Showing entry for Transient receptor potential cation channel subfamily V member 4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020290
Protein NameTransient receptor potential cation channel subfamily V member 4
Uniport IdQ9EPK8
GeneTrpv4
Gene Id63873
DomainAnk; Ion_trans
Pfam PF00023   PF00520  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0031532 actin cytoskeleton reorganization
Biological Process GO:0007015 actin filament organization
Biological Process GO:0097497 blood vessel endothelial cell delamination
Biological Process GO:0070509 calcium ion import
Biological Process GO:0098703 calcium ion import across plasma membrane
Biological Process GO:1902656 calcium ion import into cytosol
Biological Process GO:0070588 calcium ion transmembrane transport
Biological Process GO:0006816 calcium ion transport
Biological Process GO:0060351 cartilage development involved in endochondral bone morphogenesis
Biological Process GO:0007043 cell-cell junction assembly
Biological Process GO:0006874 cellular calcium ion homeostasis
Biological Process GO:0071476 cellular hypotonic response
Biological Process GO:0071477 cellular hypotonic salinity response
Biological Process GO:0034605 cellular response to heat
Biological Process GO:0071470 cellular response to osmotic stress
Biological Process GO:0043622 cortical microtubule organization
Biological Process GO:0002024 diet induced thermogenesis
Biological Process GO:0097009 energy homeostasis
Biological Process GO:0042593 glucose homeostasis
Biological Process GO:0042538 hyperosmotic salinity response
Biological Process GO:0006971 hypotonic response
Biological Process GO:0046785 microtubule polymerization
Biological Process GO:0050891 multicellular organismal water homeostasis
Biological Process GO:1903444 negative regulation of brown fat cell differentiation
Biological Process GO:0010977 negative regulation of neuron projection development
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0007231 osmosensory signaling pathway
Biological Process GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production
Biological Process GO:2000340 positive regulation of chemokine (C-X-C motif) ligand 1 production
Biological Process GO:0007204 positive regulation of cytosolic calcium ion concentration
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0050729 positive regulation of inflammatory response
Biological Process GO:0032755 positive regulation of interleukin-6 production
Biological Process GO:0046330 positive regulation of JNK cascade
Biological Process GO:0010759 positive regulation of macrophage chemotaxis
Biological Process GO:0071642 positive regulation of macrophage inflammatory protein 1 alpha production
Biological Process GO:0031117 positive regulation of microtubule depolymerization
Biological Process GO:0071639 positive regulation of monocyte chemotactic protein-1 production
Biological Process GO:0043117 positive regulation of vascular permeability
Biological Process GO:1903715 regulation of aerobic respiration
Biological Process GO:0047484 regulation of response to osmotic stress
Biological Process GO:0032868 response to insulin
Biological Process GO:0006970 response to osmotic stress
Biological Process GO:0030103 vasopressin secretion
molecular function GO:0003779 actin binding
molecular function GO:0051015 actin filament binding
molecular function GO:0043014 alpha-tubulin binding
molecular function GO:0005524 ATP binding
molecular function GO:0048487 beta-tubulin binding
molecular function GO:0005262 calcium channel activity
molecular function GO:0005516 calmodulin binding
molecular function GO:0005261 cation channel activity
molecular function GO:0042802 identical protein binding
molecular function GO:0005216 ion channel activity
molecular function GO:0008289 lipid binding
molecular function GO:0046872 metal ion binding
molecular function GO:0008017 microtubule binding
molecular function GO:0005034 osmosensor activity
molecular function GO:0019901 protein kinase binding
molecular function GO:0005080 protein kinase C binding
molecular function GO:0042169 SH2 domain binding
molecular function GO:0015275 stretch-activated, cation-selective, calcium channel activity
cellular component GO:0005912 adherens junction
cellular component GO:0016324 apical plasma membrane
cellular component GO:0009986 cell surface
cellular component GO:0005929 cilium
cellular component GO:0030864 cortical actin cytoskeleton
cellular component GO:0005881 cytoplasmic microtubule
cellular component GO:0031410 cytoplasmic vesicle
cellular component GO:0030175 filopodium
cellular component GO:0005925 focal adhesion
cellular component GO:0030426 growth cone
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0030027 lamellipodium
cellular component GO:0005886 plasma membrane
cellular component GO:0032587 ruffle membrane
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0022307 Phorbol 12,13-Dibutyrate 504.27
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein