Showing entry for Toll-like receptor 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020291
Protein NameToll-like receptor 1
Uniport IdQ9EPQ1
GeneTlr1
Gene Id21897
DomainLRR_8; TIR
Pfam PF13855   PF01582  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007250 activation of NF-kappaB-inducing kinase activity
Biological Process GO:0001775 cell activation
Biological Process GO:0071221 cellular response to bacterial lipopeptide
Biological Process GO:0071727 cellular response to triacyl bacterial lipopeptide
Biological Process GO:0006952 defense response
Biological Process GO:0042495 detection of triacyl bacterial lipopeptide
Biological Process GO:0006954 inflammatory response
Biological Process GO:0045087 innate immune response
Biological Process GO:0042116 macrophage activation
Biological Process GO:0001774 microglial cell activation
Biological Process GO:0002755 MyD88-dependent toll-like receptor signaling pathway
Biological Process GO:0032755 positive regulation of interleukin-6 production
Biological Process GO:0032757 positive regulation of interleukin-8 production
Biological Process GO:0034137 positive regulation of toll-like receptor 2 signaling pathway
Biological Process GO:0042535 positive regulation of tumor necrosis factor biosynthetic process
Biological Process GO:0050707 regulation of cytokine secretion
Biological Process GO:0032493 response to bacterial lipoprotein
Biological Process GO:0034130 toll-like receptor 1 signaling pathway
Biological Process GO:0002224 toll-like receptor signaling pathway
molecular function GO:0042802 identical protein binding
molecular function GO:0071723 lipopeptide binding
molecular function GO:0050135 NAD(P)+ nucleosidase activity
molecular function GO:0061809 NAD+ nucleotidase, cyclic ADP-ribose generating
molecular function GO:0038023 signaling receptor activity
molecular function GO:0035663 Toll-like receptor 2 binding
molecular function GO:0004888 transmembrane signaling receptor activity
molecular function GO:0042497 triacyl lipopeptide binding
cellular component GO:0005794 Golgi apparatus
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0016020 membrane
cellular component GO:0045121 membrane raft
cellular component GO:0045335 phagocytic vesicle
cellular component GO:0030670 phagocytic vesicle membrane
cellular component GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006389 Rotenone 394.42
BXGC0031852 Cytochalasin D 507.26
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein