Showing entry for Toll-like receptor 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019990
Protein NameToll-like receptor 3
Uniport IdQ99MB1
GeneTlr3
Gene Id142980
DomainLRR_1; LRR_6; LRR_8; TIR; Tlr3_TMD
Pfam PF00560   PF13855   PF01582   PF17968  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0035690 cellular response to drug
Biological Process GO:0071360 cellular response to exogenous dsRNA
Biological Process GO:0035458 cellular response to interferon-beta
Biological Process GO:0071346 cellular response to interferon-gamma
Biological Process GO:0071260 cellular response to mechanical stimulus
Biological Process GO:0006952 defense response
Biological Process GO:0051607 defense response to virus
Biological Process GO:0097191 extrinsic apoptotic signaling pathway
Biological Process GO:0007252 I-kappaB phosphorylation
Biological Process GO:0006954 inflammatory response
Biological Process GO:0045087 innate immune response
Biological Process GO:0008584 male gonad development
Biological Process GO:0001774 microglial cell activation
Biological Process GO:0002756 MyD88-independent toll-like receptor signaling pathway
Biological Process GO:0097527 necroptotic signaling pathway
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0045080 positive regulation of chemokine biosynthetic process
Biological Process GO:0032722 positive regulation of chemokine production
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0050729 positive regulation of inflammatory response
Biological Process GO:0032727 positive regulation of interferon-alpha production
Biological Process GO:0032728 positive regulation of interferon-beta production
Biological Process GO:0032729 positive regulation of interferon-gamma production
Biological Process GO:0032735 positive regulation of interleukin-12 production
Biological Process GO:0032755 positive regulation of interleukin-6 production
Biological Process GO:0032757 positive regulation of interleukin-8 production
Biological Process GO:0046330 positive regulation of JNK cascade
Biological Process GO:0051092 positive regulation of NF-kappaB transcription factor activity
Biological Process GO:1901224 positive regulation of NIK/NF-kappaB signaling
Biological Process GO:0034123 positive regulation of toll-like receptor signaling pathway
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0032760 positive regulation of tumor necrosis factor production
Biological Process GO:0034346 positive regulation of type III interferon production
Biological Process GO:0032481 positive regulation of type I interferon production
Biological Process GO:0002730 regulation of dendritic cell cytokine production
Biological Process GO:0043331 response to dsRNA
Biological Process GO:0043330 response to exogenous dsRNA
Biological Process GO:0009615 response to virus
Biological Process GO:0034138 toll-like receptor 3 signaling pathway
Biological Process GO:0002224 toll-like receptor signaling pathway
molecular function GO:0003725 double-stranded RNA binding
molecular function GO:0042802 identical protein binding
molecular function GO:0038023 signaling receptor activity
molecular function GO:0004888 transmembrane signaling receptor activity
cellular component GO:0009986 cell surface
cellular component GO:0005737 cytoplasm
cellular component GO:0005769 early endosome
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0010008 endosome membrane
cellular component GO:0005887 integral component of plasma membrane
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0018397 beta-1,4-mannan 180.06
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein