Showing entry for Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020537
Protein NameDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
Uniport IdQ9HCR9
GenePDE11A
Gene Id50940
DomainGAF; PDEase_I
Pfam PF01590   PF00233  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.4 Nucleotide metabolism hsa00230 Purine metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04934 Cushing syndrome
6. Human Diseases 6.5 Substance dependence hsa05032 Morphine addiction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0008152 metabolic process
Biological Process GO:0043951 negative regulation of cAMP-mediated signaling
Biological Process GO:0010754 negative regulation of cGMP-mediated signaling
Biological Process GO:0007165 signal transduction
molecular function GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
molecular function GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
molecular function GO:0030553 cGMP binding
molecular function GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
molecular function GO:0004112 cyclic-nucleotide phosphodiesterase activity
molecular function GO:0046872 metal ion binding
cellular component GO:0005829 cytosol
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-162582 Signal Transduction
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-392154 Nitric oxide stimulates guanylate cyclase
R-HSA-418346 Platelet homeostasis
R-HSA-418457 cGMP effects
R-HSA-418555 G alpha (s) signalling events
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001430 BXGD000054 Adenoma Neoplasms
C0001624 BXGD000067 Adrenal Gland Neoplasms Neoplasms; Endocrine System Diseases
C0001627 BXGD000068 Congenital adrenal hyperplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005890 BXGD000345 Body Height
C0010481 BXGD000673 Cushing Syndrome Endocrine System Diseases
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0018810 BXGD001231 heart rate
C0020507 BXGD001413 Hyperplasia Pathological Conditions, Signs and Symptoms
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020619 BXGD001447 Hypogonadism Endocrine System Diseases
C0021364 BXGD001500 Male infertility Male Urogenital Diseases
C0022821 BXGD001590 Kyphosis deformity of spine Musculoskeletal Diseases
C0025267 BXGD001845 Multiple Endocrine Neoplasia Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Endocrine System Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027092 BXGD001971 Myopia Eye Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027662 BXGD002015 Multiple Endocrine Neoplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Endocrine System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029454 BXGD002155 Osteopetrosis Musculoskeletal Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030421 BXGD002218 Paraganglioma Neoplasms
C0031511 BXGD002304 Pheochromocytoma Neoplasms
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0039590 BXGD002822 Testicular Neoplasms Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0042781 BXGD003000 Visceral Myopathy Digestive System Diseases
C0085631 BXGD003214 Agitation Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0085633 BXGD003216 Mood swings Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0152459 BXGD003600 Linear atrophy Pathological Conditions, Signs and Symptoms
C0153594 BXGD003669 Malignant neoplasm of testis Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0205851 BXGD004132 Germ cell tumor Neoplasms
C0206667 BXGD004228 Adrenal Cortical Adenoma Neoplasms; Endocrine System Diseases
C0206686 BXGD004241 Adrenocortical carcinoma Neoplasms; Endocrine System Diseases
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0238198 BXGD004893 Gastrointestinal Stromal Tumors Digestive System Diseases; Neoplasms
C0239479 BXGD004982 Round face
C0266449 BXGD005670 Congenital anomaly of brain Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Nervous System Diseases
C0282160 BXGD006797 Aplasia Cutis Congenita Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0334294 BXGD007025 Multiple adenomatous polyps Neoplasms
C0342443 BXGD007481 Adrenal Cushing's syndrome Endocrine System Diseases
C0342494 BXGD007489 Adrenocortical hyperplasia Endocrine System Diseases
C0346402 BXGD007823 Malignant neoplasm of adrenal cortex Neoplasms; Endocrine System Diseases
C0349588 BXGD007933 Short stature
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0406810 BXGD008374 Carney Complex Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Cardiovascular Diseases
C0423757 BXGD008504 Thin skin
C0423798 BXGD008510 Increased tendency to bruise Wounds and Injuries
C0428883 BXGD008639 Diastolic blood pressure
C0489786 BXGD009018 Height
C0541794 BXGD009262 Skeletal muscle atrophy
C0855197 BXGD011079 Malignant Testicular Germ Cell Tumor Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C0871470 BXGD011316 Systolic Pressure
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1298180 BXGD012246 Single tumor
C1336708 BXGD012852 Testicular Germ Cell Tumor Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C1390474 BXGD012969 Increased susceptibility to fractures
C1611743 BXGD013456 Familial (FPAH)
C1621895 BXGD013466 Adrenal hyperplasia Pathological Conditions, Signs and Symptoms; Neoplasms; Endocrine System Diseases
C1847319 BXGD014858 PARAGANGLIOMA AND GASTRIC STROMAL SARCOMA Digestive System Diseases; Neoplasms
C1850573 BXGD015154 Slender build Pathological Conditions, Signs and Symptoms
C1857451 BXGD015702 Acth-Independent Macronodular Adrenal Hyperplasia Endocrine System Diseases
C1858592 BXGD015812 Carney Triad Digestive System Diseases; Neoplasms; Respiratory Tract Diseases
C1864851 BXGD016259 Pigmented Nodular Adrenocortical Disease, Primary, 2 Endocrine System Diseases
C1963060 BXGD016679 Agitation, CTCAE 3.0
C1968851 BXGD016741 Pigmented micronodular adrenocortical disease
C1968855 BXGD016742 Paradoxical increased cortisol secretion on dexamethasone suppression test
C2919142 BXGD017867 Short Stature, CTCAE
C3893645 BXGD020037 response to ACE inhibitor
C3899154 BXGD020074 familial testicular germ cell tumor Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C4025669 BXGD021720 Decreased circulating ACTH level
C4025760 BXGD021781 Primary hypercortisolism
C4304832 BXGD022585 Primary pigmented nodular adrenocortical disease
C4331029 BXGD022809 Primary Pigmented Nodular Adrenal Dysplasia
C4551560 BXGD023349 Truncal obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C4551683 BXGD023389 Adrenal Gland Pheochromocytoma Neoplasms; Endocrine System Diseases
C4552855 BXGD023528 Agitation, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001502 Caffeine 194.19
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein