Showing entry for Forkhead box protein P3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019985
Protein NameForkhead box protein P3
Uniport IdQ99JB6
GeneFoxp3
Gene Id20371
DomainForkhead; FOXP-CC
Pfam PF00250   PF16159  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0001782 B cell homeostasis
Biological Process GO:0002362 CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment
Biological Process GO:0001816 cytokine production
Biological Process GO:0002262 myeloid cell homeostasis
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0002677 negative regulation of chronic inflammatory response
Biological Process GO:0032792 negative regulation of CREB transcription factor activity
Biological Process GO:0042036 negative regulation of cytokine biosynthetic process
Biological Process GO:0050710 negative regulation of cytokine secretion
Biological Process GO:0043433 negative regulation of DNA-binding transcription factor activity
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0035067 negative regulation of histone acetylation
Biological Process GO:0031064 negative regulation of histone deacetylation
Biological Process GO:0050777 negative regulation of immune response
Biological Process GO:0050728 negative regulation of inflammatory response
Biological Process GO:0032689 negative regulation of interferon-gamma production
Biological Process GO:0032693 negative regulation of interleukin-10 production
Biological Process GO:0032700 negative regulation of interleukin-17 production
Biological Process GO:0032703 negative regulation of interleukin-2 production
Biological Process GO:0032713 negative regulation of interleukin-4 production
Biological Process GO:0032714 negative regulation of interleukin-5 production
Biological Process GO:0032715 negative regulation of interleukin-6 production
Biological Process GO:0048294 negative regulation of isotype switching to IgE isotypes
Biological Process GO:0050672 negative regulation of lymphocyte proliferation
Biological Process GO:0032088 negative regulation of NF-kappaB transcription factor activity
Biological Process GO:0002725 negative regulation of T cell cytokine production
Biological Process GO:0042130 negative regulation of T cell proliferation
Biological Process GO:2000320 negative regulation of T-helper 17 cell differentiation
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0032720 negative regulation of tumor necrosis factor production
Biological Process GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0035066 positive regulation of histone acetylation
Biological Process GO:0033092 positive regulation of immature T cell proliferation in thymus
Biological Process GO:0032753 positive regulation of interleukin-4 production
Biological Process GO:0002851 positive regulation of peripheral T cell tolerance induction
Biological Process GO:0045591 positive regulation of regulatory T cell differentiation
Biological Process GO:0002669 positive regulation of T cell anergy
Biological Process GO:0002666 positive regulation of T cell tolerance induction
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0032914 positive regulation of transforming growth factor beta1 production
Biological Process GO:0002637 regulation of immunoglobulin production
Biological Process GO:0048302 regulation of isotype switching to IgG isotypes
Biological Process GO:0002667 regulation of T cell anergy
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0009615 response to virus
Biological Process GO:0042110 T cell activation
Biological Process GO:0002456 T cell mediated immunity
Biological Process GO:0050852 T cell receptor signaling pathway
Biological Process GO:0002507 tolerance induction
Biological Process GO:0002513 tolerance induction to self antigen
molecular function GO:0003677 DNA binding
molecular function GO:0003700 DNA-binding transcription factor activity
molecular function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
molecular function GO:0035035 histone acetyltransferase binding
molecular function GO:0042826 histone deacetylase binding
molecular function GO:0042802 identical protein binding
molecular function GO:0046872 metal ion binding
molecular function GO:0051525 NFAT protein binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
molecular function GO:0043565 sequence-specific DNA binding
molecular function GO:1990837 sequence-specific double-stranded DNA binding
molecular function GO:0003714 transcription corepressor activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein