Showing entry for E3 ubiquitin-protein ligase SMURF1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020532
Protein NameE3 ubiquitin-protein ligase SMURF1
Uniport IdQ9HCE7
GeneSMURF1
Gene Id57154
DomainC2; HECT; WW
Pfam PF00168   PF00632   PF00397  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa04120 Ubiquitin mediated proteolysis
4. Cellular Processes 4.1 Transport and catabolism hsa04144 Endocytosis
3. Environmental Information Processing 3.2 Signal transduction hsa04340 Hedgehog signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04350 TGF-beta signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030509 BMP signaling pathway
Biological Process GO:0030154 cell differentiation
Biological Process GO:0007398 ectoderm development
Biological Process GO:0061736 engulfment of target by autophagosome
Biological Process GO:0030514 negative regulation of BMP signaling pathway
Biological Process GO:0030279 negative regulation of ossification
Biological Process GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
Biological Process GO:0061734 parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
Biological Process GO:1903861 positive regulation of dendrite extension
Biological Process GO:0045732 positive regulation of protein catabolic process
Biological Process GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0006611 protein export from nucleus
Biological Process GO:0034394 protein localization to cell surface
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0071211 protein targeting to vacuole involved in autophagy
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0032801 receptor catabolic process
Biological Process GO:0061753 substrate localization to autophagosome
Biological Process GO:0007179 transforming growth factor beta receptor signaling pathway
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process
Biological Process GO:0030579 ubiquitin-dependent SMAD protein catabolic process
Biological Process GO:0060071 Wnt signaling pathway, planar cell polarity pathway
molecular function GO:0048185 activin binding
molecular function GO:0070411 I-SMAD binding
molecular function GO:0005543 phospholipid binding
molecular function GO:0070412 R-SMAD binding
molecular function GO:0061630 ubiquitin protein ligase activity
molecular function GO:0004842 ubiquitin-protein transferase activity
cellular component GO:0030424 axon
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0043025 neuronal cell body
cellular component GO:0005654 nucleoplasm
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1280218 Adaptive Immune System
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-168256 Immune System
R-HSA-170834 Signaling by TGF-beta Receptor Complex
R-HSA-170834 Signaling by TGF-beta Receptor Complex
R-HSA-195721 Signaling by WNT
R-HSA-201451 Signaling by BMP
R-HSA-212436 Generic Transcription Pathway
R-HSA-212436 Generic Transcription Pathway
R-HSA-2173788 Downregulation of TGF-beta receptor signaling
R-HSA-2173789 TGF-beta receptor signaling activates SMADs
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-HSA-3858494 Beta-catenin independent WNT signaling
R-HSA-4086400 PCP/CE pathway
R-HSA-4608870 Asymmetric localization of PCP proteins
R-HSA-5358351 Signaling by Hedgehog
R-HSA-5358351 Signaling by Hedgehog
R-HSA-5632684 Hedgehog 'on' state
R-HSA-5632684 Hedgehog 'on' state
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-74160 Gene expression (Transcription)
R-HSA-8878159 Transcriptional regulation by RUNX3
R-HSA-8878166 Transcriptional regulation by RUNX2
R-HSA-8878166 Transcriptional regulation by RUNX2
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-8941858 Regulation of RUNX3 expression and activity
R-HSA-9006936 Signaling by TGFB family members
R-HSA-9006936 Signaling by TGFB family members
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-983169 Class I MHC mediated antigen processing & presentation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001787 BXGD000076 Osteoporosis, Age-Related Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0005940 BXGD000352 Bone Diseases Musculoskeletal Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0009171 BXGD000587 Cocaine Abuse Chemically-Induced Disorders; Mental Disorders
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011644 BXGD000744 Scleroderma Skin and Connective Tissue Diseases
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029401 BXGD002135 Osteitis Deformans Musculoskeletal Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029459 BXGD002159 Osteoporosis, Senile Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029925 BXGD002181 Ovarian Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0030297 BXGD002204 Pancreatic Neoplasm Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0038587 BXGD002773 Substance Withdrawal Syndrome Chemically-Induced Disorders; Mental Disorders
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0041327 BXGD002916 Tuberculosis, Pulmonary Infections; Respiratory Tract Diseases
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0086189 BXGD003268 Drug Withdrawal Symptoms Chemically-Induced Disorders; Mental Disorders
C0087169 BXGD003321 Withdrawal Symptoms Chemically-Induced Disorders; Mental Disorders
C0151650 BXGD003454 Renal fibrosis Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0153381 BXGD003626 Malignant neoplasm of mouth Neoplasms; Stomatognathic Diseases
C0153690 BXGD003684 Secondary malignant neoplasm of bone Pathological Conditions, Signs and Symptoms; Neoplasms; Musculoskeletal Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0236642 BXGD004815 Pick Disease of the Brain Nervous System Diseases; Mental Disorders
C0236736 BXGD004825 Cocaine-Related Disorders Chemically-Induced Disorders; Mental Disorders
C0238339 BXGD004914 Hereditary pancreatitis Digestive System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0338451 BXGD007176 Frontotemporal dementia Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0431128 BXGD008664 Papillary craniopharyngioma Neoplasms
C0494165 BXGD009022 Secondary malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0600427 BXGD009706 Cocaine Dependence Chemically-Induced Disorders; Mental Disorders
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1535939 BXGD013323 Pneumocystis jiroveci pneumonia Infections; Respiratory Tract Diseases
C1609538 BXGD013444 Latent Tuberculosis Infections
C1858556 BXGD015805 OVERLAP CONNECTIVE TISSUE DISEASE Eye Diseases; Skin and Connective Tissue Diseases; Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2973725 BXGD018205 Pulmonary arterial hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3278509 BXGD018742 Spinal fusion
C4076671 BXGD022077 Prostate cancer metastatic to bone
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein