Showing entry for Inosine triphosphate pyrophosphatase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020179
Protein NameInosine triphosphate pyrophosphatase
Uniport IdQ9BY32
GeneITPA
Gene Id3704
DomainHam1p_like
Pfam PF01725  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.4 Nucleotide metabolism hsa00230 Purine metabolism
1. Metabolism 1.11 Xenobiotics biodegradation and metabolism hsa00983 Drug metabolism - other enzymes
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0051276 chromosome organization
Biological Process GO:0009204 deoxyribonucleoside triphosphate catabolic process
Biological Process GO:0006193 ITP catabolic process
Biological Process GO:0009143 nucleoside triphosphate catabolic process
Biological Process GO:0006195 purine nucleotide catabolic process
molecular function GO:0035870 dITP diphosphatase activity
molecular function GO:0036218 dTTP diphosphatase activity
molecular function GO:0042802 identical protein binding
molecular function GO:0046872 metal ion binding
molecular function GO:0035529 NADH pyrophosphatase activity
molecular function GO:0047429 nucleoside-triphosphate diphosphatase activity
molecular function GO:0000166 nucleotide binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0016604 nuclear body
cellular component GO:0005654 nucleoplasm
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-15869 Metabolism of nucleotides
R-HSA-74259 Purine catabolism
R-HSA-8956319 Nucleobase catabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001824 BXGD000081 Agranulocytosis Hemic and Lymphatic Diseases
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0002878 BXGD000137 Anemia, Hemolytic Hemic and Lymphatic Diseases
C0002879 BXGD000138 Anemia, Hemolytic, Acquired Hemic and Lymphatic Diseases
C0002889 BXGD000146 Anemia, Microangiopathic Hemic and Lymphatic Diseases
C0003862 BXGD000230 Arthralgia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0004269 BXGD000265 Child attention deficit disorder Mental Disorders
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0007193 BXGD000451 Cardiomyopathy, Dilated Cardiovascular Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0017178 BXGD001102 Gastrointestinal Diseases Digestive System Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0020433 BXGD001379 Hyperbilirubinemia Pathological Conditions, Signs and Symptoms
C0021053 BXGD001476 Immune System Diseases Immune System Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0022107 BXGD001530 Irritable Mood Behavior and Behavior Mechanisms
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023530 BXGD001683 Leukopenia Hemic and Lymphatic Diseases
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024530 BXGD001783 Malaria Infections
C0025521 BXGD001876 Inborn Errors of Metabolism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027947 BXGD002061 Neutropenia Hemic and Lymphatic Diseases
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0041671 BXGD002930 Attention Deficit Disorder Mental Disorders
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0221021 BXGD004368 Microangiopathic hemolytic anemia Hemic and Lymphatic Diseases
C0221760 BXGD004474 brain cyst
C0232466 BXGD004543 Feeding difficulties
C0235081 BXGD004720 Tremor, Limb Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235946 BXGD004789 Cerebral atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0238644 BXGD004949 Anemia, severe Hemic and Lymphatic Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0241703 BXGD005109 High pitched voice
C0268124 BXGD005825 Adenosine deaminase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0275524 BXGD006376 Coinfection Infections
C0276289 BXGD006418 Zika Virus Infection Infections
C0280962 BXGD006768 Bone Marrow Suppression Hemic and Lymphatic Diseases
C0282687 BXGD006826 Hemorrhagic Fever, Ebola Infections
C0342800 BXGD007557 Inosine Triphosphatase Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0392171 BXGD008033 Influenza-like symptoms
C0392607 BXGD008057 Severe combined immunodeficiency due to adenosine deaminase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Hemic and Lymphatic Diseases
C0457506 BXGD008889 Reactive thrombocytosis Hemic and Lymphatic Diseases
C0524910 BXGD009248 Hepatitis C, Chronic Digestive System Diseases; Infections
C0543888 BXGD009300 Epileptic encephalopathy Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0746883 BXGD010153 Febrile Neutropenia Hemic and Lymphatic Diseases
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1336820 BXGD012864 Treatment-Induced Anemia Hemic and Lymphatic Diseases
C1608426 BXGD013436 Compensated cirrhosis
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1839630 BXGD014391 Severe muscular hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1858430 BXGD015792 Death in infancy
C1861453 BXGD016049 Pseudohyperkalemia Cardiff Nutritional and Metabolic Diseases
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2347126 BXGD017036 Microscopic Polyarteritis Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C2700617 BXGD017474 Irritation - emotion Behavior and Behavior Mechanisms
C3495559 BXGD018994 Juvenile arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3714757 BXGD019430 Juvenile rheumatoid arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4020732 BXGD020474 Mitochondrial abnormalities
C4021758 BXGD020761 Delayed CNS myelination
C4225256 BXGD022194 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 35
C4551584 BXGD023362 Brain atrophy Nervous System Diseases
C4552810 BXGD023525 Irritability, CTCAE
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0006198 Citric acid 192.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein