703 PIGMENTARY DISORDER, RETICULATE, WITH SYSTEMIC MANIFESTATIONS Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1868683 BXGD016526 B-CELL MALIGNANCY, LOW-GRADE
C2004493 BXGD016875 Leukemia, B-Cell Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2363741 BXGD017100 HIV-1 infection
C2607914 BXGD017148 Allergic rhinitis (disorder) Respiratory Tract Diseases; Immune System Diseases; Otorhinolaryngologic Diseases
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2945695 BXGD018187 Limb ischemia
C3489532 BXGD018934 Cone-Rod Dystrophy 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4529962 BXGD023178 Fatty Liver Disease
C4554344 BXGD023564 IgE-mediated food allergy Immune System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722099 BXGD023789 High grade glioma Neoplasms
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001767 (E)-Resveratrol 228.25
BXGC0051100 dihydroartemisinin 284.16
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein