Showing entry for Major prion protein


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019576
Protein NameMajor prion protein
Uniport IdQ95211
GenePRNP
Gene Id100008658
DomainPrion; Prion_bPrPp; Prion_octapep
Pfam PF00377   PF11587   PF03991  
OrganismOryctolagus cuniculus (Rabbit)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0032147 activation of protein kinase activity
Biological Process GO:0035584 calcium-mediated signaling using intracellular calcium source
Biological Process GO:1904646 cellular response to amyloid-beta
Biological Process GO:0071280 cellular response to copper ion
Biological Process GO:0035690 cellular response to drug
Biological Process GO:0007611 learning or memory
Biological Process GO:0090647 modulation of age-related behavioral decline
Biological Process GO:0046007 negative regulation of activated T cell proliferation
Biological Process GO:1902430 negative regulation of amyloid-beta formation
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0070885 negative regulation of calcineurin-NFAT signaling cascade
Biological Process GO:1902951 negative regulation of dendritic spine maintenance
Biological Process GO:0043433 negative regulation of DNA-binding transcription factor activity
Biological Process GO:0032689 negative regulation of interferon-gamma production
Biological Process GO:0032700 negative regulation of interleukin-17 production
Biological Process GO:0032703 negative regulation of interleukin-2 production
Biological Process GO:0001933 negative regulation of protein phosphorylation
Biological Process GO:0050860 negative regulation of T cell receptor signaling pathway
Biological Process GO:1990535 neuron projection maintenance
Biological Process GO:0043525 positive regulation of neuron apoptotic process
Biological Process GO:1903078 positive regulation of protein localization to plasma membrane
Biological Process GO:0090314 positive regulation of protein targeting to membrane
Biological Process GO:0061098 positive regulation of protein tyrosine kinase activity
Biological Process GO:0031648 protein destabilization
Biological Process GO:0051260 protein homooligomerization
Biological Process GO:1905664 regulation of calcium ion import across plasma membrane
Biological Process GO:1900449 regulation of glutamate receptor signaling pathway
Biological Process GO:1902938 regulation of intracellular calcium activated chloride channel activity
Biological Process GO:1901379 regulation of potassium ion transmembrane transport
Biological Process GO:0006979 response to oxidative stress
molecular function GO:0001540 amyloid-beta binding
molecular function GO:0019828 aspartic-type endopeptidase inhibitor activity
molecular function GO:0005507 copper ion binding
molecular function GO:1903135 cupric ion binding
molecular function GO:1903136 cuprous ion binding
molecular function GO:0005539 glycosaminoglycan binding
molecular function GO:0042802 identical protein binding
molecular function GO:0008017 microtubule binding
molecular function GO:0002020 protease binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0038023 signaling receptor activity
molecular function GO:0031802 type 5 metabotropic glutamate receptor binding
cellular component GO:0031225 anchored component of membrane
cellular component GO:0009986 cell surface
cellular component GO:0005829 cytosol
cellular component GO:0030425 dendrite
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005794 Golgi apparatus
cellular component GO:0016234 inclusion body
cellular component GO:0045121 membrane raft
cellular component GO:0031965 nuclear membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0043195 terminal bouton
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein