Showing entry for Egl nine homolog 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020488
Protein NameEgl nine homolog 3
Uniport IdQ9H6Z9
GeneEGLN3
Gene Id112399
Domain2OG-FeII_Oxy_3
Pfam PF13640  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04066 HIF-1 signaling pathway
6. Human Diseases 6.1 Cancers: Overview hsa05200 Pathways in cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05211 Renal cell carcinoma
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process GO:0006915 apoptotic process
Biological Process GO:0006974 cellular response to DNA damage stimulus
Biological Process GO:0071456 cellular response to hypoxia
Biological Process GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline
Biological Process GO:0018126 protein hydroxylation
Biological Process GO:0042127 regulation of cell population proliferation
Biological Process GO:0043523 regulation of neuron apoptotic process
Biological Process GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
Biological Process GO:0001666 response to hypoxia
molecular function GO:0016706 2-oxoglutarate-dependent dioxygenase activity
molecular function GO:0008198 ferrous iron binding
molecular function GO:0031418 L-ascorbic acid binding
molecular function GO:0031545 peptidyl-proline 4-dioxygenase activity
molecular function GO:0031543 peptidyl-proline dioxygenase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1234174 Cellular response to hypoxia
R-HSA-1234174 Cellular response to hypoxia
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-HSA-2262752 Cellular responses to stress
R-HSA-2262752 Cellular responses to stress
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-8953897 Cellular responses to external stimuli
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002351 BXGD000108 Altitude Sickness Respiratory Tract Diseases
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0003130 BXGD000183 Anoxia Pathological Conditions, Signs and Symptoms
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0013274 BXGD000809 Patent ductus arteriosus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0014772 BXGD000948 Red Blood Cell Count measurement
C0017638 BXGD001132 Glioma Neoplasms
C0017658 BXGD001138 Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0018810 BXGD001231 heart rate
C0018935 BXGD001252 Hematocrit procedure
C0019562 BXGD001336 Von Hippel-Lindau Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Cardiovascular Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024419 BXGD001769 Waldenstrom Macroglobulinemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0026470 BXGD001903 Monoclonal Gammopathy of Undetermined Significance Immune System Diseases; Hemic and Lymphatic Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0031511 BXGD002304 Pheochromocytoma Neoplasms
C0032461 BXGD002356 Polycythemia Hemic and Lymphatic Diseases
C0039730 BXGD002826 Thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0040420 BXGD002861 Tonometry
C0042345 BXGD002977 Varicosity Cardiovascular Diseases
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0155877 BXGD003830 Allergic asthma Respiratory Tract Diseases; Immune System Diseases
C0158266 BXGD003878 Intervertebral Disc Degeneration Musculoskeletal Diseases
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0235833 BXGD004775 Congenital diaphragmatic hernia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0266006 BXGD005603 Pili torti-deafness syndrome Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0272139 BXGD006309 Erythrocytosis due to low atmospheric pressure Hemic and Lymphatic Diseases
C0274294 BXGD006367 Chronic mountain sickness Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0374997 BXGD007967 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0423319 BXGD008479 Atrophic iris Eye Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0684328 BXGD009795 Reasoning
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0751435 BXGD010440 Hyperphenylalaninaemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0856742 BXGD011111 Post MI Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C1136084 BXGD011708 Plasma cell dyscrasia Immune System Diseases; Hemic and Lymphatic Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1318485 BXGD012394 Liver regeneration disorder Digestive System Diseases
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1519670 BXGD013241 Tumor Angiogenesis Pathological Conditions, Signs and Symptoms
C1527405 BXGD013290 Erythrocytosis Hemic and Lymphatic Diseases
C1611743 BXGD013456 Familial (FPAH)
C1658953 BXGD013486 tumor vasculature
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2609414 BXGD017182 Acute kidney injury Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2945695 BXGD018187 Limb ischemia
C3825253 BXGD019687 Cataract in old age
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4282128 BXGD022420 PATENT DUCTUS ARTERIOSUS 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4528257 BXGD023159 Corpuscular Hemoglobin Concentration Mean
C4551683 BXGD023389 Adrenal Gland Pheochromocytoma Neoplasms; Endocrine System Diseases
C4703473 BXGD023650 Atherosclerotic lesion Cardiovascular Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000764 L-Ascorbic acid 176.12
BXGC0002485 2-Oxopentanedioic acid 146.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein