Showing entry for Serine/threonine-protein kinase/endoribonuclease IRE1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020301
Protein NameSerine/threonine-protein kinase/endoribonuclease IRE1
Uniport IdQ9EQY0
GeneErn1
Gene Id78943
DomainPkinase; Ribonuc_2-5A
Pfam PF00069   PF06479  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007257 activation of JUN kinase activity
Biological Process GO:0007050 cell cycle arrest
Biological Process GO:0071333 cellular response to glucose stimulus
Biological Process GO:0034620 cellular response to unfolded protein
Biological Process GO:0035924 cellular response to vascular endothelial growth factor stimulus
Biological Process GO:0030968 endoplasmic reticulum unfolded protein response
Biological Process GO:0001935 endothelial cell proliferation
Biological Process GO:1901142 insulin metabolic process
Biological Process GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Biological Process GO:0036498 IRE1-mediated unfolded protein response
Biological Process GO:0006379 mRNA cleavage
Biological Process GO:0098787 mRNA cleavage involved in mRNA processing
Biological Process GO:0070054 mRNA splicing, via endonucleolytic cleavage and ligation
Biological Process GO:0036289 peptidyl-serine autophosphorylation
Biological Process GO:1990579 peptidyl-serine trans-autophosphorylation
Biological Process GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response
Biological Process GO:0033120 positive regulation of RNA splicing
Biological Process GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0034976 response to endoplasmic reticulum stress
molecular function GO:0043531 ADP binding
molecular function GO:0005524 ATP binding
molecular function GO:0004519 endonuclease activity
molecular function GO:0004521 endoribonuclease activity
molecular function GO:0019899 enzyme binding
molecular function GO:0030544 Hsp70 protein binding
molecular function GO:0051879 Hsp90 protein binding
molecular function GO:0042802 identical protein binding
molecular function GO:0000287 magnesium ion binding
molecular function GO:0005161 platelet-derived growth factor receptor binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0004672 protein kinase activity
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:0051082 unfolded protein binding
cellular component GO:1990597 AIP1-IRE1 complex
cellular component GO:0005737 cytoplasm
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0030176 integral component of endoplasmic reticulum membrane
cellular component GO:1990630 IRE1-RACK1-PP2A complex
cellular component GO:1990604 IRE1-TRAF2-ASK1 complex
cellular component GO:0005739 mitochondrion
cellular component GO:0005637 nuclear inner membrane
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein