Showing entry for Ubiquitin-like modifier-activating enzyme 5


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020430
Protein NameUbiquitin-like modifier-activating enzyme 5
Uniport IdQ9GZZ9
GeneUBA5
Gene Id79876
DomainThiF
Pfam PF00899  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030218 erythrocyte differentiation
Biological Process GO:0030219 megakaryocyte differentiation
Biological Process GO:0050905 neuromuscular process
Biological Process GO:1990592 protein K69-linked ufmylation
Biological Process GO:0032446 protein modification by small protein conjugation
Biological Process GO:0071569 protein ufmylation
Biological Process GO:0033146 regulation of intracellular estrogen receptor signaling pathway
Biological Process GO:0034976 response to endoplasmic reticulum stress
Biological Process GO:0061709 reticulophagy
molecular function GO:0005524 ATP binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0071566 UFM1 activating enzyme activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0005794 Golgi apparatus
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-983169 Class I MHC mediated antigen processing & presentation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002418 BXGD000112 Amblyopia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004158 BXGD000261 Athetosis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0006157 BXGD000377 Breech Presentation Female Urogenital Diseases and Pregnancy Complications
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0008073 BXGD000518 Developmental Disabilities Mental Disorders
C0008370 BXGD000534 Cholestasis Digestive System Diseases
C0008489 BXGD000546 Chorea Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013384 BXGD000826 Dyskinetic syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014877 BXGD000967 Esotropia Eye Diseases; Nervous System Diseases
C0015310 BXGD000976 Exotropia Eye Diseases; Nervous System Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0017168 BXGD001101 Gastroesophageal reflux disease Digestive System Diseases
C0019193 BXGD001299 Hepatitis, Toxic Digestive System Diseases; Chemically-Induced Disorders
C0019572 BXGD001338 Hirsutism Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0020608 BXGD001443 Hypodontia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0021125 BXGD001483 Impulsive Behavior Behavior and Behavior Mechanisms
C0022107 BXGD001530 Irritable Mood Behavior and Behavior Mechanisms
C0022602 BXGD001564 Actinic keratosis Neoplasms; Skin and Connective Tissue Diseases
C0023221 BXGD001619 Leg Length Inequality Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026837 BXGD001937 Muscle Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027066 BXGD001966 Myoclonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0034152 BXGD002467 Henoch-Schoenlein Purpura Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0035304 BXGD002528 Retinal Degeneration Eye Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036857 BXGD002638 Severe intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0037769 BXGD002701 West Syndrome Nervous System Diseases
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0079352 BXGD003076 Congenital torticollis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0087012 BXGD003318 Ataxia, Spinocerebellar Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0151611 BXGD003447 Electroencephalogram abnormal Nervous System Diseases
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0231274 BXGD004490 Intolerant of heat
C0231686 BXGD004508 Gait, Unsteady Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0231687 BXGD004509 Spastic gait Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0232466 BXGD004543 Feeding difficulties
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0235659 BXGD004763 Reduced fetal movement Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0235946 BXGD004789 Cerebral atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0239174 BXGD004969 Late tooth eruption
C0239676 BXGD004989 High forehead
C0263401 BXGD005298 Cutis marmorata Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Skin and Connective Tissue Diseases; Cardiovascular Diseases; Wounds and Injuries
C0265529 BXGD005542 Plagiocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0267071 BXGD005730 Oropharyngeal Dysphagia Digestive System Diseases; Otorhinolaryngologic Diseases
C0269269 BXGD006058 Inversion of nipple (disorder) Skin and Connective Tissue Diseases
C0271385 BXGD006193 Horizontal Nystagmus Eye Diseases; Nervous System Diseases
C0311394 BXGD006884 Difficulty walking Pathological Conditions, Signs and Symptoms
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349588 BXGD007933 Short stature
C0401149 BXGD008273 Chronic constipation Pathological Conditions, Signs and Symptoms
C0423110 BXGD008471 Downward slant of palpebral fissure
C0423113 BXGD008473 Telecanthus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0423224 BXGD008475 Sunken eyes Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0424448 BXGD008529 Mask-like facies Nervous System Diseases
C0426848 BXGD008590 Sacral dimple Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0426886 BXGD008594 Tapering fingers (finding)
C0427190 BXGD008611 Ataxia, Truncal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0431478 BXGD008692 Posteriorly rotated ear
C0454641 BXGD008848 Expressive language delay
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0543888 BXGD009300 Epileptic encephalopathy Nervous System Diseases
C0549629 BXGD009393 Abnormal delivery
C0553723 BXGD009416 Squamous cell carcinoma of skin Neoplasms; Skin and Connective Tissue Diseases
C0557874 BXGD009444 Global developmental delay
C0683322 BXGD009782 Mental impairment
C0684276 BXGD009793 Hypsarrhythmia Nervous System Diseases
C0700379 BXGD009890 Total iron binding capacity function
C0740279 BXGD009973 Cerebellar atrophy
C0750937 BXGD010259 Ataxia, Appendicular Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751837 BXGD010604 Gait Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0752120 BXGD010668 Spinocerebellar Ataxia Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0752121 BXGD010669 Spinocerebellar Ataxia Type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0752122 BXGD010670 Spinocerebellar Ataxia Type 4 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0752123 BXGD010671 Spinocerebellar Ataxia Type 5 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0752124 BXGD010672 Spinocerebellar Ataxia Type 6 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0752125 BXGD010673 Spinocerebellar Ataxia Type 7 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0852413 BXGD010943 Abnormal muscle tone Nervous System Diseases
C0860207 BXGD011220 Drug-Induced Liver Disease Digestive System Diseases; Chemically-Induced Disorders
C0948163 BXGD011511 Leukoaraiosis Pathological Conditions, Signs and Symptoms
C1096063 BXGD011600 Drug Resistant Epilepsy Nervous System Diseases
C1262760 BXGD011886 Hepatitis, Drug-Induced Digestive System Diseases; Chemically-Induced Disorders
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1277241 BXGD012110 Delayed myelination Mental Disorders
C1283048 BXGD012160 Iron binding capacity total measurement
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1445953 BXGD013080 Poor eye contact Mental Disorders
C1456852 BXGD013126 Ventouse delivery (finding)
C1740801 BXGD013744 Exaggerated startle response
C1836038 BXGD014073 Poor head control Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1836830 BXGD014165 Developmental regression Mental Disorders
C1838391 BXGD014313 Limb hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1839767 BXGD014404 Tented upper lip vermilion
C1842581 BXGD014525 Abnormal corpus callosum morphology Pathological Conditions, Signs and Symptoms
C1845274 BXGD014736 Abnormal conjugate eye movement
C1846868 BXGD014846 Parkinsonism with favorable response to dopaminergic medication Nervous System Diseases
C1847514 BXGD014868 Postnatal microcephaly
C1849043 BXGD015000 Soft, doughy skin
C1853743 BXGD015358 Muscular hypotonia of the trunk Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1854882 BXGD015439 Absent speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1856408 BXGD015603 Infantile encephalopathy Nervous System Diseases
C1857704 BXGD015741 Abnormal myelination
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1859347 BXGD015879 Abnormal subcutaneous fat tissue distribution
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2315100 BXGD017021 Pediatric failure to thrive Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Mental Disorders
C2700617 BXGD017474 Irritation - emotion Behavior and Behavior Mechanisms
C2919142 BXGD017867 Short Stature, CTCAE
C2985280 BXGD018223 Blood Protein Measurement
C3553450 BXGD019175 Profound global developmental delay
C3658290 BXGD019256 Drug-Induced Acute Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3887638 BXGD019906 Failure to thrive in infant Pathological Conditions, Signs and Symptoms
C4021227 BXGD020587 Underdeveloped nasolabial fold
C4021758 BXGD020761 Delayed CNS myelination
C4022735 BXGD020971 Cerebral white matter atrophy Pathological Conditions, Signs and Symptoms
C4023687 BXGD021243 EEG with multifocal slow activity
C4025724 BXGD021758 Abnormality of the cerebral ventricles
C4025846 BXGD021826 Abnormality of vision
C4048268 BXGD021896 Cortical visual impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C4072908 BXGD022022 Induced vaginal delivery
C4277682 BXGD022376 Chemical and Drug Induced Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4279912 BXGD022378 Chemically-Induced Liver Toxicity Digestive System Diseases; Chemically-Induced Disorders
C4310699 BXGD022630 SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 24
C4310700 BXGD022631 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 44
C4317146 BXGD022730 Acid reflux
C4551563 BXGD023351 Microcephaly (physical finding)
C4552072 BXGD023482 X-linked infantile spasms Nervous System Diseases
C4552810 BXGD023525 Irritability, CTCAE
C4553743 BXGD023548 Spasticity, CTCAE
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
BXGC0024261 Adenosine Phosphate 347.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein