Showing entry for Genome polyprotein


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019983
Protein NameGenome polyprotein
Uniport IdQ99IB8
Gene
Gene Id
Domain-
Pfam PF07652   PF01543   PF01542   PF01539   PF01560   PF01538   PF01006   PF01001   PF01506   PF08300   PF08301   PF12941   PF02907   PF00998  
OrganismHepatitis C virus genotype 2a (isolate JFH-1) (HCV)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0075512 clathrin-dependent endocytosis of virus by host cell
Biological Process GO:0039654 fusion of virus membrane with host endosome membrane
Biological Process GO:0052064 induction by symbiont of defense-related host reactive oxygen species production
Biological Process GO:0039520 induction by virus of host autophagy
Biological Process GO:0039614 induction by virus of host protein phosphorylation
Biological Process GO:0039645 modulation by virus of host G1/S transition checkpoint
Biological Process GO:1902902 negative regulation of autophagosome assembly
Biological Process GO:0010507 negative regulation of autophagy
Biological Process GO:1903147 negative regulation of autophagy of mitochondrion
Biological Process GO:0032715 negative regulation of interleukin-6 production
Biological Process GO:1903637 negative regulation of protein insertion into mitochondrial outer membrane
Biological Process GO:1903215 negative regulation of protein targeting to mitochondrion
Biological Process GO:0031397 negative regulation of protein ubiquitination
Biological Process GO:0034136 negative regulation of toll-like receptor 2 signaling pathway
Biological Process GO:0034144 negative regulation of toll-like receptor 4 signaling pathway
Biological Process GO:0034156 negative regulation of toll-like receptor 7 signaling pathway
Biological Process GO:0034164 negative regulation of toll-like receptor 9 signaling pathway
Biological Process GO:0039707 pore formation by virus in membrane of host cell
Biological Process GO:0032967 positive regulation of collagen biosynthetic process
Biological Process GO:0032914 positive regulation of transforming growth factor beta1 production
Biological Process GO:1901397 positive regulation of transforming growth factor beta2 activation
Biological Process GO:0051259 protein complex oligomerization
Biological Process GO:0002223 stimulatory C-type lectin receptor signaling pathway
Biological Process GO:0039545 suppression by virus of host MAVS activity
Biological Process GO:0039563 suppression by virus of host STAT1 activity
Biological Process GO:0039547 suppression by virus of host TRAF activity
Biological Process GO:0039653 suppression by virus of host transcription
Biological Process GO:0039502 suppression by virus of host type I interferon-mediated signaling pathway
Biological Process GO:0019087 transformation of host cell by virus
Biological Process GO:0039694 viral RNA genome replication
Biological Process GO:0019062 virion attachment to host cell
molecular function GO:0005524 ATP binding
molecular function GO:0004197 cysteine-type endopeptidase activity
molecular function GO:0042802 identical protein binding
molecular function GO:0005216 ion channel activity
molecular function GO:0003723 RNA binding
molecular function GO:0003968 RNA-directed 5'-3' RNA polymerase activity
molecular function GO:0003724 RNA helicase activity
molecular function GO:0004252 serine-type endopeptidase activity
molecular function GO:0017124 SH3 domain binding
molecular function GO:0005198 structural molecule activity
molecular function GO:0005160 transforming growth factor beta receptor binding
molecular function GO:0031625 ubiquitin protein ligase binding
molecular function GO:0008270 zinc ion binding
cellular component GO:0005576 extracellular region
cellular component GO:0030430 host cell cytoplasm
cellular component GO:0044165 host cell endoplasmic reticulum
cellular component GO:0044167 host cell endoplasmic reticulum membrane
cellular component GO:0044186 host cell lipid droplet
cellular component GO:0044191 host cell mitochondrial membrane
cellular component GO:0042025 host cell nucleus
cellular component GO:0044220 host cell perinuclear region of cytoplasm
cellular component GO:0020002 host cell plasma membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0044385 integral to membrane of host cell
cellular component GO:0019031 viral envelope
cellular component GO:0019013 viral nucleocapsid
cellular component GO:0055036 virion membrane
Reactome
Pathway Id Pathway Name
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-5621480 Dectin-2 family
R-HSA-5621481 C-type lectin receptors (CLRs)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0003705 Chloride 35.45
BXGC0003993 Uridine diphosphate 404.16
BXGC0030612 tetraethylene glycol 194.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein