Showing entry for Endophilin-A1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019978
Protein NameEndophilin-A1
Uniport IdQ99962
GeneSH3GL2
Gene Id6456
DomainBAR; SH3_2
Pfam PF03114   PF07653  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04144 Endocytosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Biological Process GO:1990416 cellular response to brain-derived neurotrophic factor stimulus
Biological Process GO:0007417 central nervous system development
Biological Process GO:0097484 dendrite extension
Biological Process GO:0060988 lipid tube assembly
Biological Process GO:0097753 membrane bending
Biological Process GO:0061024 membrane organization
Biological Process GO:0097749 membrane tubulation
Biological Process GO:1905604 negative regulation of blood-brain barrier permeability
Biological Process GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0001933 negative regulation of protein phosphorylation
Biological Process GO:0031175 neuron projection development
Biological Process GO:1903527 positive regulation of membrane tubulation
Biological Process GO:2000369 regulation of clathrin-dependent endocytosis
Biological Process GO:0002090 regulation of receptor internalization
Biological Process GO:0007165 signal transduction
Biological Process GO:0016191 synaptic vesicle uncoating
Biological Process GO:0099050 vesicle scission
molecular function GO:0042802 identical protein binding
molecular function GO:0008289 lipid binding
molecular function GO:0008022 protein C-terminus binding
molecular function GO:0019901 protein kinase binding
cellular component GO:0097441 basal dendrite
cellular component GO:0030669 clathrin-coated endocytic vesicle membrane
cellular component GO:0005829 cytosol
cellular component GO:0005769 early endosome
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0000139 Golgi membrane
cellular component GO:0098686 hippocampal mossy fiber to CA3 synapse
cellular component GO:0043025 neuronal cell body
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0098684 photoreceptor ribbon synapse
cellular component GO:0005886 plasma membrane
cellular component GO:0099523 presynaptic cytosol
cellular component GO:0098685 Schaffer collateral - CA1 synapse
cellular component GO:0030672 synaptic vesicle membrane
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1266738 Developmental Biology
R-HSA-1280218 Adaptive Immune System
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-166520 Signaling by NTRKs
R-HSA-166520 Signaling by NTRKs
R-HSA-168256 Immune System
R-HSA-177504 Retrograde neurotrophin signalling
R-HSA-177504 Retrograde neurotrophin signalling
R-HSA-177929 Signaling by EGFR
R-HSA-182971 EGFR downregulation
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-199991 Membrane Trafficking
R-HSA-199992 trans-Golgi Network Vesicle Budding
R-HSA-2132295 MHC class II antigen presentation
R-HSA-373760 L1CAM interactions
R-HSA-373760 L1CAM interactions
R-HSA-422475 Axon guidance
R-HSA-422475 Axon guidance
R-HSA-432720 Lysosome Vesicle Biogenesis
R-HSA-432722 Golgi Associated Vesicle Biogenesis
R-HSA-437239 Recycling pathway of L1
R-HSA-437239 Recycling pathway of L1
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5663205 Infectious disease
R-HSA-6806834 Signaling by MET
R-HSA-6807004 Negative regulation of MET activity
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell
R-HSA-8876384 Listeria monocytogenes entry into host cells
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9675108 Nervous system development
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007138 BXGD000446 Carcinoma, Transitional Cell Neoplasms
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014556 BXGD000932 Epilepsy, Temporal Lobe Nervous System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270824 BXGD006113 Visual seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280324 BXGD006740 Laryngeal Squamous Cell Carcinoma Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0280856 BXGD006767 Squamous cell carcinoma of vulva Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0343641 BXGD007636 Human papilloma virus infection Infections
C0346210 BXGD007802 Vulval intraepithelial neoplasia Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0438696 BXGD008805 Suicidal Behavior and Behavior Mechanisms
C0595989 BXGD009632 Carcinoma of larynx Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C2145472 BXGD016931 Urothelial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2826323 BXGD017790 Refractory Cytopenia of Childhood
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein