Showing entry for Spondin-1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020529
Protein NameSpondin-1
Uniport IdQ9HCB6
GeneSPON1
Gene Id10418
DomainReeler; Spond_N; TSP_1
Pfam PF02014   PF06468   PF00090  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007155 cell adhesion
Biological Process GO:1902430 negative regulation of amyloid-beta formation
Biological Process GO:1902993 positive regulation of amyloid precursor protein catabolic process
Biological Process GO:0032092 positive regulation of protein binding
Biological Process GO:0010954 positive regulation of protein processing
molecular function GO:0005201 extracellular matrix structural constituent
molecular function GO:0050693 LBD domain binding
molecular function GO:0046872 metal ion binding
cellular component GO:0005788 endoplasmic reticulum lumen
cellular component GO:0031012 extracellular matrix
cellular component GO:0005615 extracellular space
Reactome
Pathway Id Pathway Name
R-HSA-1643685 Disease
R-HSA-3781865 Diseases of glycosylation
R-HSA-3906995 Diseases associated with O-glycosylation of proteins
R-HSA-392499 Metabolism of proteins
R-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173105 O-linked glycosylation
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins
R-HSA-5668914 Diseases of metabolism
R-HSA-597592 Post-translational protein modification
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0005890 BXGD000345 Body Height
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0017741 BXGD001149 Glucose tolerance test
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029423 BXGD002143 Cartilaginous exostosis Neoplasms; Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0201657 BXGD004051 C-reactive protein measurement
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0235946 BXGD004789 Cerebral atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0278512 BXGD006528 Metastatic osteosarcoma Neoplasms
C0337437 BXGD007158 Glucagon measurement
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0392885 BXGD008071 High density lipoprotein measurement
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0523979 BXGD009227 Vitamin D3 measurement
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0919758 BXGD011440 Vitamin D measurement
C1269955 BXGD012005 Tumor Cell Invasion
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1536220 BXGD013341 ST segment elevation myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2985280 BXGD018223 Blood Protein Measurement
C4551584 BXGD023362 Brain atrophy Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0018397 beta-1,4-mannan 180.06
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein