Showing entry for BRCA1-associated RING domain protein 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019956
Protein NameBRCA1-associated RING domain protein 1
Uniport IdQ99728
GeneBARD1
Gene Id580
DomainAnk; zf-RING_6
Pfam PF12796   PF14835  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.4 Replication and repair hsa03440 Homologous recombination
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007050 cell cycle arrest
Biological Process GO:0006974 cellular response to DNA damage stimulus
Biological Process GO:0000729 DNA double-strand break processing
Biological Process GO:0006260 DNA replication
Biological Process GO:0006303 double-strand break repair via nonhomologous end joining
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0031441 negative regulation of mRNA 3'-end processing
Biological Process GO:0046826 negative regulation of protein export from nucleus
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0045732 positive regulation of protein catabolic process
Biological Process GO:0016579 protein deubiquitination
Biological Process GO:0085020 protein K6-linked ubiquitination
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0042325 regulation of phosphorylation
Biological Process GO:1901796 regulation of signal transduction by p53 class mediator
Biological Process GO:0001894 tissue homeostasis
molecular function GO:0019900 kinase binding
molecular function GO:0046872 metal ion binding
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0003723 RNA binding
molecular function GO:0004842 ubiquitin-protein transferase activity
cellular component GO:0070531 BRCA1-A complex
cellular component GO:0031436 BRCA1-BARD1 complex
cellular component GO:0005737 cytoplasm
cellular component GO:0036464 cytoplasmic ribonucleoprotein granule
cellular component GO:0016607 nuclear speck
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0000151 ubiquitin ligase complex
Reactome
Pathway Id Pathway Name
R-HSA-1640170 Cell Cycle
R-HSA-212436 Generic Transcription Pathway
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-392499 Metabolism of proteins
R-HSA-5633007 Regulation of TP53 Activity
R-HSA-5685938 HDR through Single Strand Annealing (SSA)
R-HSA-5685942 HDR through Homologous Recombination (HRR)
R-HSA-5688426 Deubiquitination
R-HSA-5689603 UCH proteinases
R-HSA-5689901 Metalloprotease DUBs
R-HSA-5693532 DNA Double-Strand Break Repair
R-HSA-5693537 Resolution of D-Loop Structures
R-HSA-5693538 Homology Directed Repair
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-5693571 Nonhomologous End-Joining (NHEJ)
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange
R-HSA-5693606 DNA Double Strand Break Response
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-597592 Post-translational protein modification
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-69473 G2/M DNA damage checkpoint
R-HSA-69481 G2/M Checkpoints
R-HSA-69620 Cell Cycle Checkpoints
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-73894 DNA Repair
R-HSA-74160 Gene expression (Transcription)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003130 BXGD000183 Anoxia Pathological Conditions, Signs and Symptoms
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006625 BXGD000401 Cachexia Pathological Conditions, Signs and Symptoms
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0009405 BXGD000607 Hereditary Nonpolyposis Colorectal Neoplasms Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms; Nutritional and Metabolic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027672 BXGD002020 Neoplastic Syndromes, Hereditary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
C0027708 BXGD002025 Nephroblastoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0029925 BXGD002181 Ovarian Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0030297 BXGD002204 Pancreatic Neoplasm Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0032927 BXGD002381 Precancerous Conditions Neoplasms
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0153567 BXGD003665 Uterine Cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0153579 BXGD003668 Malignant neoplasm of fallopian tube Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206681 BXGD004236 Adenocarcinoma, Clear Cell Neoplasms
C0220650 BXGD004310 Metastatic malignant neoplasm to brain Pathological Conditions, Signs and Symptoms; Neoplasms; Nervous System Diseases
C0238122 BXGD004882 Fallopian Tube Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0280216 BXGD006719 stage, neuroblastoma Neoplasms
C0281267 BXGD006770 bilateral breast cancer Neoplasms; Skin and Connective Tissue Diseases
C0281842 BXGD006787 Abnormality of the fallopian tube
C0282160 BXGD006797 Aplasia Cutis Congenita Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0346153 BXGD007781 Breast Cancer, Familial Neoplasms; Skin and Connective Tissue Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0544886 BXGD009319 Somatic mutation
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598935 BXGD009674 Tumor Initiation Pathological Conditions, Signs and Symptoms; Neoplasms
C0677776 BXGD009728 Hereditary Breast and Ovarian Cancer Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C0948303 BXGD011526 Carcinoma of peritoneum
C1112155 BXGD011647 Hereditary non-polyposis colorectal cancer syndrome
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1257931 BXGD011815 Mammary Neoplasms, Human Neoplasms; Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1333600 BXGD012636 Hereditary Malignant Neoplasm Neoplasms
C1333990 BXGD012670 Hereditary Nonpolyposis Colorectal Cancer Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms; Nutritional and Metabolic Diseases
C1333991 BXGD012671 Hereditary Non-Polyposis Colon Cancer Type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
C1336076 BXGD012828 Sporadic Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1514428 BXGD013203 Primary peritoneal carcinoma Digestive System Diseases; Neoplasms
C1518693 BXGD013225 Clear cell adenocarcinoma of ovary Neoplasms
C1611743 BXGD013456 Familial (FPAH)
C1960398 BXGD016658 HER2-positive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2348819 BXGD017057 Triple-Negative Breast Cancer Finding
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2936783 BXGD018136 Colorectal cancer, hereditary nonpolyposis, type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms; Nutritional and Metabolic Diseases
C2938924 BXGD018167 Oestrogen receptor positive breast cancer
C3469522 BXGD018911 BREAST CANCER, SUSCEPTIBILITY TO
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3642346 BXGD019245 Luminal B Breast Carcinoma
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4704874 BXGD023682 Mammary Carcinoma, Human Neoplasms; Skin and Connective Tissue Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C4725671 BXGD023833 High-Risk Neuroblastoma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0003705 Chloride 35.45
BXGC0007028 beta-Thujaplicin 164.2
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein