Showing entry for P2Y purinoceptor 12


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020448
Protein NameP2Y purinoceptor 12
Uniport IdQ9H244
GeneP2RY12
Gene Id64805
Domain7tm_1
Pfam PF00001  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04611 Platelet activation
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007202 activation of phospholipase C activity
Biological Process GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Biological Process GO:0070588 calcium ion transmembrane transport
Biological Process GO:0019722 calcium-mediated signaling
Biological Process GO:0035585 calcium-mediated signaling using extracellular calcium source
Biological Process GO:0030030 cell projection organization
Biological Process GO:0071318 cellular response to ATP
Biological Process GO:0021808 cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0007599 hemostasis
Biological Process GO:0030032 lamellipodium assembly
Biological Process GO:1904124 microglial cell migration
Biological Process GO:0045596 negative regulation of cell differentiation
Biological Process GO:0010700 negative regulation of norepinephrine secretion
Biological Process GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
Biological Process GO:0070527 platelet aggregation
Biological Process GO:0033630 positive regulation of cell adhesion mediated by integrin
Biological Process GO:0050921 positive regulation of chemotaxis
Biological Process GO:0033626 positive regulation of integrin activation by cell surface receptor linked signal transduction
Biological Process GO:0043270 positive regulation of ion transport
Biological Process GO:1904141 positive regulation of microglial cell migration
Biological Process GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
Biological Process GO:0051897 positive regulation of protein kinase B signaling
Biological Process GO:1900029 positive regulation of ruffle assembly
Biological Process GO:0071805 potassium ion transmembrane transport
Biological Process GO:0043491 protein kinase B signaling
Biological Process GO:0051924 regulation of calcium ion transport
Biological Process GO:0050920 regulation of chemotaxis
Biological Process GO:1904139 regulation of microglial cell migration
Biological Process GO:0048678 response to axon injury
Biological Process GO:0006930 substrate-dependent cell migration, cell extension
Biological Process GO:0150063 visual system development
molecular function GO:0001609 G protein-coupled adenosine receptor activity
molecular function GO:0001621 G protein-coupled ADP receptor activity
molecular function GO:0045028 G protein-coupled purinergic nucleotide receptor activity
molecular function GO:0005085 guanyl-nucleotide exchange factor activity
cellular component GO:0009925 basal plasma membrane
cellular component GO:0005901 caveola
cellular component GO:0044298 cell body membrane
cellular component GO:0031253 cell projection membrane
cellular component GO:0009986 cell surface
cellular component GO:0009897 external side of plasma membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0031224 intrinsic component of membrane
cellular component GO:0005739 mitochondrion
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-162582 Signal Transduction
R-HSA-372790 Signaling by GPCR
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-392170 ADP signalling through P2Y purinoceptor 12
R-HSA-392518 Signal amplification
R-HSA-417957 P2Y receptors
R-HSA-418038 Nucleotide-like (purinergic) receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-500792 GPCR ligand binding
R-HSA-76002 Platelet activation, signaling and aggregation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0002965 BXGD000162 Angina, Unstable Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0005779 BXGD000336 Blood Coagulation Disorders Hemic and Lymphatic Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007274 BXGD000456 Carotid Artery Thrombosis Nervous System Diseases; Cardiovascular Diseases
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0009443 BXGD000612 Common Cold Infections; Respiratory Tract Diseases
C0010051 BXGD000646 Coronary Aneurysm Cardiovascular Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010072 BXGD000649 Coronary Thrombosis Cardiovascular Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013491 BXGD000847 Ecchymosis Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014591 BXGD000938 Epistaxis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0016522 BXGD001067 Foramen Ovale, Patent Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0018553 BXGD001203 Hamartoma Syndrome, Multiple Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019080 BXGD001279 Hemorrhage Pathological Conditions, Signs and Symptoms
C0019087 BXGD001280 Hemorrhagic Disorders Hemic and Lymphatic Diseases
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020452 BXGD001389 Hyperemia Cardiovascular Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023211 BXGD001615 Left Bundle-Branch Block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0026691 BXGD001917 Mucocutaneous Lymph Node Syndrome Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028840 BXGD002089 Ocular Hypertension Eye Diseases
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029804 BXGD002171 Other specified hemorrhagic conditions Hemic and Lymphatic Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030201 BXGD002194 Pain, Postoperative Pathological Conditions, Signs and Symptoms
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0034065 BXGD002454 Pulmonary Embolism Respiratory Tract Diseases; Cardiovascular Diseases
C0034068 BXGD002457 Pulmonary Eosinophilia Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0035305 BXGD002529 Retinal Detachment Eye Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0040053 BXGD002839 Thrombosis Cardiovascular Diseases
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0042487 BXGD002986 Venous Thrombosis Cardiovascular Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0042974 BXGD003019 von Willebrand Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085096 BXGD003123 Peripheral Vascular Diseases Cardiovascular Diseases
C0087086 BXGD003320 Thrombus Cardiovascular Diseases
C0149782 BXGD003365 Squamous cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0150055 BXGD003401 Chronic pain Pathological Conditions, Signs and Symptoms
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0206142 BXGD004161 Eosinophilic leukemia Hemic and Lymphatic Diseases
C0234251 BXGD004645 Inflammatory pain Pathological Conditions, Signs and Symptoms
C0242380 BXGD005158 Libman-Sacks Disease Skin and Connective Tissue Diseases; Immune System Diseases
C0242488 BXGD005170 Acute Lung Injury Respiratory Tract Diseases
C0242994 BXGD005205 Hantavirus Infections Infections
C0243010 BXGD005209 Viral Encephalitis Infections; Nervous System Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0271160 BXGD006166 Cortical cataract Eye Diseases
C0333209 BXGD006934 Platelet thrombus Cardiovascular Diseases
C0340076 BXGD007302 Asthmatic pulmonary eosinophilia Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0340288 BXGD007316 Stable angina Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0340804 BXGD007367 Hereditary vascular fragility Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0340978 BXGD007381 May-Hegglin anomaly Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0342384 BXGD007470 Idiopathic hypogonadotropic hypogonadism Endocrine System Diseases
C0344724 BXGD007701 Ostium secundum atrial septal defect Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0346040 BXGD007769 Stage 0 Skin Melanoma Neoplasms; Skin and Connective Tissue Diseases
C0346421 BXGD007827 Chronic eosinophilic leukemia Neoplasms; Hemic and Lymphatic Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0423798 BXGD008510 Increased tendency to bruise Wounds and Injuries
C0521170 BXGD009131 Osteoporotic Fractures Wounds and Injuries
C0574785 BXGD009506 Lower Urinary Tract Symptoms Pathological Conditions, Signs and Symptoms
C0589368 BXGD009622 Postoperative myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0596240 BXGD009638 Cancer Pain Pathological Conditions, Signs and Symptoms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699949 BXGD009872 airway disease Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0740447 BXGD009998 Diabetic peripheral neuropathy Nervous System Diseases; Endocrine System Diseases
C0741923 BXGD010045 cardiac event
C0742343 BXGD010061 Acute Chest Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0751214 BXGD010353 Hyperalgesia, Thermal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751633 BXGD010529 Carotid Artery Plaque Nervous System Diseases; Cardiovascular Diseases
C0836924 BXGD010864 Thrombocytosis Hemic and Lymphatic Diseases
C0856169 BXGD011096 Endothelial dysfunction
C0878773 BXGD011391 Overactive Bladder Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0917996 BXGD011425 Cerebral Aneurysm Nervous System Diseases; Cardiovascular Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C0948089 BXGD011504 Acute Coronary Syndrome Cardiovascular Diseases
C1264039 BXGD011909 von Willebrand Disease, Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1276061 BXGD012101 Acute non-ST segment elevation myocardial infarction (disorder) Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1292778 BXGD012237 Chronic myeloproliferative disorder Neoplasms; Hemic and Lymphatic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332201 BXGD012502 Adult Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1536220 BXGD013341 ST segment elevation myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1536221 BXGD013342 Non ST segment elevation myocardial infarction
C1536222 BXGD013343 Non STEMI
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1561921 BXGD013366 Non-ST elevation (NSTEMI) myocardial infarction
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1704436 BXGD013564 Peripheral Arterial Diseases Cardiovascular Diseases
C1842937 BXGD014546 AURAL ATRESIA, CONGENITAL Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1844374 BXGD014626 Persistent bleeding after trauma
C1853278 BXGD015327 Bleeding Disorder Due To P2RY12 Defect Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1861172 BXGD016016 Venous Thromboembolism Cardiovascular Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1960870 BXGD016669 Transformed migraine Nervous System Diseases
C1963943 BXGD016706 Atherothrombosis
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2607914 BXGD017148 Allergic rhinitis (disorder) Respiratory Tract Diseases; Immune System Diseases; Otorhinolaryngologic Diseases
C2931689 BXGD018049 Dystrophia myotonica 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3160886 BXGD018488 Non ST segment elevation acute coronary syndrome
C3203672 BXGD018574 CYP2C19 polymorphism
C3275069 BXGD018658 Chronic Total Occlusion Vessel
C3472698 BXGD018927 Non-allergic rhinitis Infections; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C4021646 BXGD020717 Prolonged bleeding after surgery
C4025272 BXGD021615 Peripheral arterial stenosis
C4025282 BXGD021622 Impaired ADP-induced platelet aggregation
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4255010 BXGD022310 Non-ST Elevated Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C4290140 BXGD022508 recurrent myocardial infarction
C4324584 BXGD022773 Periprocedural myocardial infarction
C4520764 BXGD023038 Stage 0 Cutaneous Melanoma AJCC v6 and v7
C4699152 BXGD023634 ST-segment elevation myocardial infarction (STEMI)
C4700045 BXGD023640 Non-ST-segment elevation myocardial infarction (NSTEMI)
C4704753 BXGD023679 Urinary Bladder, Underactive Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000537 Acetylsalicylic acid 180.16
BXGC0001881 Chrysophanol 254.24
BXGC0002061 Aloeemodin 270.24
BXGC0007029 Emodin 270.24
BXGC0007749 Physcion 284.26
BXGC0008058 Emodinanthrone 256.25
BXGC0034783 Doxorubicin 543.17
BXGC0046599 Aloin 418.13
BXGC0053763 Frangulin B 402.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein