Showing entry for Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019958
Protein NamePhosphatidylinositol 4-phosphate 5-kinase type-1 alpha
Uniport IdQ99755
GenePIP5K1A
Gene Id8394
DomainPIP5K
Pfam PF01504  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.1 Carbohydrate metabolism hsa00562 Inositol phosphate metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04070 Phosphatidylinositol signaling system
3. Environmental Information Processing 3.2 Signal transduction hsa04072 Phospholipase D signaling pathway
4. Cellular Processes 4.1 Transport and catabolism hsa04144 Endocytosis
5. Organismal Systems 5.1 Immune system hsa04666 Fc gamma R-mediated phagocytosis
4. Cellular Processes 4.5 Cell motility hsa04810 Regulation of actin cytoskeleton
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05135 Yersinia infection
6. Human Diseases 6.1 Cancers: Overview hsa05231 Choline metabolism in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0031532 actin cytoskeleton reorganization
Biological Process GO:0090630 activation of GTPase activity
Biological Process GO:0060326 cell chemotaxis
Biological Process GO:0016477 cell migration
Biological Process GO:0010761 fibroblast migration
Biological Process GO:0048041 focal adhesion assembly
Biological Process GO:0006650 glycerophospholipid metabolic process
Biological Process GO:0030216 keratinocyte differentiation
Biological Process GO:0006909 phagocytosis
Biological Process GO:0006661 phosphatidylinositol biosynthetic process
Biological Process GO:0008654 phospholipid biosynthetic process
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
Biological Process GO:0097178 ruffle assembly
Biological Process GO:0007165 signal transduction
molecular function GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity
molecular function GO:0005524 ATP binding
molecular function GO:0019900 kinase binding
cellular component GO:0005829 cytosol
cellular component GO:0005925 focal adhesion
cellular component GO:0030027 lamellipodium
cellular component GO:0016607 nuclear speck
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0032587 ruffle membrane
Reactome
Pathway Id Pathway Name
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1430728 Metabolism
R-HSA-1483255 PI Metabolism
R-HSA-1483257 Phospholipid metabolism
R-HSA-162582 Signal Transduction
R-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-199418 Negative regulation of the PI3K/AKT network
R-HSA-556833 Metabolism of lipids
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-9006925 Intracellular signaling by second messengers
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0936223 BXGD011477 Metastatic Prostate Carcinoma Neoplasms; Male Urogenital Diseases
C1282496 BXGD012147 Metastasis from malignant tumor of prostate
C1318485 BXGD012394 Liver regeneration disorder Digestive System Diseases
C4552000 BXGD023473 Episodic Kinesigenic Dyskinesia 1 Pathological Conditions, Signs and Symptoms; Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein