Showing entry for E3 ubiquitin-protein ligase RNF125


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019652
Protein NameE3 ubiquitin-protein ligase RNF125
Uniport IdQ96EQ8
GeneRNF125
Gene Id54941
Domainzf-C3HC4_2; zf-Di19; zf_C2HC_14
Pfam PF05605   PF18574  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04622 RIG-I-like receptor signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002250 adaptive immune response
Biological Process GO:0039536 negative regulation of RIG-I signaling pathway
Biological Process GO:0032480 negative regulation of type I interferon production
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process
molecular function GO:0002039 p53 binding
molecular function GO:0031624 ubiquitin conjugating enzyme binding
molecular function GO:0061630 ubiquitin protein ligase activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0000139 Golgi membrane
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex
Reactome
Pathway Id Pathway Name
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003578 BXGD000211 Apnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007789 BXGD000488 Cerebral Palsy Nervous System Diseases
C0014057 BXGD000880 Japanese Encephalitis Infections; Nervous System Diseases
C0017168 BXGD001101 Gastroesophageal reflux disease Digestive System Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020255 BXGD001369 Hydrocephalus Nervous System Diseases
C0020555 BXGD001431 Hypertrichosis Skin and Connective Tissue Diseases
C0020615 BXGD001445 Hypoglycemia Nutritional and Metabolic Diseases
C0022575 BXGD001555 Keratoconjunctivitis Sicca Eye Diseases
C0024421 BXGD001770 Macroglossia Stomatognathic Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0034735 BXGD002487 Raynaud Phenomenon Cardiovascular Diseases
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038362 BXGD002749 Stomatitis Stomatognathic Diseases
C0039070 BXGD002787 Syncope Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0153452 BXGD003647 Malignant neoplasm of gallbladder Digestive System Diseases; Neoplasms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0221355 BXGD004447 Macrocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0233844 BXGD004620 Clumsiness Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0235782 BXGD004769 Gallbladder Carcinoma Digestive System Diseases; Neoplasms
C0277828 BXGD006480 Late fontanel closure
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0332890 BXGD006909 Congenital hemihypertrophy Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0399526 BXGD008251 Class III malocclusion Stomatognathic Diseases
C0423113 BXGD008473 Telecanthus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0424230 BXGD008522 Motor retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0426421 BXGD008561 Wide nose
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0575081 BXGD009512 Gait abnormality Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1527336 BXGD013271 Sjogren's Syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C1531647 BXGD013301 Cerebral ventriculomegaly Nervous System Diseases
C1839783 BXGD014407 Large forehead
C1840077 BXGD014434 Anteverted nostril
C1840380 BXGD014460 Persistent cavum septum pellucidum
C1853487 BXGD015340 Thick eyebrow
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2748055 BXGD017583 Hypoinsulinaemia (disorder)
C2986703 BXGD018240 Overgrowth Syndrome Pathological Conditions, Signs and Symptoms
C3278923 BXGD018748 Dilated ventricles (finding)
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4015710 BXGD020218 TENORIO SYNDROME
C4525297 BXGD023131 Stage 0 Gallbladder Cancer AJCC v8
C4525300 BXGD023132 Stage IIA Gallbladder Cancer AJCC v8
C4525301 BXGD023133 Stage IIB Gallbladder Cancer AJCC v8
C4525302 BXGD023134 Stage III Gallbladder Cancer AJCC v8
C4525305 BXGD023135 Stage IV Gallbladder Cancer AJCC v8
C4551583 BXGD023361 Cerebral cortical atrophy
C4551915 BXGD023441 Gait Disturbance, CTCAE
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein