Showing entry for Myosin light chain kinase 2, skeletal/cardiac muscle


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020446
Protein NameMyosin light chain kinase 2, skeletal/cardiac muscle
Uniport IdQ9H1R3
GeneMYLK2
Gene Id85366
DomainPkinase
Pfam PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04020 Calcium signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04022 cGMP-PKG signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04270 Vascular smooth muscle contraction
3. Environmental Information Processing 3.2 Signal transduction hsa04371 Apelin signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04510 Focal adhesion
5. Organismal Systems 5.1 Immune system hsa04611 Platelet activation
4. Cellular Processes 4.5 Cell motility hsa04810 Regulation of actin cytoskeleton
5. Organismal Systems 5.2 Endocrine system hsa04921 Oxytocin signaling pathway
5. Organismal Systems 5.4 Digestive system hsa04971 Gastric acid secretion
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0060048 cardiac muscle contraction
Biological Process GO:0055008 cardiac muscle tissue morphogenesis
Biological Process GO:0007274 neuromuscular synaptic transmission
Biological Process GO:0018107 peptidyl-threonine phosphorylation
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0032971 regulation of muscle filament sliding
Biological Process GO:0035914 skeletal muscle cell differentiation
Biological Process GO:0014816 skeletal muscle satellite cell differentiation
Biological Process GO:0006941 striated muscle contraction
molecular function GO:0005524 ATP binding
molecular function GO:0005516 calmodulin binding
molecular function GO:0004683 calmodulin-dependent protein kinase activity
molecular function GO:0032027 myosin light chain binding
molecular function GO:0004687 myosin light chain kinase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005634 nucleus
cellular component GO:0030017 sarcomere
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002793 BXGD000130 Anaplasia Pathological Conditions, Signs and Symptoms; Neoplasms
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011071 BXGD000696 Sudden death Pathological Conditions, Signs and Symptoms
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0022104 BXGD001529 Irritable Bowel Syndrome Digestive System Diseases
C0023269 BXGD001627 leiomyosarcoma Neoplasms
C0032181 BXGD002332 Platelet Count measurement
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0205682 BXGD004105 Waist-Hip Ratio
C0205700 BXGD004111 Asymmetric Septal Hypertrophy Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0278607 BXGD006548 Adult Leiomyosarcoma Neoplasms
C0279986 BXGD006705 Childhood Leiomyosarcoma Neoplasms
C0340375 BXGD007326 Subaortic stenosis Cardiovascular Diseases
C0369183 BXGD007960 Erythrocyte Mean Corpuscular Hemoglobin Test
C0410158 BXGD008408 Muscle damage
C0428474 BXGD008631 Serum LDL cholesterol measurement
C0432306 BXGD008770 Ichthyosis Bullosa of Siemens Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0853897 BXGD010985 Diabetic Cardiomyopathies Endocrine System Diseases; Cardiovascular Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0949658 BXGD011582 Cardiomyopathy, Hypertrophic, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1261502 BXGD011856 Finding of Mean Corpuscular Hemoglobin
C1262211 BXGD011876 Diarrhoea predominant irritable bowel syndrome
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C3495498 BXGD018989 Cardiomyopathy, Familial Hypertrophic, 1 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4021768 BXGD020766 Abnormality of metabolism/homeostasis
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein